Fusidine
Mode of action- Product Name
- Fusidine
- CAS No.
- 6990-06-3
- Chemical Name
- Fusidine
- Synonyms
- FUSIDIC ACID;Fusidinic acid;(Z)-2-((3R,4S,5S,8S,9S,10S,11R,13R,14S,16S)-16-Acetoxy-3,11-dihydroxy-4,8,10,14-tetramethyldodecahydro-1H-cyclopenta[a]phenanthren-17(2H,10H,14H)-ylidene)-6-methylhept-5-enoic acid;Fusidic acid CRS;29-NordaMMara-17(20),24-dien-21-oicacid, 16-(acetyloxy)-3,11-dihydroxy-, (3a,4a,8a,9b,11a,13a,14b,16b,17Z)-;(3ALPHA,4ALPHA,8ALPHA,9BETA,11ALPHA,13ALPHA,14BETA,16BETA,17Z)-16-(ACETYLOXY)-3,11-DIHYDROXY-29-NORDAMMARA-17(20),24-DIEN-21-OIC ACID;sq16603;ramycin;Fuzidin;Flucidin
- CBNumber
- CB8431174
- Molecular Formula
- C31H48O6
- Formula Weight
- 516.72
- MOL File
- 6990-06-3.mol
Fusidine Property
- Melting point:
- 190-192°C
- Boiling point:
- 521.49°C (rough estimate)
- alpha
- D20 -9° (chloroform)
- Density
- 1.0389 (rough estimate)
- vapor pressure
- 0-0Pa at 25℃
- refractive index
- 1.4890 (estimate)
- storage temp.
- Sealed in dry,2-8°C
- solubility
- Practically insoluble in water, freely soluble in ethanol (96 per cent)
- pka
- pK: 5.35 in water
- form
- Solid
- color
- White to Off-White
- optical activity
- -920 (c 1, CHCl3)
- Water Solubility
- 2.376-525000μg/L at 25℃
- λmax
- 204nm(H2O)(lit.)
- Merck
- 14,4317
- Stability:
- Hygroscopic
- LogP
- 2.68-6.75 at 20℃
- CAS DataBase Reference
- 6990-06-3(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- Y0001411
- Product name
- Fusidic acid
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- y0001411
- Price
- $220
- Updated
- 2024/03/01
- Product number
- Y0001394
- Product name
- Fusidic acid for peak identification
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- y0001394
- Price
- $153
- Updated
- 2024/03/01
- Product number
- PHR2810
- Product name
- Fusidic acid
- Purity
- certified reference material, pharmaceutical secondary standard
- Packaging
- 50MG
- Price
- $344
- Updated
- 2024/03/01
- Product number
- F1007
- Product name
- Fusidic Acid
- Purity
- >97.0%(HPLC)(T)
- Packaging
- 1g
- Price
- $230
- Updated
- 2024/03/01
- Product number
- F1007
- Product name
- Fusidic Acid
- Purity
- >97.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $809
- Updated
- 2024/03/01
Fusidine Chemical Properties,Usage,Production
Mode of action
Fusidic acid forms a stable complex with an elongation factor (EF-G) involved in translocation and with guanosine triphosphate (GTP), which provides energy for the translocation process. One round of translocation occurs, with hydrolysis of GTP, but the fusidic acid–EF-G–GDP complex cannot dissociate from the ribosome, thereby blocking further chain elongation and leaving peptidyl-tRNA in the P site.
Although protein synthesis in Gram-negative bacilli–and, indeed, mammalian cells–is susceptible to fusidic acid, the antibiotic penetrates poorly into these cells and the spectrum of action is virtually restricted to Gram-positive bacteria, notably staphylococci.
Description
Fusidic acid was found in the culture broth of a fungus imperfectus, Fusidium coccineum, by Leo in 1962. It has a steroid struc ture but shows no hormonal activity.
Chemical Properties
White Solid
Uses
antibacterial
Uses
Fusidic acid is a bacteriostatic antibiotic. Fusidic Acid suppresses nitric oxide lysis of pancreatic islet cells. Inhibits protein synthesis in prokaryotes by inhibiting the ribosome-dependent activity of G factor and translocation of peptidyl-tRNA. Dyes and metabolites.
Definition
ChEBI: A steroid antibiotic that is isolated from the fermentation broth of Fusidium coccineum.
brand name
Fucidine (Bristol-Myers Squibb).
Hazard
Moderately toxic inhibitor of translocation during protein synthesis.
Biological Activity
Fusidic acid shows very strong activity against Staphy lococcus aureus and weak activity against other gram-positive bacteria and gram-negative cocci and Mycobacterium.
Biochem/physiol Actions
Fusidic acid is a tetracyclic triterpenoid with antibiotic activity against Gram-positive bacteria. It is derived from Fusidium coccineum. It shows its activity against anaerobes, corynebacterial, Nocardia, and Neisseria species. Fusidic acid exhibits therapeutic effects against Staphylococcal infections, skin infections.
Fusidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Fusidine manufacturers
- Product
- Fusidic Acid 6990-06-3
- Price
- US $0.00/Kg/Bag
- Min. Order
- 2Kg/Bag
- Purity
- 97.5% up / EP
- Supply Ability
- 20 tons
- Release date
- 2021-07-23
- Product
- Fusidine,Fusidic acid 6990-06-3
- Price
- US $0.00-0.00/g
- Min. Order
- 10000g
- Purity
- 99.0%min. HPLC
- Supply Ability
- 1000kg
- Release date
- 2024-09-12
- Product
- Fusidine 6990-06-3
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 97.5%-101%; EP
- Supply Ability
- 100KGS
- Release date
- 2021-06-17