4-Bromoindoline

Product Name: 4-Bromoindoline
CAS No.: 86626-38-2
Chemical Name: 4-Bromoindoline
Synonyms: 4-bromoindoline;4-BROMO-2,3-DIHYDRO-1H-INDOLE;4-bromoindoline hydrochloride;1H-Indole,4-broMo-2,3-dihydro-;4-Bromo-2,3-dihydro-1H-indoline;4-BroMo-2,3-dihydro-1H-indole 1HCl salt;4-BROMO-2,3-DIHYDRO-1H-INDOLE HYDROCHLORIDE;4-Bromoindoline 4-Bromo-2,3-dihydro-1H-indole in stock Factory
CBNumber: CB8424369
Molecular Formula: C8H8BrN
Formula Weight: 198.06
MOL File: 86626-38-2.mol

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4-Bromoindoline Property

Boiling point:: 278.8±29.0 °C(Predicted)
Density: 1.514±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
pka: 4.20±0.20(Predicted)
form: liquid
color: Brown to reddish brown
InChI: InChI=1S/C8H8BrN/c9-7-2-1-3-8-6(7)4-5-10-8/h1-3,10H,4-5H2
InChIKey: YCJCSDSXVHEBRU-UHFFFAOYSA-N
SMILES: N1C2=C(C(Br)=CC=C2)CC1

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

TRC

Product number: B693523
Product name: 4-Bromoindoline
Packaging: 250mg
Price: $70
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB52023
Product name: 4-Bromo-2,3-dihydro-1H-indole
Packaging: 250mg
Price: $85
Updated: 2021/12/16

AK Scientific

Product number: W8895
Product name: 4-Bromoindoline
Packaging: 250mg
Price: $91
Updated: 2021/12/16

AK Scientific

Product number: W8895
Product name: 4-Bromoindoline
Packaging: 1g
Price: $107
Updated: 2021/12/16

Apolloscientific

Product number: OR910522
Product name: 4-Bromoindoline
Purity: 97%
Packaging: 1g
Price: $130
Updated: 2021/12/16

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4-Bromoindoline Chemical Properties,Usage,Production

Chemical Properties

Pale-yellow to Yellow to Brown Liquid

Uses

4-Bromoindoline is a simple active pharmaceutical building block that can be used as a basic skeleton for the preparation of the migraine drug Sumatriptan.

Synthesis

52488-36-5

86626-38-2

Step 1. 4-Bromoindole (5.00 mL, 39.9 mmol) was dissolved in a solvent mixture of acetic acid (5.00 mL, 87.9 mmol) and methanol (25.0 mL, 617 mmol) and the reaction system was cooled to 0°C. Sodium cyanoborohydride (7.52 g, 0.120 mol) was slowly added under stirring, followed by a slow warming of the reaction mixture to room temperature over 1 hour. After completion of the reaction, the mixture was concentrated and neutralized with saturated aqueous sodium bicarbonate solution. Extraction was carried out using ether and ethyl acetate, the organic phases were combined and washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated to give 4.11 g (52% yield) of 4-bromo-2,3-dihydro-1H-indole.

References

[1] Journal of Medicinal Chemistry, 2014, vol. 57, # 6, p. 2462 - 2471
[2] Patent: US2007/265258, 2007, A1. Location in patent: Page/Page column 24
[3] Patent: WO2007/100880, 2007, A1. Location in patent: Page/Page column 81
[4] Journal of Medicinal Chemistry, 2011, vol. 54, # 1, p. 166 - 178
[5] Organic Letters, 2013, vol. 15, # 22, p. 5662 - 5665

4-Bromoindoline Preparation Products And Raw materials

Raw materials

Hexane Sodium sulfate Sodium chloride Indoline Silver sulfate Benzene Bromine Sulfuric acid

Preparation Products

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4-Bromoindoline Suppliers

China 115 Germany 1 India 1 United Kingdom 2 United States 14 Global 133

Carbott PharmTech Inc.

Tel: 0535-6385396
Fax: +86 (535) 638-9971
Email: info@carbottpharm.com
Country: China
ProdList: 957
Advantage: 56

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Email: syeu@accelachem.com
Country: China
ProdList: 11015
Advantage: 58

Tongchuang Pharma(Suzhou). Co., Ltd.

Tel: 0512-63263366 18912765016
Fax: 0512-6326 3366
Email: tongtf110@sina.com
Country: China
ProdList: 993
Advantage: 62

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

PharmaBlock Sciences (Nanjing),Inc.

Tel: 025-86918202 4000255188
Fax: 86-025-86918232
Email: sales@pharmablock.com
Country: China
ProdList: 5000
Advantage: 55

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

China DongFan Chemical Co.,LTD

Tel: 86-0571-85151182
Fax: 86-0571-85151182
Country: China
ProdList: 5691
Advantage: 66

Syntechem Co.,Ltd

Tel
Fax: E-Mail Inquiry
Email: info@syntechem.com
Country: China
ProdList: 12984
Advantage: 57

Shanghai Sunway Pharmaceutical Technology Co., Ltd

Tel: 18270980682
Fax: 021 51613951
Email: mlcheng@sunwaypharm.cn
Country: China
ProdList: 8669
Advantage: 57

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View Lastest Price from 4-Bromoindoline manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 4-Bromoindoline 86626-38-2
Price: US $3.00-9.00/KG
Min. Order: 0.1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2025-06-25

Chemwill Asia Co.,Ltd.

Product: 4-Bromoindoline 4-Bromo-2,3-dihydro-1H-indole in stock Factory 86626-38-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: TOP 3 Factory in China
Supply Ability: Top 3 production capacity Factory
Release date: 2019-04-03

Career Henan Chemical Co

Product: 4-BROMO-2,3-DIHYDRO-1H-INDOLE 86626-38-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10000KGS
Release date: 2020-01-02

86626-38-2, 4-BromoindolineRelated Search:

4-BROMOISATIN 4-BROMOOXINDOLE 4-Bromo-5-methyl-2,3-indolinedione 4-BROMO-7-METHYLISATIN 4-Bromoindoline 4-BROMO-5-CHLOROINDOLINE-2,3-DIONE 4,6-DIBROMO ISATIN 4-BROMO-2,3-DIHYDRO-INDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 4-bromo-1-(3-chloropropyl)-2,3-dihydro-1H-indole-2,3-dione N-BOC-4-BROMOISATIN 3-amino-4-bromo-1,3-dihydro-2H-indol-2-one 4-bromo-3-(ethylamino)-1,3-dihydro-2H-indol-2-one 4-bromo-3-[(2-furylmethyl)amino]-1,3-dihydro-2H-indol-2-one 4-bromo-3-(methylamino)-1,3-dihydro-2H-indol-2-one 4-bromo-1-(2-chloroprop-2-en-1-yl)-2,3-dihydro-1H-indole-2,3-dione 4-bromo-3-(propylamino)-1,3-dihydro-2H-indol-2-one (4-bromo-2,3-dioxo-2,3-dihydro-1H-indol-1-yl)acetic acid 2-[(4-bromo-2-oxo-2,3-dihydro-1H-indol-3-yl)amino]acetamide

4-bromoindoline hydrochloride

4-bromoindoline

4-BROMO-2,3-DIHYDRO-1H-INDOLE

4-BROMO-2,3-DIHYDRO-1H-INDOLE HYDROCHLORIDE

1H-Indole,4-broMo-2,3-dihydro-

4-BroMo-2,3-dihydro-1H-indole 1HCl salt

4-Bromoindoline 4-Bromo-2,3-dihydro-1H-indole in stock Factory

4-Bromo-2,3-dihydro-1H-indoline

86626-38-2