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Z-D-GLU(OTBU)-OH

Product Name
Z-D-GLU(OTBU)-OH
CAS No.
51644-83-8
Chemical Name
Z-D-GLU(OTBU)-OH
Synonyms
Z-D-Glu-OtBu;Z-D-GLU(TBU)-OH;Z-D-GLU(OTBU)-OH;Cbz-D-Glu(OtBu)-OH;Z-D-Glu(OtBu)-OH, 98.5%;Z-D-GLUTAMIC ACID(OTBU)-OH;Z-D-GLU(OTBU)-OH USP/EP/BP;Z-D-glutamic acid γ-tert-butyl ester;Z-D-GLUTAMIC ACID-GAMMA-T-BUTYL ESTER;Cbz-D-glutamic acid-gamma t-butyl ester
CBNumber
CB8426686
Molecular Formula
C17H23NO6
Formula Weight
337.37
MOL File
51644-83-8.mol
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Z-D-GLU(OTBU)-OH Property

Boiling point:
522.6±50.0 °C(Predicted)
Density 
1?+-.0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,2-8°C
solubility 
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form 
Solid
pka
3.80±0.10(Predicted)
color 
White to off-white
optical activity
Consistent with structure
CAS DataBase Reference
51644-83-8(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
G598248
Product name
Z-D-Glu(OtBu)-OH
Packaging
1g
Price
$75
Updated
2021/12/16
Chem-Impex
Product number
02169
Product name
Z-D-glutamicacidγ-tert-butylester,≥98%(HPLC)
Purity
≥98%(HPLC)
Packaging
1G
Price
$13.5
Updated
2021/12/16
Chem-Impex
Product number
02169
Product name
Z-D-glutamicacidγ-tert-butylester,≥98%(HPLC)
Purity
≥98%(HPLC)
Packaging
5G
Price
$34.94
Updated
2021/12/16
AK Scientific
Product number
J95459
Product name
Z-D-Glu(OtBu)-OH
Packaging
5g
Price
$40
Updated
2021/12/16
Activate Scientific
Product number
AS113889
Product name
Z-D-Glu(OtBu)-OH
Purity
97+%
Packaging
25g
Price
$95
Updated
2021/12/16
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Z-D-GLU(OTBU)-OH Chemical Properties,Usage,Production

Uses

Z-D-Glu(OtBu)-OH is a glutamic acid derivative[1].

Synthesis

501-53-1

45125-00-6

51644-83-8

General procedure for the synthesis of Z-D-tert-butylglutamic acid from benzyl chloroformate and D-glutamic acid-5-tert-butyl ester: (R)-2-amino-5-(tert-butoxy)-5-oxopentanoic acid (1.00 g, 4.92 mmol) was suspended in a solvent mixture of THF (18.45 mL) and water (6.15 mL) and was cooled to 0 °C under ice bath conditions. Benzyl chloroformate (0.773 mL, 5.41 mmol) was added slowly and dropwise to the cooled suspension, followed by stirring the reaction mixture for 2.5 hours at 0 °C. Upon completion of the reaction, the reaction mixture was diluted with 50 mL of ethyl acetate and acidified with aqueous 1 N hydrochloric acid to pH 3. The aqueous phase was extracted three times with ethyl acetate, and the organic phases were combined, dried with anhydrous sodium sulfate, filtered, and concentrated under reduced pressure to give the crude product as a clear oil. The crude product was purified by silica gel column chromatography with a gradient of eluent from 100% hexane to 100% ethyl acetate to afford the target product (R)-2-((benzyloxy)carbonyl)amino)-5-(tert-butoxy)-5-oxopentanoic acid as a colorless oil (1.41 g, 71% yield). The product was characterized by 1H NMR (400 MHz, chloroform-d), δ 7.44-7.29 (m, 5H), 5.53 (d, J = 7.5 Hz, 1H), 5.13 (s, 2H), 4.41 (d, J = 5.1 Hz, 1H), 2.56-2.30 (m, 2H), 2.21 (dd, J = 13.5, 6.5 Hz, 1H) , 2.06-1.88 (m, 2H), 1.45 (s, 9H).

References

[1] Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144. DOI:10.1080/10408398.2012.708368

Z-D-GLU(OTBU)-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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Z-D-GLU(OTBU)-OH Suppliers

China 99 Germany 3 India 4 Japan 3 United Kingdom 4 United States 12 Global 125
chemcube
Tel
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Fax
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Email
sales@chemcube.eu
Country
Germany
ProdList
4083
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34
ABCR GmbH & CO. KG
Tel
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Fax
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Email
info@abcr.de
Country
Germany
ProdList
6831
Advantage
75
IRIS Biotech GmbH
Tel
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Fax
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Country
Germany
ProdList
4426
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View Lastest Price from Z-D-GLU(OTBU)-OH manufacturers

Sichuan Jiaying Lai Technology Co.,LTD
Product
Cbz-D-Glu(OtBu)-OH 51644-83-8
Price
US $1.00/g
Min. Order
1g
Purity
98%
Supply Ability
100KG
Release date
2019-07-22

51644-83-8, Z-D-GLU(OTBU)-OHRelated Search:

Z-D-GLU-OH N-Cbz-D-glutamic acid alpha-benzyl ester Z-D-Glu(OtBu)-OSu N-ALPHA-CARBOBENZOXY-D-GLUTAMIC ACID ALPHA-T-BUTYL ESTER DICYCLOHEXYLAMMONIUM SALT Z-D-Glu(OSu)-Obzl Z-D-Glu-OMe Z-D-Gln-Onp Z-D-GLU(OBZL)-OH Z-D-GLN-OH Z-D-ARG-OH N-alpha-Cbz-D-2-4-diaminobutanoic acid Z-D-ASP(OTBU)-OH H2O N-Carbobenzyloxy-D-asparagine (2R,3S)-N-CARBOBENZYLOXY-2-AMINO-3-METHYLPENTANOIC ACID Z-D-GLU(OME)-OH (R)-2-N-CBZ-AMINO-PENTANE-1,5-DIOL D(-)-Glutamic acid AC-GLU(OTBU)-OH

  • Z-D-Glu(OtBu)-OH, 98.5%
  • (2R)-2-{[(benzyloxy)carbonyl]amino}-5-(tert-butoxy)-5-oxopentanoic acid
  • Cbz-D-glutamic acid-gamma t-butyl ester
  • Z-D-glutaMic acid-gaMMa-tert-butyl ester
  • N-Benzyloxycarbonyl-D-glutaMic-acid 5-tert-butyl ester, 98%
  • N-[(Phenylmethoxy)carbonyl]-D-glutamic acid 5-(1,1-dimethylethyl) ester
  • D-GlutaMic acid,N-[(phenylMethoxy)carbonyl]-, 5-(1,1-diMethylethyl) ester
  • N-ALPHA-BENZYLOXYCARBONYL-D-GLUTAMIC-ACID-GAMMA-T-BUTYL ESTER
  • N-ALPHA-BENZYLOXYCARBONYL-D-GLUTAMIC-ACID--T-BUTYL ESTER
  • N-ALPHA-BENZYLOXYCARBONYL-D-GLUTAMIC-ACID-GAMMA-TERT-BUTYL ESTER
  • N-ALPHA-CARBOBENZOXY-D-GLUTAMIC ACID GAMMA-T-BUTYL ESTER
  • N-ALPHA-CBZ-D-GLUTAMIC ACID GAMMA-T-BUTYL ESTER
  • Z-D-GLU(TBU)-OH
  • Z-D-GLU(OTBU)-OH
  • Z-D-GLUTAMIC ACID(OTBU)-OH
  • Z-D-GLUTAMIC ACID-GAMMA-T-BUTYL ESTER
  • (R)-2-(benzyloxycarbonylamino)-5-tert-butoxy-5-oxopentanoic acid
  • N-Cbz-D-glutamic acid 5-tert-butyl ester
  • Cbz-D-Glu(OtBu)-OH
  • Z-D-Glu-OtBu
  • Z-D-glutamic acid γ-tert-butyl ester99%
  • N-Benzyloxycarbonyl-D-glutamic-acid5-tert-butylester,98%
  • 5-[(2-methylpropan-2-yl)oxy]-5-oxo-2-(phenylmethoxycarbonylamino)pentanoicaci
  • Z-D-GLU(OTBU)-OH USP/EP/BP
  • Z-D-glutamic acid γ-tert-butyl ester
  • (2R)-5-[(2-methylpropan-2-yl)oxy]-5-oxo-2-(phenylmethoxycarbonylamino)pentanoic acid
  • 51644-83-8
  • Z-Amino Acids and Derivatives
  • Z-Amino acid series