ChemicalBook > CAS DataBase List > Resibufogenin

Resibufogenin

Product Name
Resibufogenin
CAS No.
465-39-4
Chemical Name
Resibufogenin
Synonyms
rbg;Respigon;BUFOGENIN;bufogenina;Resibufogin;RESIBUFOGENIN;Resibufogeninc;RESIBUFOGENIN95%,97%;Resibufogenin USP/EP/BP;BUFOGENIN; RESIBUFOGENIN
CBNumber
CB6254472
Molecular Formula
C24H32O4
Formula Weight
384.51
MOL File
465-39-4.mol
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Resibufogenin Property

Melting point:
113-140°/155-168°
alpha 
D22 -7.1° (c = 1.259 in chloroform); D16 -5.4° (c = 2.030 in chloroform)
Boiling point:
431.17°C (rough estimate)
Density 
1.0474 (rough estimate)
refractive index 
1.4860 (estimate)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
DMF: 25 mg/mL; DMF:PBS(pH 7.2)(1:1): 0.5 mg/mL; DMSO: 20 mg/mL; Ethanol: 5 mg/mL
form 
White to off-white solid.
pka
15.14±0.70(Predicted)
Stability:
Moisture Sensitive
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Safety

Safety Statements 
24/25
RIDADR 
3172
HazardClass 
6.1(a)
PackingGroup 
II
HS Code 
29322090
Toxicity
LD50 oral in mouse: 59800mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P262Do not get in eyes, on skin, or on clothing.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHL89774
Product name
Resibufogenin
Purity
phyproof? Reference Substance
Packaging
10MG
Price
$539
Updated
2024/03/01
Cayman Chemical
Product number
9001348
Product name
Resibufogenin
Purity
≥98%
Packaging
1mg
Price
$36
Updated
2024/03/01
Cayman Chemical
Product number
9001348
Product name
Resibufogenin
Purity
≥98%
Packaging
5mg
Price
$134
Updated
2024/03/01
Cayman Chemical
Product number
9001348
Product name
Resibufogenin
Purity
≥98%
Packaging
10mg
Price
$197
Updated
2024/03/01
Cayman Chemical
Product number
9001348
Product name
Resibufogenin
Purity
≥98%
Packaging
50mg
Price
$1146
Updated
2023/06/20
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Resibufogenin Chemical Properties,Usage,Production

Description

As one of the active components of Bufonis bufa, Resibufogenin is speculated that Etobufaxin can inhibit the proliferation of tumor cells by inducing apoptosis of osteosarcoma cells.

Uses

Resibufogenin is used for content determination/identification/pharmacological experiments, etc.

Definition

ChEBI: Bufogenin is a steroid lactone of Chan su (toad venom), a Chinese medicine obtained from the skin venom gland of toads. A specific Na/K-ATPase protein inhibitor, it is used as a cardiotonic and central nervous system (CNS) respiratory agent, an analgesic and anesthetic, and as a remedy for ulcers. It has a role as an EC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor. It is a steroid lactone and an epoxy steroid. It is functionally related to a bufanolide.

Biological Activity

Resibufogenin (Bufogenin, Recibufogenin) is the anticancer component of huachansu cinobufogenin, which triggers necrosis by up-regulating receptor-interacting protein kinase 3 (RIP3) and phosphorylating Ser358 of mixed lineage kinase domain-like protein. It exerts cytotoxic effects by inducing the accumulation of reactive oxygen species (ROS). Resibufogenin induces apoptosis and caspase-3 and caspase-8 activity. Also it increases Bax/Bcl-2 expression and inhibits protein expression of cyclin D1, cyclin E, PI3K, p-AKT, p-GSK3β and β-catenin.

Pharmacokinetics

The main pharmacological action of acetobufaxin is anti-tumor. The cinobufavidin injection was separated by modern chromatographic techniques, and the exobufaxin compounds were obtained. The main monomers of exobufaxin were analyzed and identified by HPLC-DAD-FT-ICR-MS. The anti-tumor activity of exobufaxin was screened in vitro, and the pancreatic cancer tumor-bearing nude mouse model was established in vivo to evaluate the efficacy of exobufaxin.

target

TargetValue
RIP3
()
MLK
()
ROS
()
Caspase-3
()
Caspase-8
()

Resibufogenin Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Resibufogenin manufacturers

Dideu Industries Group Limited
Product
Resibufogenin 465-39-4
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-08-06
Career Henan Chemical Co
Product
Resibufogenin 465-39-4
Price
US $1.00/kg
Min. Order
1kg
Purity
95%-99%
Supply Ability
100kg
Release date
2018-12-24

465-39-4, ResibufogeninRelated Search:

14,15β-Epoxy-3β-hydroxy-19-oxo-5β,14β-bufa-20,22-dienolide Isocyanatocyclohexane Carbobenzoxyhydrazide Vinyl ester resin 1,2-EPOXYHEXADECANE 7-OCTEN-2-OL, 2-METHYL-6-METHYLENE 1,2-Epoxyoctadecane (R)-(+)-1,2-EPOXY-9-DECENE Cinobufagin (R)-(+)-1,2-EPOXYPENTADECANE 1-ETHOXY-1-HEPTENE Resibufogenin std. RESIBUFOGENIN(SH) Resibufogenin (R)-(+)-1,2-EPOXYTETRADECANE resibufogenin acetate Resibufogenin 3-(hydrogen suberate) (R)-(+)-1,2-EPOXYHEXADECANE

  • bufogenina
  • rbg
  • RESIBUFOGENIN
  • RESIBUFOGENIN95%,97%
  • (3BETA,5BETA,15BETA)-14,15EPOXY-3-HYDROXY-5-BUFA-20,22-DIENOLIDE
  • 20,22,5BETA-BUFADIENOLID-14BETA,15BETA-EPOXY-3BETA-OL
  • BUFOGENIN
  • 5-beta-Bufa-20,22-dienolide, 14,15-beta-epoxy-3-beta-hydroxy-
  • 14,15β-Epoxy-3β-hydroxy-5β-bufa-20,22-dienolide
  • Respigon
  • Resibufogeninc
  • BUFOGENIN; RESIBUFOGENIN
  • Resibufogenin(NSC 90783)
  • 14,15-beta-epoxy-3-beta-hydroxy-5-beta-bufa-20,22-dienolide
  • 22-dienolide,14,15-beta-epoxy-3-beta-hydroxy-5-beta-bufa-2
  • 3-beta-hydroxy-14,15-beta-epoxy-5-beta-bufa-20,22-dienolide
  • Resibufogenin, 99%, from cinobufagin venom toad
  • Resibufogin
  • Bufa-20,22-dienolide, 14,15-epoxy-3-hydroxy-, (3β,5β,15β)-
  • Resibufogenin USP/EP/BP
  • 5-((1R,2aR,3aS,3bR,5aR,7S,9aS,9bS,11aR)-7-Hydroxy-9a,11a-dimethylhexadecahydronaphtho[1',2':6,7]indeno[1,7a-b]oxiren-1-yl)-2H-pyran-2-one
  • 465-39-4
  • C24H32O4
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • Steroids