Mode of action
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Fusidine

Mode of action
Product Name
Fusidine
CAS No.
6990-06-3
Chemical Name
Fusidine
Synonyms
FUSIDIC ACID;Fusidinic acid;(Z)-2-((3R,4S,5S,8S,9S,10S,11R,13R,14S,16S)-16-Acetoxy-3,11-dihydroxy-4,8,10,14-tetramethyldodecahydro-1H-cyclopenta[a]phenanthren-17(2H,10H,14H)-ylidene)-6-methylhept-5-enoic acid;Fusidic acid CRS;29-NordaMMara-17(20),24-dien-21-oicacid, 16-(acetyloxy)-3,11-dihydroxy-, (3a,4a,8a,9b,11a,13a,14b,16b,17Z)-;(3ALPHA,4ALPHA,8ALPHA,9BETA,11ALPHA,13ALPHA,14BETA,16BETA,17Z)-16-(ACETYLOXY)-3,11-DIHYDROXY-29-NORDAMMARA-17(20),24-DIEN-21-OIC ACID;sq16603;ramycin;Fuzidin;Flucidin
CBNumber
CB8431174
Molecular Formula
C31H48O6
Formula Weight
516.72
MOL File
6990-06-3.mol
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Fusidine Property

Melting point:
190-192°C
Boiling point:
521.49°C (rough estimate)
alpha 
D20 -9° (chloroform)
Density 
1.0389 (rough estimate)
vapor pressure 
0-0Pa at 25℃
refractive index 
1.4890 (estimate)
storage temp. 
Sealed in dry,2-8°C
solubility 
Practically insoluble in water, freely soluble in ethanol (96 per cent)
pka
pK: 5.35 in water
form 
Solid
color 
White to Off-White
optical activity
-920 (c 1, CHCl3)
Water Solubility 
2.376-525000μg/L at 25℃
λmax
204nm(H2O)(lit.)
Merck 
14,4317
Stability:
Hygroscopic
LogP
2.68-6.75 at 20℃
CAS DataBase Reference
6990-06-3(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
36
WGK Germany 
3
RTECS 
RC1350000
HS Code 
29419000
Toxicity
LD50 in mice (g/kg): 1.2 s.c.; 1.5 orally (Godtfredsen)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
Y0001411
Product name
Fusidic acid
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
y0001411
Price
$220
Updated
2024/03/01
Sigma-Aldrich
Product number
Y0001394
Product name
Fusidic acid for peak identification
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
y0001394
Price
$153
Updated
2024/03/01
Sigma-Aldrich
Product number
PHR2810
Product name
Fusidic acid
Purity
certified reference material, pharmaceutical secondary standard
Packaging
50MG
Price
$344
Updated
2024/03/01
TCI Chemical
Product number
F1007
Product name
Fusidic Acid
Purity
>97.0%(HPLC)(T)
Packaging
1g
Price
$230
Updated
2024/03/01
TCI Chemical
Product number
F1007
Product name
Fusidic Acid
Purity
>97.0%(HPLC)(T)
Packaging
5g
Price
$809
Updated
2024/03/01
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Fusidine Chemical Properties,Usage,Production

Mode of action

Fusidic acid forms a stable complex with an elongation factor (EF-G) involved in translocation and with guanosine triphosphate (GTP), which provides energy for the translocation process. One round of translocation occurs, with hydrolysis of GTP, but the fusidic acid–EF-G–GDP complex cannot dissociate from the ribosome, thereby blocking further chain elongation and leaving peptidyl-tRNA in the P site.
Although protein synthesis in Gram-negative bacilli–and, indeed, mammalian cells–is susceptible to fusidic acid, the antibiotic penetrates poorly into these cells and the spectrum of action is virtually restricted to Gram-positive bacteria, notably staphylococci.

Description

Fusidic acid was found in the culture broth of a fungus imperfectus, Fusidium coccineum, by Leo in 1962. It has a steroid struc ture but shows no hormonal activity.

Chemical Properties

White Solid

Uses

antibacterial

Uses

Fusidic acid is a bacteriostatic antibiotic. Fusidic Acid suppresses nitric oxide lysis of pancreatic islet cells. Inhibits protein synthesis in prokaryotes by inhibiting the ribosome-dependent activity of G factor and translocation of peptidyl-tRNA. Dyes and metabolites.

Definition

ChEBI: A steroid antibiotic that is isolated from the fermentation broth of Fusidium coccineum.

brand name

Fucidine (Bristol-Myers Squibb).

Hazard

Moderately toxic inhibitor of translocation during protein synthesis.

Biological Activity

Fusidic acid shows very strong activity against Staphy lococcus aureus and weak activity against other gram-positive bacteria and gram-negative cocci and Mycobacterium.

Biochem/physiol Actions

Fusidic acid is a tetracyclic triterpenoid with antibiotic activity against Gram-positive bacteria. It is derived from Fusidium coccineum. It shows its activity against anaerobes, corynebacterial, Nocardia, and Neisseria species. Fusidic acid exhibits therapeutic effects against Staphylococcal infections, skin infections.

Fusidine Preparation Products And Raw materials

Raw materials

Preparation Products

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Fusidine Suppliers

Wuhan DKY Technology Co.,Ltd.
Tel
27-81302488 18007166089
Fax
027-81302088
Email
info@dkybpc.com
Country
China
ProdList
2024
Advantage
58
Taizhou Hoyoo Chemical Co.,Ltd
Tel
0576-0576-88666163 15057600339
Fax
0576-88666163
Email
hoyoochem@yahoo.com
Country
China
ProdList
111
Advantage
58
xi'an renyang Biotechnology Co., Ltd.
Tel
13299086402
Email
renyangbiotech@163.com
Country
China
ProdList
80
Advantage
58
Hubei Chanmol Biotech Co., Ltd.
Tel
0711-3812399 18062309155
Email
156941107@qq.com
Country
China
ProdList
3000
Advantage
58
Shanghai Minkai Biological Technology Co., Ltd
Tel
021-021-52919136 17315815539
Email
2804155403@qq.com
Country
China
ProdList
205
Advantage
58
HUBEI MICRO PHARMACEUTICAL
Tel
18627055345
Email
info@micropharm.cn
Country
China
ProdList
66
Advantage
58
ANHUI JINGKE BIOTECHNOLOGY CO.,LTD
Tel
0551-65206518 18133676923
Email
taozz@kingobiotech.com
Country
China
ProdList
90
Advantage
58
Hubei Henghua Technology Co., Ltd.
Tel
18064208139
Email
2912268575@qq.com
Country
China
ProdList
1344
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6005
Advantage
61
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View Lastest Price from Fusidine manufacturers

HangZhou RunYan Pharma Technology Co.,LTD.
Product
Fusidine,Fusidic acid 6990-06-3
Price
US $0.00-0.00/g
Min. Order
10000g
Purity
99.0%min. HPLC
Supply Ability
1000kg
Release date
2024-09-12
Sinoway Industrial co., ltd.
Product
Fusidic Acid 6990-06-3
Price
US $0.00/Kg/Bag
Min. Order
2Kg/Bag
Purity
97.5% up / EP
Supply Ability
20 tons
Release date
2021-07-23
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Fusidine 6990-06-3
Price
US $0.00/KG
Min. Order
1KG
Purity
97.5%-101%; EP
Supply Ability
100KGS
Release date
2021-06-17

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