ChemicalBook > CAS DataBase List > 1-(PHENYLSULFONYL)PYRROLE

1-(PHENYLSULFONYL)PYRROLE

Product Name: 1-(PHENYLSULFONYL)PYRROLE
CAS No.: 16851-82-4
Chemical Name: 1-(PHENYLSULFONYL)PYRROLE
Synonyms: NSC 102019;BUTTPARK 95\50-50;N-PHENYLSULFONYLPYRROLE;N-BENZENESULFONYLPYRROLE;N-Benzenesulphonylpyrrole;1-(PHENYLSULFONYL)PYRROLE;Phenyl 1-Pyrrolyl Sulfone;1-(PHENYLSULPHONYL)PYRROLE;1-(Phenylsulfonyl)pyrrole>1-(Phenylsulfonyl)pyrrole,97%
CBNumber: CB8429869
Molecular Formula: C10H9NO2S
Formula Weight: 207.25
MOL File: 16851-82-4.mol

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1-(PHENYLSULFONYL)PYRROLE Property

Melting point:: 88-91 °C (lit.)
Boiling point:: 368.9±25.0 °C(Predicted)
Density: 1.2784 (rough estimate)
refractive index: 1.5250 (estimate)
storage temp.: Sealed in dry,Room Temperature
solubility: soluble in Methanol
form: Crystals or Crystalline Powder
pka: -8.50±0.70(Predicted)
color: Beige to light brown
BRN: 1619427
InChI: InChI=1S/C10H9NO2S/c12-14(13,11-8-4-5-9-11)10-6-2-1-3-7-10/h1-9H
InChIKey: PPPXRIUHKCOOMU-UHFFFAOYSA-N
SMILES: N1(S(C2=CC=CC=C2)(=O)=O)C=CC=C1
CAS DataBase Reference: 16851-82-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-37/39
WGK Germany: 3
HS Code: 29350090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 438839
Product name: 1-(Phenylsulfonyl)pyrrole
Purity: 98%
Packaging: 5g
Price: $75.8
Updated: 2023/06/20

TCI Chemical

Product number: P2095
Product name: 1-(Phenylsulfonyl)pyrrole
Purity: >98.0%(GC)
Packaging: 1g
Price: $16
Updated: 2025/07/31

TCI Chemical

Product number: P2095
Product name: 1-(Phenylsulfonyl)pyrrole
Purity: >98.0%(GC)
Packaging: 5g
Price: $49
Updated: 2025/07/31

TRC

Product number: P338308
Product name: 1-(Phenylsulfonyl)pyrrole
Packaging: 100mg
Price: $60
Updated: 2021/12/16

AK Scientific

Product number: J56429
Product name: 1-(Phenylsulfonyl)pyrrole
Packaging: 1g
Price: $15
Updated: 2021/12/16

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1-(PHENYLSULFONYL)PYRROLE Chemical Properties,Usage,Production

Chemical Properties

beige to light brown crystals or cryst. powder

Uses

1-(Phenylsulfonyl)pyrrole (1-phenylsulfonyl-1H-pyrrole) may be used in the synthesis of 1-(phenylsulfonyl)pyrrole-2-boronic acid, via lithiation of 1-(phenylsulfonyl)-pyrrole. It may be used for the synthesis of 1-phenylsulfonyl-1H-pyrrole-3-sulfonyl chloride derivatives, which affords sulfonamide derivatives by reaction with nitrogen nucleophiles.

General Description

1-(Phenylsulfonyl)pyrrole is a heterocyclic building block. 1-(Phenylsulfonyl) group serves as N-blocking and directing group in various organic syntheses.

Synthesis

109-97-7

98-09-9

16851-82-4

A solution of benzenesulfonyl chloride (1.92 mL, 15.0 mmol) in toluene (15.0 mL) was slowly added dropwise to a mixed system of toluene (30.0 mL) containing pyrrole (0.69 mL, 10.0 mmol), tetrabutylammonium hydrogensulfate (0.34 g, 1.0 mmol), and a 50% aqueous sodium hydroxide solution (10.0 mL) over a period of 15 min. The reaction mixture was stirred at room temperature and the progress of the reaction was monitored by thin layer chromatography (TLC).After 3 h, TLC analysis indicated that the reaction was complete. Subsequently, the two phases of the reaction solution were separated and the organic phase was washed sequentially with water and saturated saline, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by fast column chromatography (silica gel as stationary phase and 30% dichloromethane/hexane as eluent) to afford 1.81 g (87% yield) of the target compound 1-phenylsulfonylpyrrole as a white solid. Melting point: 86-87°C; 1H NMR (300 MHz, CDCl3) δ 6.30 (m, 2H), 7.17 (m, 2H), 7.50 (m, 2H), 7.57 (m, 1H), 7.84 (m, 1H), 7.87 (m, 1H).

References

[1] Synthesis, 2004, # 12, p. 1951 - 1954
[2] Tetrahedron, 2006, vol. 62, # 8, p. 1699 - 1707
[3] Tetrahedron, 1998, vol. 54, # 46, p. 13915 - 13928
[4] Patent: WO2005/82343, 2005, A2. Location in patent: Page/Page column 111
[5] Canadian Journal of Chemistry, 1985, vol. 63, p. 896 - 902

1-(PHENYLSULFONYL)PYRROLE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1-(PHENYLSULFONYL)PYRROLE manufacturers

Career Henan Chemical Co

Product: 1-(PHENYLSULFONYL)PYRROLE 16851-82-4
Price: US $8.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10tons
Release date: 2018-12-25

16851-82-4, 1-(PHENYLSULFONYL)PYRROLERelated Search:

N-Tosyl-3-pyrrolecarboxylic acid 2-ACETYL-1-TOSYLPYRROLE 3-ACETYL-1-(P-TOLYLSULFONYL)PYRROLE 1-(PHENYLSULFONYL)INDOLE 2-ACETYL-1-(PHENYLSULFONYL)PYRROLE 1-[(4-METHYLPHENYL)SULFONYL]-1H-INDOLE-3-CARBALDEHYDE 1-(PHENYLSULFONYL)PYRROLE 3-ACETYL-1-(PHENYLSULFONYL)PYRROLE,3-ACETYL-1-(PHENYLSULFONYL)PYRROLE 99+% 1-Tosylpyrrole 1-[1-(PHENYLSULFONYL)-1H-PYRROL-3-YL]ETHAN-1-ONE OXIME 1-[(4-CHLOROPHENYL)SULFONYL]-1H-PYRROLE 1-(PHENYLSULFONYL)-1H-PYRROLE-2-CARBALDEHYDE 3-(1-[(4-METHYLPHENYL)SULFONYL]-1H-INDOL-3-YL)ACRYLIC ACID BOC-TRP(MTS)-OH DCHA 1-(PHENYLSULFONYL)-2-PYRROLECARBONITRILE 1-(PHENYLSULFONYL)PYRROLE-2-BORONIC ACID 1-(Phenylsulfonyl)pyrrole-3-sulfonyl chloride 1-[(2-NITROPHENYL)SULFONYL]-1H-PYRROLE-2-CARBALDEHYDE

BUTTPARK 95\50-50

1-(PHENYLSULFONYL)PYRROLE

1-(PHENYLSULPHONYL)PYRROLE

1-(PHENYLSULFONYL)-1H-PYRROLE

1-(phenylsulphonyl)-1H-pyrrole

1-(BENZENESULFONYL)PYRROLE, 97%

N-BENZENESULFONYLPYRROLE

N-Benzenesulphonylpyrrole

1-(PHENYLSULFONYL)PYRROLE 97%

N-PHENYLSULFONYLPYRROLE

1-(Phenylsulfonyl)pyrrole,97%

1-(benzenesulfonyl)-1H-pyrrole

NSC 102019

1-(Phenylsulfonyl)pyrrole&gt

1H-Pyrrole, 1-(phenylsulfonyl)-

Phenyl 1-Pyrrolyl Sulfone

16851-82-4

16852-82-4

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