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Resibufogenin

Product Name
Resibufogenin
CAS No.
465-39-4
Chemical Name
Resibufogenin
Synonyms
rbg;Respigon;BUFOGENIN;bufogenina;Resibufogin;RESIBUFOGENIN;Resibufogeninc;Resibufogenin-RM;RESIBUFOGENIN95%,97%;Resibufogenin USP/EP/BP
CBNumber
CB6254472
Molecular Formula
C24H32O4
Formula Weight
384.51
MOL File
465-39-4.mol
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Resibufogenin Property

Melting point:
113-140°/155-168°
alpha 
D22 -7.1° (c = 1.259 in chloroform); D16 -5.4° (c = 2.030 in chloroform)
Boiling point:
431.17°C (rough estimate)
Density 
1.0474 (rough estimate)
refractive index 
1.4860 (estimate)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
DMF: 25 mg/mL; DMF:PBS(pH 7.2)(1:1): 0.5 mg/mL; DMSO: 20 mg/mL; Ethanol: 5 mg/mL
form 
White to off-white solid.
pka
15.14±0.70(Predicted)
color 
White to off-white
Stability:
Moisture Sensitive
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Safety

Safety Statements 
24/25
RIDADR 
3172
HazardClass 
6.1(a)
PackingGroup 
II
HS Code 
29322090
Toxicity
LD50 oral in mouse: 59800mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P262Do not get in eyes, on skin, or on clothing.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHL89774
Product name
Resibufogenin
Purity
phyproof? Reference Substance
Packaging
10MG
Price
$539
Updated
2024/03/01
Cayman Chemical
Product number
9001348
Product name
Resibufogenin
Purity
≥98%
Packaging
1mg
Price
$36
Updated
2024/03/01
Cayman Chemical
Product number
9001348
Product name
Resibufogenin
Purity
≥98%
Packaging
5mg
Price
$134
Updated
2024/03/01
Cayman Chemical
Product number
9001348
Product name
Resibufogenin
Purity
≥98%
Packaging
10mg
Price
$197
Updated
2024/03/01
Cayman Chemical
Product number
9001348
Product name
Resibufogenin
Purity
≥98%
Packaging
50mg
Price
$1146
Updated
2023/06/20
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Resibufogenin Chemical Properties,Usage,Production

Description

As one of the active components of Bufonis bufa, Resibufogenin is speculated that Etobufaxin can inhibit the proliferation of tumor cells by inducing apoptosis of osteosarcoma cells.

Uses

Resibufogenin is used for content determination/identification/pharmacological experiments, etc.

Definition

ChEBI: Bufogenin is a steroid lactone of Chan su (toad venom), a Chinese medicine obtained from the skin venom gland of toads. A specific Na/K-ATPase protein inhibitor, it is used as a cardiotonic and central nervous system (CNS) respiratory agent, an analgesic and anesthetic, and as a remedy for ulcers. It has a role as an EC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor. It is a steroid lactone and an epoxy steroid. It is functionally related to a bufanolide.

Biological Activity

Resibufogenin (Bufogenin, Recibufogenin) is the anticancer component of huachansu cinobufogenin, which triggers necrosis by up-regulating receptor-interacting protein kinase 3 (RIP3) and phosphorylating Ser358 of mixed lineage kinase domain-like protein. It exerts cytotoxic effects by inducing the accumulation of reactive oxygen species (ROS). Resibufogenin induces apoptosis and caspase-3 and caspase-8 activity. Also it increases Bax/Bcl-2 expression and inhibits protein expression of cyclin D1, cyclin E, PI3K, p-AKT, p-GSK3β and β-catenin.

Pharmacokinetics

The main pharmacological action of acetobufaxin is anti-tumor. The cinobufavidin injection was separated by modern chromatographic techniques, and the exobufaxin compounds were obtained. The main monomers of exobufaxin were analyzed and identified by HPLC-DAD-FT-ICR-MS. The anti-tumor activity of exobufaxin was screened in vitro, and the pancreatic cancer tumor-bearing nude mouse model was established in vivo to evaluate the efficacy of exobufaxin.

target

TargetValue
RIP3
()
MLK
()
ROS
()
Caspase-3
()
Caspase-8
()

Resibufogenin Preparation Products And Raw materials

Raw materials

Preparation Products

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Resibufogenin Suppliers

Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6005
Advantage
61
Aktin Chemicals, Inc.
Tel
86-28-85159085
Fax
86-28-85152372
Email
info@aktinchem.com
Country
China
ProdList
297
Advantage
62
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
meilunui@163.com
Country
China
ProdList
4727
Advantage
58
BioBioPha Co., Ltd.
Tel
0871-65217109 13211707573;
Fax
0871-65215563
Email
y.liu@mail.biobiopha.com
Country
China
ProdList
5653
Advantage
65
ShangHai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847 13636370518
Fax
021-55068248
Email
shyysw007@163.com
Country
China
ProdList
4940
Advantage
60
Chengdu Biopurify Phytochemicals Ltd.
Tel
+86-028-82633397 18982077548
Fax
+86-28-82633165
Email
cwb1@biopurify.cn
Country
China
ProdList
2376
Advantage
60
Chengdu Climax Biotech Co., Ltd.
Tel
028-83311324 1278112614
Fax
028-83311324
Email
climaxbiotech@gmail.com
Country
China
ProdList
925
Advantage
58
Shanghai Winherb Medical Technology Co., Ltd.
Tel
400-400-186-5138 13341702378
Fax
QQ:190129269
Email
winherb@126.com
Country
China
ProdList
1009
Advantage
58
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12335
Advantage
58
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
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View Lastest Price from Resibufogenin manufacturers

Career Henan Chemical Co
Product
Resibufogenin 465-39-4
Price
US $1.00/kg
Min. Order
1kg
Purity
95%-99%
Supply Ability
100kg
Release date
2018-12-24

465-39-4, ResibufogeninRelated Search:


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