ChemicalBook > CAS DataBase List > (R)-2-N-CBZ-AMINO-PENTANE-1,5-DIOL

(R)-2-N-CBZ-AMINO-PENTANE-1,5-DIOL

Product Name
(R)-2-N-CBZ-AMINO-PENTANE-1,5-DIOL
CAS No.
478646-28-5
Chemical Name
(R)-2-N-CBZ-AMINO-PENTANE-1,5-DIOL
Synonyms
(R)-2-N-Cbz-aminopentane-1,5-diol;(R)-Benzyl 1,5-dihydroxypentan-2-ylcarbamate;REF DUPL: (R)-2-N-Cbz-amino-pentane-1,5-diol;benzyl (R)-(1,5-dihydroxypentan-2-yl)carbamate;REF DUPL: (S)-benzyl 1,5-dihydroxypentan-2-ylcarbamate;(R)-(4-Hydroxy-1-hydroxymethylbutyl)carbamic acid benzyl ester;Carbamic acid, N-[(1R)-4-hydroxy-1-(hydroxymethyl)butyl]-, phenylmethyl ester;Carbamic acid, [(1R)-4-hydroxy-1-(hydroxymethyl)butyl]-, phenylmethyl ester (9CI)
CBNumber
CB51119555
Molecular Formula
C13H19NO4
Formula Weight
253.29
MOL File
478646-28-5.mol
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(R)-2-N-CBZ-AMINO-PENTANE-1,5-DIOL Property

Boiling point:
485.2±45.0 °C(Predicted)
Density 
1.192±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
11.77±0.46(Predicted)
Appearance
White to off-white Solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
C227133
Product name
(R)-2-N-CBZ-Aminopentane-1,5-diol
Packaging
50mg
Price
$45
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC147611
Product name
(R)-2-N-Cbz-amino-pentane-1,5-diol
Packaging
250mg
Price
$75
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC147611
Product name
(R)-2-N-Cbz-amino-pentane-1,5-diol
Packaging
500mg
Price
$130
Updated
2021/12/16
AK Scientific
Product number
1206AL
Product name
(R)-2-N-Cbz-amino-pentane-1,5-diol
Packaging
1g
Price
$189
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC147611
Product name
(R)-2-N-Cbz-amino-pentane-1,5-diol
Packaging
1g
Price
$225
Updated
2021/12/16
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(R)-2-N-CBZ-AMINO-PENTANE-1,5-DIOL Chemical Properties,Usage,Production

Synthesis

67436-17-3

478646-28-5

General procedure: In a dry four-necked flask equipped with a dropping funnel and thermometer, 150 g of (S)-dimethyl 2-(((benzyloxy)carbonyl)amino)pentanediyl ester (η= 2) was added. After cooling the reaction system to 0-10 °C, 150 g of tetrahydrofuran was added to dissolve the feedstock. Subsequently, 29 g of sodium borohydride was slowly added and 72 g of anhydrous ethanol was added. The reaction was carried out at 10~15°C and terminated by dropwise addition of 90 g of acetic acid. The pH of the reaction solution was adjusted to 4~5 and extracted by adding 330 g of water and 350 g of ethyl acetate. The organic phase was separated, washed sequentially with sodium carbonate solution and saturated brine, dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated under reduced pressure (-0.1 MPa, temperature below 45 °C) to give a solid product. Beating with 102 g of n-heptane, filtration and drying gave 111.5 g of (R)-2-N-Cbz-aminopentane-1,5-diol (compound of formula IV) as a white solid. The yield was 90.8%, chemical purity 96.3% and optical purity 99.8%.

References

[1] Patent: CN103570601, 2016, B. Location in patent: Paragraph 0066; 0067

(R)-2-N-CBZ-AMINO-PENTANE-1,5-DIOL Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from (R)-2-N-CBZ-AMINO-PENTANE-1,5-DIOL manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
(R)-2-N-CBZ-AMINO-PENTANE-1,5-DIOL 478646-28-5
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-10-10

478646-28-5, (R)-2-N-CBZ-AMINO-PENTANE-1,5-DIOL Related Search:

(R)-2-N-CBZ-AMINO-PENTANE-1,5-DIOL 2-N-CARBOBENZYLOXY-2-DEOXY-D-GLUCOSAMINE N-Cbz-D-glutamic acid alpha-benzyl ester Z-D-GLU-OH Benzyl formate Benzyl carbamate Z-D-GLA(OTBU)2-OH N-ALPHA-CARBOBENZOXY-D-GLUTAMIC ACID ALPHA-T-BUTYL ESTER DICYCLOHEXYLAMMONIUM SALT 2-(BENZYLOXYCARBONYLAMINO)-2-DEOXY-D-GALACTOSE Z-D-GLU(OTBU)-OH a-D-Glucopyranoside,methyl 4-O-[2-O-acetyl-6-methyl-3-O-(phenylmethyl)-a-L-idopyranuronosyl]-2-deoxy-2-[[(phenylmethoxy)carbonyl]amino]-3-O-(phenylmethyl)-,6-acetate Z-D-GLU(OBZL)-OH Z-D-Glu-OMe Z-D-GLU(OME)-OH N-(F13 CBZ) D-GLUTAMTIC ACID Z-D-GLU(OBZL)-OH DCHA LABOTEST-BB LT00455703 CBZ-NEURAMINIC ACID

  • (R)-Benzyl 1,5-dihydroxypentan-2-ylcarbamate
  • (R)-2-N-Cbz-aminopentane-1,5-diol
  • (R)-(4-Hydroxy-1-hydroxymethylbutyl)carbamic acid benzyl ester
  • REF DUPL: (R)-2-N-Cbz-amino-pentane-1,5-diol
  • REF DUPL: (S)-benzyl 1,5-dihydroxypentan-2-ylcarbamate
  • Carbamic acid, [(1R)-4-hydroxy-1-(hydroxymethyl)butyl]-, phenylmethyl ester (9CI)
  • Carbamic acid, N-[(1R)-4-hydroxy-1-(hydroxymethyl)butyl]-, phenylmethyl ester
  • benzyl (R)-(1,5-dihydroxypentan-2-yl)carbamate
  • 478646-28-5