Fusidine

ChemicalBook > CAS DataBase List > Fusidine

Mode of action

Product Name: Fusidine
CAS No.: 6990-06-3
Chemical Name: Fusidine
Synonyms: FUSIDIC ACID;Fusidinic acid;(Z)-2-((3R,4S,5S,8S,9S,10S,11R,13R,14S,16S)-16-Acetoxy-3,11-dihydroxy-4,8,10,14-tetramethyldodecahydro-1H-cyclopenta[a]phenanthren-17(2H,10H,14H)-ylidene)-6-methylhept-5-enoic acid;Fusidic acid CRS;29-NordaMMara-17(20),24-dien-21-oicacid, 16-(acetyloxy)-3,11-dihydroxy-, (3a,4a,8a,9b,11a,13a,14b,16b,17Z)-;(3ALPHA,4ALPHA,8ALPHA,9BETA,11ALPHA,13ALPHA,14BETA,16BETA,17Z)-16-(ACETYLOXY)-3,11-DIHYDROXY-29-NORDAMMARA-17(20),24-DIEN-21-OIC ACID;sq16603;ramycin;Fuzidin;Flucidin
CBNumber: CB8431174
Molecular Formula: C31H48O6
Formula Weight: 516.72
MOL File: 6990-06-3.mol

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Fusidine Property

Melting point:: 190-192°C
Boiling point:: 521.49°C (rough estimate)
alpha: D20 -9° (chloroform)
Density: 1.0389 (rough estimate)
vapor pressure: 0-0Pa at 25℃
refractive index: 1.4890 (estimate)
storage temp.: Sealed in dry,2-8°C
solubility: Practically insoluble in water, freely soluble in ethanol (96 per cent)
pka: pK: 5.35 in water
color: White to Off-White
Water Solubility: 2.376-525000μg/L at 25℃
λmax: 204nm(H2O)(lit.)
Merck: 14,4317
Stability:: Hygroscopic
LogP: 2.68-6.75 at 20℃
CAS DataBase Reference: 6990-06-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 22
Safety Statements: 36
WGK Germany: 3
RTECS: RC1350000
HS Code: 29419000
Toxicity: LD50 in mice (g/kg): 1.2 s.c.; 1.5 orally (Godtfredsen)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: Y0001411
Product name: Fusidic acid
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: y0001411
Price: $220
Updated: 2024/03/01

Sigma-Aldrich

Product number: Y0001394
Product name: Fusidic acid for peak identification
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: y0001394
Price: $153
Updated: 2024/03/01

Sigma-Aldrich

Product number: PHR2810
Product name: Fusidic acid
Purity: certified reference material, pharmaceutical secondary standard
Packaging: 50MG
Price: $344
Updated: 2024/03/01

TCI Chemical

Product number: F1007
Product name: Fusidic Acid
Purity: >97.0%(HPLC)(T)
Packaging: 1g
Price: $230
Updated: 2024/03/01

TCI Chemical

Product number: F1007
Product name: Fusidic Acid
Purity: >97.0%(HPLC)(T)
Packaging: 5g
Price: $809
Updated: 2024/03/01

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Fusidine Chemical Properties,Usage,Production

Mode of action

Fusidic acid forms a stable complex with an elongation factor (EF-G) involved in translocation and with guanosine triphosphate (GTP), which provides energy for the translocation process. One round of translocation occurs, with hydrolysis of GTP, but the fusidic acid–EF-G–GDP complex cannot dissociate from the ribosome, thereby blocking further chain elongation and leaving peptidyl-tRNA in the P site.
Although protein synthesis in Gram-negative bacilli–and, indeed, mammalian cells–is susceptible to fusidic acid, the antibiotic penetrates poorly into these cells and the spectrum of action is virtually restricted to Gram-positive bacteria, notably staphylococci.

Description

Fusidic acid was found in the culture broth of a fungus imperfectus, Fusidium coccineum, by Leo in 1962. It has a steroid struc ture but shows no hormonal activity.

Chemical Properties

White Solid

Uses

antibacterial

Uses

Fusidic acid is a bacteriostatic antibiotic. Fusidic Acid suppresses nitric oxide lysis of pancreatic islet cells. Inhibits protein synthesis in prokaryotes by inhibiting the ribosome-dependent activity of G factor and translocation of peptidyl-tRNA. Dyes and metabolites.

Definition

ChEBI: A steroid antibiotic that is isolated from the fermentation broth of Fusidium coccineum.

brand name

Fucidine (Bristol-Myers Squibb).

Hazard

Moderately toxic inhibitor of translocation during protein synthesis.

Biological Activity

Fusidic acid shows very strong activity against Staphy lococcus aureus and weak activity against other gram-positive bacteria and gram-negative cocci and Mycobacterium.

Biochem/physiol Actions

Fusidic acid is a tetracyclic triterpenoid with antibiotic activity against Gram-positive bacteria. It is derived from Fusidium coccineum. It shows its activity against anaerobes, corynebacterial, Nocardia, and Neisseria species. Fusidic acid exhibits therapeutic effects against Staphylococcal infections, skin infections.

Fusidine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Fusidine manufacturers

Sinoway Industrial co., ltd.

Product: Fusidic Acid 6990-06-3
Price: US $0.00/Kg/Bag
Min. Order: 2Kg/Bag
Purity: 97.5% up / EP
Supply Ability: 20 tons
Release date: 2021-07-23

Shaanxi TNJONE Pharmaceutical Co., Ltd

Product: Fusidic acid 6990-06-3
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000kg
Release date: 2024-04-24

Shaanxi TNJONE Pharmaceutical Co., Ltd

Product: Fusidine 6990-06-3
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000kg
Release date: 2024-04-12

6990-06-3, FusidineRelated Search:

Fusidic Acid Impurity J(EP) 16-Epidesacetylfusidic acid Fusidic Acid Impurity B(EP) Fusidic Acid Impurity E(EP) (3α,4α,8α,9β,13α,14β,16β,17Z)-16-(Acetyloxy)-3-hydroxy-29-nordaMMara-17(20),24-dien-21-oic Acid (8α,13α,14β,17Z)-16β-Acetoxy-3α-hydroxy-9,11-didehydro-29-nor-5α-dammara-17(20),24-dien-21-oic acid 11-monoketofusidic acid 26-Oxofusidic acid, Fusidic acid EP Impurity F 24,25-Dihydroxyfusidic Acid Diethanolamine Fusidate 16-Deacetyl Fusidic Acid Sodium Salt 2,7-dimethyl-2,6-octadiene 3-KETOFUSIDIC ACID Fusidine Sodium fusidate cicrotoic acid DIHYDROCARVEOL (2E)-3-CYCLOHEXYLPROP-2-ENOIC ACID

4-alpha,8-alpha,9-beta,11-alpha,13-alpha,14-beta,16-beta,17z)-ph

ramycin

sq16603

(3ALPHA,4ALPHA,8ALPHA,9BETA,11ALPHA,13ALPHA,14BETA,16BETA,17Z)-16-(ACETYLOXY)-3,11-DIHYDROXY-29-NORDAMMARA-17(20),24-DIEN-21-OIC ACID

FUSIDIC ACID

29-NordaMMara-17(20),24-dien-21-oicacid, 16-(acetyloxy)-3,11-dihydroxy-, (3a,4a,8a,9b,11a,13a,14b,16b,17Z)-

Fusidic acid for peak identification

Fusidic acid, 98.5%

(Z)-2-((3R,4S,5S,8S,9S,10S,11R,13R,14S,16S)-16-Acetoxy-3,11-dihydroxy-4,8,10,14-tetramethyldodecahydro-1H-cyclopenta[a]phenanthren-17(2H,10H,14H)-ylidene)-6-methylhept-5-enoic acid

-16-Acetoxy-3,11-dihydroxy-4,8,10,14-tetramethyldodecahydro-1H-cyclopenta[a]phenanthren-17(2H,10H,14H)

-2-((3R,4S,5S,8S,9S,10S,11R,13R,14S,16S)

-6-methylhept-5-enoic acid

29-Nordammara-17(20),24-dien-21-oic acid, 16-(acetyloxy)-3,11-dihydroxy-, (3α,4α,8α,9β,11α,13α,14β,16β,17Z)-

(3a,4a,8a,9b,11a,13a,14b,16b,17Z)-16-(Acetyloxy)-3,11-dihydroxy-29-nordammara-17(20),24-dien-21-oic Acid

Flucidin

Fucithalmic

Fusidinic acid

NSC 56192

29-Nordammara-17(20),24-dien-21-oic acid, 16-(acetyloxy)-3,11-dihydroxy-, (3.alpha.,4.alpha.,8.alpha.,9.beta.,11.alpha.,13.alpha.,14.beta.,16.beta.,17Z)-

16-(Acetyloxy)-3,11-dihydroxy-29-nordammara-17(20),24-dien-21-oic acid

Fusidine

24-dien-21-oicacid,16-(acetyloxy)-3,11-dihydroxy-29-nordammara-17(20(3-al

FUSIDIC ACID IP

(4S,8α,9β,13α,14β,17Z)-16β-Acetoxy-3α,11α-dihydroxy-29-nor-5α-dammara-17(20),24-dien-21-oic acid

(8α,9β,13α,14β,Z)-16β-Acetyloxy-3α,11α-dihydroxy-29-nordammara-17(20),24-dien-21-oic acid

Fuzidin

Fusidate Acid

Pyzidieb acid

(3a,4a,8a,9,11a,13a,147,167,17Z)-16-(Acetyloxy)-3,11-dihydroxy-29-nordammara-17(20),24-dien-21-oic Acid

(3α,4α,8α,9β,11α,13α,147β,167β,17Z)-16-(Acetyloxy)-3,11-dihydroxy-29-nordaMMara-17(20),24-dien-21-oic Acid

Fusidic acid for peak identification CRS

FusidicAcid&gt

Fusidic acid CRS

Fusidine USP/EP/BP

Fusidine,Fusidic acid

Fusidic acid-D6Q: What is Fusidic acid-D6 Q: What is the CAS Number of Fusidic acid-D6 Q: What is the storage condition of Fusidic acid-D6

Fusidic AcidQ: What is Fusidic Acid Q: What is the CAS Number of Fusidic Acid Q: What is the storage condition of Fusidic Acid Q: What are the applications of Fusidic Acid

fusidicaci

Amlexanox Impurity 7

6990-06-3

3990-06-3

6990-6-3

C31H48O6

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