4-(P-IODOPHENYL)BUTYRIC ACID
Uses- Product Name
- 4-(P-IODOPHENYL)BUTYRIC ACID
- CAS No.
- 27913-58-2
- Chemical Name
- 4-(P-IODOPHENYL)BUTYRIC ACID
- Synonyms
- 4-Iodobenzenebutanoic acid;4-(P-IODOPHENYL)BUTYRIC ACID;4-(p-Lodophenyl)butyric acid;Benzenebutanoic acid, 4-iodo-;4-(p-Iodophenyl)butyric acid >=98%;4-(p-Iodophenyl)butyric acid;BENZENE DERIVATIVE(4-(P-IODOPHENYL)BUTYRIC ACID);4-(4-Iodophenyl)butanoic acid , 4-(p-Iodophenyl)butyric acid
- CBNumber
- CB8444901
- Molecular Formula
- C10H11IO2
- Formula Weight
- 290.1
- MOL File
- 27913-58-2.mol
4-(P-IODOPHENYL)BUTYRIC ACID Property
- Melting point:
- 89-89.5 °C
- Boiling point:
- 351.0±17.0 °C(Predicted)
- Density
- 1.686±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- Chloroform (Sparingly), Methanol (Slightly)
- form
- Solid
- pka
- 4.74±0.10(Predicted)
- color
- White to Pale Yellow
- InChI
- InChI=1S/C10H11IO2/c11-9-6-4-8(5-7-9)2-1-3-10(12)13/h4-7H,1-3H2,(H,12,13)
- InChIKey
- OGOMLUBUDYFIOG-UHFFFAOYSA-N
- SMILES
- C1(CCCC(O)=O)=CC=C(I)C=C1
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- I5634
- Product name
- 4-(p-Iodophenyl)butyric acid
- Purity
- ≥98%
- Packaging
- 5g
- Price
- $484
- Updated
- 2025/07/31
- Product number
- I717540
- Product name
- 4-(p-Iodophenyl)butyric acid
- Packaging
- 10g
- Price
- $325
- Updated
- 2021/12/16
- Product number
- Y1471
- Product name
- 4-(p-Iodophenyl)butyric acid
- Packaging
- 5g
- Price
- $317
- Updated
- 2021/12/16
- Product number
- 59202
- Product name
- 4-(p-Iodophenyl)butyric acid
- Packaging
- 1g
- Price
- $610
- Updated
- 2021/12/16
- Product number
- HCH0067028
- Product name
- 4-(P-IODOPHENYL)BUTYRIC ACID
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $1041.76
- Updated
- 2021/12/16
4-(P-IODOPHENYL)BUTYRIC ACID Chemical Properties,Usage,Production
Uses
4-(p-Iodophenyl)butyric Acid is a reactant involved in the synthesis of meta- and paracyclophanes containing unsaturated amino acids and intramolecular Friedel-Crafts reactions for synthesis of 1-tetralones.
Uses
Reactant involved in:• ;Synthesis of meta- and paracyclophanes containing unsaturated amino acids1• ;Intramolecular Friedel-Crafts reactions for synthesis of 1-tetralones2Involved in investigations of pharmacological activity pertaining to:• ;Apoptosis, proliferation, and histon deacetylase activity in human colorectal cancer cells3,4• ;Portable albumin binders for extending the half-life of contrast agents5
Uses
4-(p-Iodophenyl)butyric Acid is a reactant involved in the synthesis of meta- and paracyclophanes containing unsaturated amino acids and intramolecular Friedel-Crafts reactions for synthesis of 1-tetralones.
Synthesis
1821-12-1
27913-58-2
4-Phenylbutyric acid (20.0 g, 121.8 mmol) was added to a mixed solution of periodate (H5IO6, 5.56 g, 24.4 mmol), iodine (I2, 13.30 g, 52.4 mmol), 10 M sulfuric acid (H2SO4, 5.0 mL), water (36 mL), and acetic acid (166 mL), and the reaction was heated at 70 °C for 19 hours. Upon completion of the reaction, the reaction mixture was cooled and evaporated to dryness. The residue was dissolved in ethyl acetate (EtOAc, 300 mL), washed sequentially with aqueous sodium thiosulfate (Na2S2O3) (2×200 mL) and saturated saline (2×200 mL), dried with anhydrous sodium sulfate (Na2SO4), filtered, and then the solvent was evaporated to give the crude product as a yellow solid. The crude product was recrystallized by ethyl acetate/hexane mixed solvent at 0 °C to afford the target product 4-(p-iodophenyl)butanoic acid as a light yellow solid (15.0 g, 42% yield). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ11.0 (broad single peak, 1H), 7.61 (double peaks, J = 8.4 Hz, 2H), 6.95 (double peaks, J = 8.0 Hz, 2H), 2.63 (triple peak, J = 7.6 Hz, 2H), 2.38 (triple peak, J = 7.6 Hz, 2H).
References
[1] Mendeleev Communications, 2015, vol. 25, # 2, p. 111 - 113
[2] European Journal of Organic Chemistry, 2015, vol. 2015, # 27, p. 5919 - 5924
[3] Patent: US2018/66298, 2018, A1. Location in patent: Paragraph 0172; 0173; 0174
[4] Journal of the American Chemical Society, 1943, vol. 65, p. 1273,1274
[5] Patent: US2348231, 1940,
4-(P-IODOPHENYL)BUTYRIC ACID Preparation Products And Raw materials
Raw materials
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View Lastest Price from 4-(P-IODOPHENYL)BUTYRIC ACID manufacturers
- Product
- 4-(P-IODOPHENYL)BUTYRIC ACID 27913-58-2
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 2000
- Release date
- 2025-09-10
- Product
- 4-(P-IODOPHENYL)BUTYRIC ACID 27913-58-2
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.10000000149011612kg
- Purity
- 98%
- Supply Ability
- 100kg
- Release date
- 2023-03-09
- Product
- 4-(P-IODOPHENYL)BUTYRIC ACID 27913-58-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95%
- Supply Ability
- 500KG
- Release date
- 2018-08-19