APRINDINE HCL
- Product Name
- APRINDINE HCL
- CAS No.
- 33237-74-0
- Chemical Name
- APRINDINE HCL
- Synonyms
- ms-5075;fiboran;aspenon;Fibocil;Amidonal;Aprindina;APRINDINE HCL;Compound 83846;APRINDINE HYDROCHLORIDE;APRINDINE HCL ISO 9001：2015 REACH
- CBNumber
- CB8440044
- Molecular Formula
- C22H31ClN2
- Formula Weight
- 358.95
- MOL File
- 33237-74-0.mol
APRINDINE HCL Property
- Melting point:
- 120-121°
- storage temp.
- 2-8°C
- solubility
- H2O: >10mg/mL
- form
- solid
- color
- Light Brown to Brown
- Stability:
- Hygroscopic
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26
- WGK Germany
- 3
- RTECS
- TX7386000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A7606
- Product name
- Aprindine hydrochloride
- Purity
- ≥98% (HPLC), solid
- Packaging
- 10mg
- Price
- $188
- Updated
- 2024/03/01
- Product number
- A7606
- Product name
- Aprindine hydrochloride
- Purity
- ≥98% (HPLC), solid
- Packaging
- 50mg
- Price
- $736
- Updated
- 2024/03/01
- Product number
- 162668
- Product name
- Aprindine Hydrochloride
- Packaging
- 50mg
- Price
- $701
- Updated
- 2021/12/16
- Product number
- A729900
- Product name
- Aprindine hydrochloride
- Packaging
- 250mg
- Price
- $1295
- Updated
- 2021/12/16
- Product number
- API0025936
- Product name
- APRINDINE HYDROCHLORIDE
- Purity
- 95.00%
- Packaging
- 1MG
- Price
- $597.89
- Updated
- 2021/12/16
APRINDINE HCL Chemical Properties,Usage,Production
Originator
Amidonal,Madaus,W. Germany,1976
Uses
Aprindine is a long-acting antiarrhythmic agent, effective when administered orally or intravenously in the treatment of ventricular arrhythmias of varying etiologies.
Definition
ChEBI: Aprindine hydrochloride is a member of indanes.
Manufacturing Process
104.6 g (0.5 mol) N-phenyl-2-aminoindane and 2.5 liters benzene are
introduced into a reaction vessel of 5 liters, under an atmosphere of nitrogen.
37 g (0.95 mol) sodium amide are added and the mixture is stirred during 3
hours at room temperature.
119.7 g (0.8 mol) of γ-chloropropyl diethylamine are then quickly added. After
agitation during 1 hour at room temperature, the reaction mixture is refluxed
and stirred under nitrogen during 21 hours. The mixture is then allowed to
cool and poured onto ice. The obtained aqueous phase is extracted by means
of 500 cm3 of benzene. The benzene extract is washed two times with 200
cm3 of water and the benzene is then evaporated.
The residue is treated with 500 cm3 of hydrochloric acid (2 N). The obtained
solution is evaporated to dryness and the oily residue is recrystallized from
ethanol. 176.9 g (yield 89.4%) of dihydrochloride of N-phenyl-Ndiethylaminopropyl-
2-aminoindane are obtained, MP 208° to 210°C.
The dihydrochloride is converted into monohydrochloride by dissolving 26.36 g
(0.066 mol) of dihydrochloride into 158 cm3 of water, adding drop by drop a
suitable amount (0.066 mol) of caustic soda (1 N), evaporating the aqueous
solution to dryness, drying by means of benzene, filtering the formed sodium
chloride (3.8 g) and crystallizing the cooled obtained benzene solution. 22.6 g
(95%) of monohydrochloride are obtained, MP 120° to 121°C.
brand name
Fibocil (Lilly).
Therapeutic Function
Antiarrhythmic
APRINDINE HCL Preparation Products And Raw materials
Raw materials
Preparation Products
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