5-AMINO-2-BOC-1,2,3,4-TETRAHYDROISOQUINOLINE
- Product Name
- 5-AMINO-2-BOC-1,2,3,4-TETRAHYDROISOQUINOLINE
- CAS No.
- 201150-73-4
- Chemical Name
- 5-AMINO-2-BOC-1,2,3,4-TETRAHYDROISOQUINOLINE
- Synonyms
- CAS:201150-73-4;2-Boc-1,2,3,4-Tetrahydroisoquinolin;2-BOC-1,2,3,4-TETRAHYDROISOQUINOLIN-5-AMINE;5-AMINO-2-BOC-1,2,3,4-TETRAHYDROISOQUINOLINE;5-AMINO-N-T-BUTYLOXYCARBONYL-1,2,3,4-TETRAHYDROISOQUINOLINE;tert-butyl 5-amino-3,4-dihydro-1H-isoquinoline-2-carboxylate;5-AMINO-2-TERT-BUTOXYCARBONYL-1,2,3,4-TETRAHYDROISOQUINOLINE;TERT-BUTYL 5-AMINO-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXYLATE;tert-Butyl 5-amino-1,2,3,4-tetrahydroisoquinoline-2-carboxylate;5-Amino-2-(tert-butyloxycarbonyl)-1,2,3,4-tetrahydroisoquinoline
- CBNumber
- CB8446930
- Molecular Formula
- C14H20N2O2
- Formula Weight
- 248.32
- MOL File
- 201150-73-4.mol
5-AMINO-2-BOC-1,2,3,4-TETRAHYDROISOQUINOLINE Property
- Boiling point:
- 390.4±42.0 °C(Predicted)
- Density
- 1.145±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 4.14±0.20(Predicted)
- Appearance
- White to off-white Solid
Safety
- HazardClass
- IRRITANT
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- FA148149
- Product name
- 5-Amino-2-tert-butoxycarbonyl-1,2,3,4-tetrahydroisoquinoline
- Packaging
- 25mg
- Price
- $73
- Updated
- 2021/12/16
- Product number
- P000060233
- Product name
- tert-Butyl 5-amino-3,4-dihydroisoquinoline-2(1H)-carboxylate
- Purity
- 97%
- Packaging
- 250mg
- Price
- $78
- Updated
- 2021/12/16
- Product number
- FA148149
- Product name
- 5-Amino-2-tert-butoxycarbonyl-1,2,3,4-tetrahydroisoquinoline
- Packaging
- 50mg
- Price
- $127
- Updated
- 2021/12/16
- Product number
- 0324AB
- Product name
- tert-Butyl5-amino-3,4-dihydroisoquinoline-2(1H)-carboxylate
- Packaging
- 250mg
- Price
- $139
- Updated
- 2021/12/16
- Product number
- P000060233
- Product name
- tert-Butyl 5-amino-3,4-dihydroisoquinoline-2(1H)-carboxylate
- Purity
- 97%
- Packaging
- 1g
- Price
- $197
- Updated
- 2021/12/16
5-AMINO-2-BOC-1,2,3,4-TETRAHYDROISOQUINOLINE Chemical Properties,Usage,Production
Synthesis
115955-90-3
24424-99-5
201150-73-4
To a 1,4-dioxane (100 mL) solution of 5-amino-1,2,3,4-tetrahydroisoquinoline (3.68 g, 24.8 mmol) was added an aqueous 3 N NaOH solution (8.27 mL, 24.8 mmol). After the reaction mixture was cooled to 0°C, a solution of 1,4-dioxane (10 mL) in di-tert-butyl dicarbonate (5.42 g, 24.8 mmol) was added slowly and dropwise. After the dropwise addition, the reaction mixture was stirred at room temperature overnight. After completion of the reaction, the mixture was poured into water and extracted with ethyl acetate (2×). The organic layers were combined and washed sequentially with saturated aqueous NaHCO3 solution, water and brine. The organic layer was dried over anhydrous Na2SO4 and concentrated under reduced pressure. The residue was purified by silica gel column chromatography to afford 5.44 g (88% yield) of tert-butyl 5-amino-3,4-dihydroisoquinoline-2(1H)-carboxylate of the target compound as a white solid.
References
[1] Patent: WO2005/37214, 2005, A2. Location in patent: Page/Page column 121-122
[2] Bioorganic and Medicinal Chemistry, 2000, vol. 8, # 8, p. 2085 - 2094
[3] Patent: WO2014/160668, 2014, A1. Location in patent: Page/Page column 357
5-AMINO-2-BOC-1,2,3,4-TETRAHYDROISOQUINOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
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