Resibufogenin
- Product Name
- Resibufogenin
- CAS No.
- 465-39-4
- Chemical Name
- Resibufogenin
- Synonyms
- rbg;Respigon;BUFOGENIN;bufogenina;Resibufogin;RESIBUFOGENIN;Resibufogeninc;RESIBUFOGENIN95%,97%;Resibufogenin USP/EP/BP;BUFOGENIN; RESIBUFOGENIN
- CBNumber
- CB6254472
- Molecular Formula
- C24H32O4
- Formula Weight
- 384.51
- MOL File
- 465-39-4.mol
Resibufogenin Property
- Melting point:
- 113-140°/155-168°
- alpha
- D22 -7.1° (c = 1.259 in chloroform); D16 -5.4° (c = 2.030 in chloroform)
- Boiling point:
- 431.17°C (rough estimate)
- Density
- 1.0474 (rough estimate)
- refractive index
- 1.4860 (estimate)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- DMF: 25 mg/mL; DMF:PBS(pH 7.2)(1:1): 0.5 mg/mL; DMSO: 20 mg/mL; Ethanol: 5 mg/mL
- form
- White to off-white solid.
- pka
- 15.14±0.70(Predicted)
- Stability:
- Moisture Sensitive
Safety
- Safety Statements
- 24/25
- RIDADR
- 3172
- HazardClass
- 6.1(a)
- PackingGroup
- II
- HS Code
- 29322090
- Toxicity
- LD50 oral in mouse: 59800mg/kg
N-Bromosuccinimide Price
- Product number
- PHL89774
- Product name
- Resibufogenin
- Purity
- phyproof? Reference Substance
- Packaging
- 10MG
- Price
- $539
- Updated
- 2024/03/01
- Product number
- 9001348
- Product name
- Resibufogenin
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $36
- Updated
- 2024/03/01
- Product number
- 9001348
- Product name
- Resibufogenin
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $134
- Updated
- 2024/03/01
- Product number
- 9001348
- Product name
- Resibufogenin
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $197
- Updated
- 2024/03/01
- Product number
- 9001348
- Product name
- Resibufogenin
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $1146
- Updated
- 2023/06/20
Resibufogenin Chemical Properties,Usage,Production
Description
As one of the active components of Bufonis bufa, Resibufogenin is speculated that Etobufaxin can inhibit the proliferation of tumor cells by inducing apoptosis of osteosarcoma cells.
Uses
Resibufogenin is used for content determination/identification/pharmacological experiments, etc.
Definition
ChEBI: Bufogenin is a steroid lactone of Chan su (toad venom), a Chinese medicine obtained from the skin venom gland of toads. A specific Na/K-ATPase protein inhibitor, it is used as a cardiotonic and central nervous system (CNS) respiratory agent, an analgesic and anesthetic, and as a remedy for ulcers. It has a role as an EC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor. It is a steroid lactone and an epoxy steroid. It is functionally related to a bufanolide.
Biological Activity
Resibufogenin (Bufogenin, Recibufogenin) is the anticancer component of huachansu cinobufogenin, which triggers necrosis by up-regulating receptor-interacting protein kinase 3 (RIP3) and phosphorylating Ser358 of mixed lineage kinase domain-like protein. It exerts cytotoxic effects by inducing the accumulation of reactive oxygen species (ROS). Resibufogenin induces apoptosis and caspase-3 and caspase-8 activity. Also it increases Bax/Bcl-2 expression and inhibits protein expression of cyclin D1, cyclin E, PI3K, p-AKT, p-GSK3β and β-catenin.
Pharmacokinetics
The main pharmacological action of acetobufaxin is anti-tumor. The cinobufavidin injection was separated by modern chromatographic techniques, and the exobufaxin compounds were obtained. The main monomers of exobufaxin were analyzed and identified by HPLC-DAD-FT-ICR-MS. The anti-tumor activity of exobufaxin was screened in vitro, and the pancreatic cancer tumor-bearing nude mouse model was established in vivo to evaluate the efficacy of exobufaxin.
target
| Target | Value |
| RIP3 () | |
| MLK () | |
| ROS () | |
| Caspase-3 () | |
| Caspase-8 () | |
| |
Resibufogenin Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Resibufogenin manufacturers
- Product
- Resibufogenin 465-39-4
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-06
- Product
- Resibufogenin 465-39-4
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 95%-99%
- Supply Ability
- 100kg
- Release date
- 2018-12-24