(R)-2-N-CBZ-AMINO-PENTANE-1,5-DIOL
- Product Name
- (R)-2-N-CBZ-AMINO-PENTANE-1,5-DIOL
- CAS No.
- 478646-28-5
- Chemical Name
- (R)-2-N-CBZ-AMINO-PENTANE-1,5-DIOL
- Synonyms
- (R)-2-N-Cbz-aminopentane-1,5-diol;(R)-Benzyl 1,5-dihydroxypentan-2-ylcarbamate;REF DUPL: (R)-2-N-Cbz-amino-pentane-1,5-diol;benzyl (R)-(1,5-dihydroxypentan-2-yl)carbamate;REF DUPL: (S)-benzyl 1,5-dihydroxypentan-2-ylcarbamate;(R)-(4-Hydroxy-1-hydroxymethylbutyl)carbamic acid benzyl ester;Carbamic acid, N-[(1R)-4-hydroxy-1-(hydroxymethyl)butyl]-, phenylmethyl ester;Carbamic acid, [(1R)-4-hydroxy-1-(hydroxymethyl)butyl]-, phenylmethyl ester (9CI)
- CBNumber
- CB51119555
- Molecular Formula
- C13H19NO4
- Formula Weight
- 253.29
- MOL File
- 478646-28-5.mol
(R)-2-N-CBZ-AMINO-PENTANE-1,5-DIOL Property
- Boiling point:
- 485.2±45.0 °C(Predicted)
- Density
- 1.192±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 11.77±0.46(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C227133
- Product name
- (R)-2-N-CBZ-Aminopentane-1,5-diol
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- FC147611
- Product name
- (R)-2-N-Cbz-amino-pentane-1,5-diol
- Packaging
- 250mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FC147611
- Product name
- (R)-2-N-Cbz-amino-pentane-1,5-diol
- Packaging
- 500mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- 1206AL
- Product name
- (R)-2-N-Cbz-amino-pentane-1,5-diol
- Packaging
- 1g
- Price
- $189
- Updated
- 2021/12/16
- Product number
- FC147611
- Product name
- (R)-2-N-Cbz-amino-pentane-1,5-diol
- Packaging
- 1g
- Price
- $225
- Updated
- 2021/12/16
(R)-2-N-CBZ-AMINO-PENTANE-1,5-DIOL Chemical Properties,Usage,Production
Synthesis
67436-17-3
478646-28-5
General procedure: In a dry four-necked flask equipped with a dropping funnel and thermometer, 150 g of (S)-dimethyl 2-(((benzyloxy)carbonyl)amino)pentanediyl ester (η= 2) was added. After cooling the reaction system to 0-10 °C, 150 g of tetrahydrofuran was added to dissolve the feedstock. Subsequently, 29 g of sodium borohydride was slowly added and 72 g of anhydrous ethanol was added. The reaction was carried out at 10~15°C and terminated by dropwise addition of 90 g of acetic acid. The pH of the reaction solution was adjusted to 4~5 and extracted by adding 330 g of water and 350 g of ethyl acetate. The organic phase was separated, washed sequentially with sodium carbonate solution and saturated brine, dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated under reduced pressure (-0.1 MPa, temperature below 45 °C) to give a solid product. Beating with 102 g of n-heptane, filtration and drying gave 111.5 g of (R)-2-N-Cbz-aminopentane-1,5-diol (compound of formula IV) as a white solid. The yield was 90.8%, chemical purity 96.3% and optical purity 99.8%.
References
[1] Patent: CN103570601, 2016, B. Location in patent: Paragraph 0066; 0067
(R)-2-N-CBZ-AMINO-PENTANE-1,5-DIOL Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (R)-2-N-CBZ-AMINO-PENTANE-1,5-DIOL manufacturers
- Product
- (R)-2-N-CBZ-AMINO-PENTANE-1,5-DIOL 478646-28-5
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-10