APRINDINE HCL

Product Name: APRINDINE HCL
CAS No.: 33237-74-0
Chemical Name: APRINDINE HCL
Synonyms: ms-5075;fiboran;aspenon;Fibocil;Amidonal;Aprindina;APRINDINE HCL;Compound 83846;APRINDINE HYDROCHLORIDE;APRINDINE HCL ISO 9001：2015 REACH
CBNumber: CB8440044
Molecular Formula: C22H31ClN2
Formula Weight: 358.95
MOL File: 33237-74-0.mol

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APRINDINE HCL Property

Melting point:: 120-121°
storage temp.: 2-8°C
solubility: H2O: >10mg/mL
form: solid
color: Light Brown to Brown
Stability:: Hygroscopic

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Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38
Safety Statements: 26
WGK Germany: 3
RTECS: TX7386000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A7606
Product name: Aprindine hydrochloride
Purity: ≥98% (HPLC), solid
Packaging: 10mg
Price: $188
Updated: 2024/03/01

Sigma-Aldrich

Product number: A7606
Product name: Aprindine hydrochloride
Purity: ≥98% (HPLC), solid
Packaging: 50mg
Price: $736
Updated: 2024/03/01

Usbiological

Product number: 162668
Product name: Aprindine Hydrochloride
Packaging: 50mg
Price: $701
Updated: 2021/12/16

TRC

Product number: A729900
Product name: Aprindine hydrochloride
Packaging: 250mg
Price: $1295
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0025936
Product name: APRINDINE HYDROCHLORIDE
Purity: 95.00%
Packaging: 1MG
Price: $597.89
Updated: 2021/12/16

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APRINDINE HCL Chemical Properties,Usage,Production

Originator

Amidonal,Madaus,W. Germany,1976

Uses

Aprindine is a long-acting antiarrhythmic agent, effective when administered orally or intravenously in the treatment of ventricular arrhythmias of varying etiologies.

Definition

ChEBI: Aprindine hydrochloride is a member of indanes.

Manufacturing Process

104.6 g (0.5 mol) N-phenyl-2-aminoindane and 2.5 liters benzene are introduced into a reaction vessel of 5 liters, under an atmosphere of nitrogen. 37 g (0.95 mol) sodium amide are added and the mixture is stirred during 3 hours at room temperature.
119.7 g (0.8 mol) of γ-chloropropyl diethylamine are then quickly added. After agitation during 1 hour at room temperature, the reaction mixture is refluxed and stirred under nitrogen during 21 hours. The mixture is then allowed to cool and poured onto ice. The obtained aqueous phase is extracted by means of 500 cm3 of benzene. The benzene extract is washed two times with 200 cm3 of water and the benzene is then evaporated.
The residue is treated with 500 cm3 of hydrochloric acid (2 N). The obtained solution is evaporated to dryness and the oily residue is recrystallized from ethanol. 176.9 g (yield 89.4%) of dihydrochloride of N-phenyl-Ndiethylaminopropyl- 2-aminoindane are obtained, MP 208° to 210°C.
The dihydrochloride is converted into monohydrochloride by dissolving 26.36 g (0.066 mol) of dihydrochloride into 158 cm3 of water, adding drop by drop a suitable amount (0.066 mol) of caustic soda (1 N), evaporating the aqueous solution to dryness, drying by means of benzene, filtering the formed sodium chloride (3.8 g) and crystallizing the cooled obtained benzene solution. 22.6 g (95%) of monohydrochloride are obtained, MP 120° to 121°C.

brand name

Fibocil (Lilly).

Therapeutic Function

Antiarrhythmic

APRINDINE HCL Preparation Products And Raw materials

Raw materials

Preparation Products

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APRINDINE HCL Suppliers

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33237-74-0, APRINDINE HCLRelated Search:

Isopropylamine Dipropylamine Propylamine Sertraline hydrochloride 1H-INDEN-2-AMINE, N-ETHYL-2,3-DIHYDRO- Aprindine APRINDINE HCL N-PHENYL-2-AMINOINDAN 2-Aminoindan hydrochloride

fiboran

ms-5075

n-(3-(diethylamino)propyl)-n-phenyl-2-indanaminhydrochloride

n,n-diethyl-n’-2-indanyl-n’-phenyl-1,3-propanediaminehydrochloride

APRINDINE HCL

APRINDINE HYDROCHLORIDE

N-(2,3-dihydro-1H-inden-2-yl)-N',N'-diethyl-N-phenylpropane-1,3-diamine monohydrochloride

Amidonal

N-(2,3-Dihydro-1H-inden-2-yl)-N′,N′-diethyl-N-phenyl-1,3-propanediamine hydrochloride

Compound 83846

3-propanediamine,n-(2,3-dihydro-1h-inden-2-yl)-n’,n’-diethyl-n-phenyl-mo

3-propanediamine,n,n-diethyl-n’-2-indanyl-n’-phenyl-monohydrochloride

aspenon

APRINDINE HCL ISO 9001：2015 REACH

Aprindina

Fibocil

33237-74-0

C22H31ClN2

C22H30N2HCl

35895

pharmacetical