NEORUSCOGENIN
- Product Name
- NEORUSCOGENIN
- CAS No.
- 17676-33-4
- Chemical Name
- NEORUSCOGENIN
- Synonyms
- NEORUSCOGENIN;Einecs 241-660-1;spirost-5,25(27)-dien-1β,3β-diol;spirost-5,25(27)-dien-1β,3β-diol;SPIROSTA-5,25(27)-DIENE-1B,3B-DIOL;Spirosta-5,25(27)-diene-1β,3β-diol;spirosta-5,25(27)-diene-1beta,3beta-diol;Spirosta-5,25(27)-diene-1,3-diol,(1b,3b)-;Spirosta-5,25(27)-diene-1,3-diol, (1β,3β)-;Spirosta-5,25(27)-diene-1,3-diol, (1.beta.,3.beta.)-
- CBNumber
- CB8440721
- Molecular Formula
- C27H40O4
- Formula Weight
- 428.61
- MOL File
- 17676-33-4.mol
NEORUSCOGENIN Property
- Melting point:
- 196～198℃
- Density
- 1.19±0.1 g/cm3 (20 ºC 760 Torr)
- storage temp.
- 4°C, protect from light
- solubility
- ≤30mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide
- form
- crystalline solid
- Boiling point:
- 566.6±50.0 °C(Predicted)
- pka
- 14.55±0.70(Predicted)
- LogP
- 4.210 (est)
Safety
- HS Code
- 29329990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 15567
- Product name
- Neoruscogenin
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $120
- Updated
- 2024/03/01
- Product number
- 15567
- Product name
- Neoruscogenin
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $477
- Updated
- 2024/03/01
- Product number
- 15567
- Product name
- Neoruscogenin
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $834
- Updated
- 2024/03/01
- Product number
- 285002
- Product name
- Neoruscogenin
- Packaging
- 5mg
- Price
- $333
- Updated
- 2021/12/16
- Product number
- N390150
- Product name
- Neoruscogenin
- Packaging
- 5mg
- Price
- $360
- Updated
- 2021/12/16
NEORUSCOGENIN Chemical Properties,Usage,Production
Uses
Neoruscogenin is a natural sapogenin isolated from Butcher’s broom (R. rhizoma), which is traditionally used against chronic venous disorders.
Biological Activity
neoruscogenin is a bioavailable, potent, and high-affinity agonist of the nuclear receptor rorα [1]. neoruscogenin is a natural sapogenin extracted from butcher’s broom (rusci rhizoma, ruscus aculeatus, ruscaceae) [2].rar-related orphan receptor alpha (rorα) is a nuclear receptor that participates in the transcriptional regulation of some genes involved incircadian rhythm. genetic studies have revealed that rorα plays an important role in the development of the central nervous system and has been associated with genetic lesions in mice [3].
in vitro
in confluent human microvascular endothelial cells (hmec-1), pre-treatment with neoruscogenin slightly decreased the permeability at concentrations up to 100 μm (71.8%). the ec50 of neoruscogenin against the nuclear receptor rorα was 110 nm [1].
in vivo
in mice, oral administration of neoruscogenin (3 mg/kg/d) for seven days up-regulated the expression of several rorα-inducible genes in the liver [1].
References
[1] helleboid s, haug c, lamottke k, et al. the identification of naturally occurring neoruscogenin as a bioavailable, potent, and high-affinity agonist of the nuclear receptor rorα (nr1f1)[j]. journal of biomolecular screening, 2013: 1087057113497095.
[2] barbi m, willer e a, rothenhfer m, et al. spirostanol saponins and esculin from rusci rhizoma reduce the thrombin-induced hyperpermeability of endothelial cells[j]. phytochemistry, 2013, 90: 106-113.
[3] giguère v. orphan nuclear receptors: from gene to function 1[j]. endocrine reviews, 1999, 20(5): 689-725.
NEORUSCOGENIN Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from NEORUSCOGENIN manufacturers
- Product
- Neoruscogenin 17676-33-4
- Price
- US $0.00/mg
- Min. Order
- 20mg
- Purity
- ≥98%(HPLC)
- Supply Ability
- 10 g
- Release date
- 2020-04-26
- Product
- NEORUSCOGENIN 17676-33-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 25kg
- Release date
- 2019-07-12