Resibufogenin

ChemicalBook > CAS DataBase List > Resibufogenin

Product Name: Resibufogenin
CAS No.: 465-39-4
Chemical Name: Resibufogenin
Synonyms: rbg;Respigon;BUFOGENIN;bufogenina;Resibufogin;RESIBUFOGENIN;Resibufogeninc;Resibufogenin-RM;RESIBUFOGENIN95%,97%;Resibufogenin USP/EP/BP
CBNumber: CB6254472
Molecular Formula: C24H32O4
Formula Weight: 384.51
MOL File: 465-39-4.mol

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Resibufogenin Property

Melting point:: 113-140°/155-168°
alpha: D22 -7.1° (c = 1.259 in chloroform); D16 -5.4° (c = 2.030 in chloroform)
Boiling point:: 431.17°C (rough estimate)
Density: 1.0474 (rough estimate)
refractive index: 1.4860 (estimate)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: DMF: 25 mg/mL; DMF:PBS(pH 7.2)(1:1): 0.5 mg/mL; DMSO: 20 mg/mL; Ethanol: 5 mg/mL
form: White to off-white solid.
pka: 15.14±0.70(Predicted)
color: White to off-white
Stability:: Moisture Sensitive

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Safety

Safety Statements: 24/25
RIDADR: 3172
HazardClass: 6.1(a)
PackingGroup: II
HS Code: 29322090
Toxicity: LD50 oral in mouse: 59800mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P262Do not get in eyes, on skin, or on clothing.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHL89774
Product name: Resibufogenin
Purity: phyproof? Reference Substance
Packaging: 10MG
Price: $539
Updated: 2024/03/01

Cayman Chemical

Product number: 9001348
Product name: Resibufogenin
Purity: ≥98%
Packaging: 1mg
Price: $36
Updated: 2024/03/01

Cayman Chemical

Product number: 9001348
Product name: Resibufogenin
Purity: ≥98%
Packaging: 5mg
Price: $134
Updated: 2024/03/01

Cayman Chemical

Product number: 9001348
Product name: Resibufogenin
Purity: ≥98%
Packaging: 10mg
Price: $197
Updated: 2024/03/01

Cayman Chemical

Product number: 9001348
Product name: Resibufogenin
Purity: ≥98%
Packaging: 50mg
Price: $1146
Updated: 2023/06/20

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Resibufogenin Chemical Properties,Usage,Production

Description

As one of the active components of Bufonis bufa, Resibufogenin is speculated that Etobufaxin can inhibit the proliferation of tumor cells by inducing apoptosis of osteosarcoma cells.

Uses

Resibufogenin is used for content determination/identification/pharmacological experiments, etc.

Definition

ChEBI: Bufogenin is a steroid lactone of Chan su (toad venom), a Chinese medicine obtained from the skin venom gland of toads. A specific Na/K-ATPase protein inhibitor, it is used as a cardiotonic and central nervous system (CNS) respiratory agent, an analgesic and anesthetic, and as a remedy for ulcers. It has a role as an EC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor. It is a steroid lactone and an epoxy steroid. It is functionally related to a bufanolide.

Biological Activity

Resibufogenin (Bufogenin, Recibufogenin) is the anticancer component of huachansu cinobufogenin, which triggers necrosis by up-regulating receptor-interacting protein kinase 3 (RIP3) and phosphorylating Ser358 of mixed lineage kinase domain-like protein. It exerts cytotoxic effects by inducing the accumulation of reactive oxygen species (ROS). Resibufogenin induces apoptosis and caspase-3 and caspase-8 activity. Also it increases Bax/Bcl-2 expression and inhibits protein expression of cyclin D1, cyclin E, PI3K, p-AKT, p-GSK3β and β-catenin.

Pharmacokinetics

The main pharmacological action of acetobufaxin is anti-tumor. The cinobufavidin injection was separated by modern chromatographic techniques, and the exobufaxin compounds were obtained. The main monomers of exobufaxin were analyzed and identified by HPLC-DAD-FT-ICR-MS. The anti-tumor activity of exobufaxin was screened in vitro, and the pancreatic cancer tumor-bearing nude mouse model was established in vivo to evaluate the efficacy of exobufaxin.

target

Target	Value
RIP3 ()
MLK ()
ROS ()
Caspase-3 ()
Caspase-8 ()
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Resibufogenin Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Resibufogenin manufacturers

Career Henan Chemical Co

Product: Resibufogenin 465-39-4
Price: US $1.00/kg
Min. Order: 1kg
Purity: 95%-99%
Supply Ability: 100kg
Release date: 2018-12-24

465-39-4, ResibufogeninRelated Search:

14,15β-Epoxy-3β-hydroxy-19-oxo-5β,14β-bufa-20,22-dienolide Isocyanatocyclohexane Carbobenzoxyhydrazide Vinyl ester resin 1,2-EPOXYHEXADECANE 7-OCTEN-2-OL, 2-METHYL-6-METHYLENE 1,2-Epoxyoctadecane (R)-(+)-1,2-EPOXY-9-DECENE Cinobufagin (R)-(+)-1,2-EPOXYPENTADECANE 1-ETHOXY-1-HEPTENE Resibufogenin std. RESIBUFOGENIN(SH) Resibufogenin (R)-(+)-1,2-EPOXYTETRADECANE resibufogenin acetate Resibufogenin 3-(hydrogen suberate) (R)-(+)-1,2-EPOXYHEXADECANE

bufogenina

rbg

RESIBUFOGENIN

RESIBUFOGENIN95%,97%

(3BETA,5BETA,15BETA)-14,15EPOXY-3-HYDROXY-5-BUFA-20,22-DIENOLIDE

20,22,5BETA-BUFADIENOLID-14BETA,15BETA-EPOXY-3BETA-OL

BUFOGENIN

5-beta-Bufa-20,22-dienolide, 14,15-beta-epoxy-3-beta-hydroxy-

14,15β-Epoxy-3β-hydroxy-5β-bufa-20,22-dienolide

Respigon

Resibufogeninc

BUFOGENIN; RESIBUFOGENIN

Resibufogenin(NSC 90783)

14,15-beta-epoxy-3-beta-hydroxy-5-beta-bufa-20,22-dienolide

22-dienolide,14,15-beta-epoxy-3-beta-hydroxy-5-beta-bufa-2

3-beta-hydroxy-14,15-beta-epoxy-5-beta-bufa-20,22-dienolide

Resibufogenin, 99%, from cinobufagin venom toad

Resibufogin

Bufa-20,22-dienolide, 14,15-epoxy-3-hydroxy-, (3β,5β,15β)-

Resibufogenin USP/EP/BP

5-((1R,2aR,3aS,3bR,5aR,7S,9aS,9bS,11aR)-7-Hydroxy-9a,11a-dimethylhexadecahydronaphtho[1',2':6,7]indeno[1,7a-b]oxiren-1-yl)-2H-pyran-2-one

Resibufogenin-RM

Resibufogenin, 10 mM in DMSO

465-39-4

C24H32O4

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract

Steroids