3,5-DIHYDROXY-4'-BROMOSTILBENE

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3,5-DIHYDROXY-4'-BROMOSTILBENE

Product Name: 3,5-DIHYDROXY-4'-BROMOSTILBENE
CAS No.: 1224713-90-9
Chemical Name: 3,5-DIHYDROXY-4'-BROMOSTILBENE
Synonyms: 4-Bromo-Resveratrol;4'-bromo-Resveratrol;Resveratrol 4-Bromo Impurity;3,5-DIHYDROXY-4'-BROMOSTILBENE;3,5-DIHYDROXY-4'-BROMOSTILBENE;4-Bromo-Resveratrol >=98% (HPLC);(E)-5-(4-Bromostyryl)benzene-1,3-diol;5-[(E)-2-(4-bromophenyl)vinyl]resorcinol;Resveratrol Impurity 22 (4'-Bromo-resveratrol);5-[(E)-2-(4-Bromophenyl)vinyl]benzene-1,3-diol
CBNumber: CB8449214
Molecular Formula: C14H11BrO2
Formula Weight: 291.14
MOL File: Mol file

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3,5-DIHYDROXY-4'-BROMOSTILBENE Property

storage temp.: 2-8°C
solubility: DMSO: soluble20mg/mL, clear
form: powder
color: white to yellow to brown

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26
WGK Germany: 3
HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1078
Product name: 4-Bromo-Resveratrol
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $106
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML1078
Product name: 4-Bromo-Resveratrol
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $417
Updated: 2024/03/01

Cayman Chemical

Product number: 20541
Product name: 4'-bromo-Resveratrol
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 20541
Product name: 4'-bromo-Resveratrol
Purity: ≥98%
Packaging: 5mg
Price: $86
Updated: 2024/03/01

Cayman Chemical

Product number: 20541
Product name: 4'-bromo-Resveratrol
Purity: ≥98%
Packaging: 10mg
Price: $153
Updated: 2024/03/01

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3,5-DIHYDROXY-4'-BROMOSTILBENE Chemical Properties,Usage,Production

Biological Activity

4'-bromo-resveratrol is a sirt1 and sirt3 inhibitor.sirtuins are protein deacetylases regulating aging processes and many physiological functions. resveratrol activates human sirt1 and inhibits sirt3, and can mimic calorie restriction effects including lifespan extension in lower organisms.

in vitro

sirtuin modulation was studied by using 4’-bromo-resveratrol in a previous study. 4’-bromo-resveratrol inhibited sirt3 with much higher potency than resveratrol, and it also inhibited rather than activated sirt1. crystal structures of human sirt3/peptide complexes of 4’ -bromo-resveratrol identified two binding sites. an internal site caused the potent inhibitory effect. 4’-bromo-resveratrol interfered with nad+ and substrate peptide binding, and it extended its bromo-phenyl group in a unrecognized site pocket. the second binding site for 4’-bromo-resveratrol was found to be located on the surface of sirt3 and connected via two helices to peptide-binding active site loops. in sirt1, this site appeared to comprise a residue that was essential for its activation by small molecules and 4’-bromo-resveratrol therefore constituted a candidate for the long-sought allosteric sirt1 activator binding site [1].

References

[1] nguyen gt, gertz m, steegborn c. crystal structures of sirt3 complexes with 4'-bromo-resveratrol reveal binding sites and inhibition mechanism. chem biol. 2013 nov 21;20(11):1375-85.

3,5-DIHYDROXY-4'-BROMOSTILBENE Preparation Products And Raw materials

Raw materials

Preparation Products

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1224713-90-9, 3,5-DIHYDROXY-4'-BROMOSTILBENERelated Search:

trans Resveratrol 4O-b-D-Glucuronide cis Resveratrol Azo-Resveratrol trans/cis Resveratrol-D4 Oxyresveratrol CIS-TRIMETHOXY STILBENE Dihydroresveratrol trans Resveratrol 3-O-β-D-Glucuronide 3,4',5-TRIMETHOXY-TRANS-STILBENE 4'-Methoxyresveratrol Resveratrol 3,5-DIHYDROXY-4'-METHOXYSTILBENE 3-O-BETA-D-GLUCOSIDE Resveratrol-13C6 PICEATANNOL Acetyl-trans-resveratrol cis Resveratrol 3-O-b-D-Glucuronide 1-O-Levulinoyl Resveratrol Diacetate Resveratrol 3-Sulfat-4’glucuronide

3,5-DIHYDROXY-4'-BROMOSTILBENE

5-[(E)-2-(4-Bromophenyl)vinyl]benzene-1,3-diol

4-Bromo-Resveratrol

5-[(1E)-2-(4-Bromophenyl)ethenyl]-1,3-benzenediol

5-[(E)-2-(4-bromophenyl)ethenyl]benzene-1,3-diol

5-[(E)-2-(4-bromophenyl)vinyl]resorcinol

1,3-Benzenediol, 5-[(1E)-2-(4-bromophenyl)ethenyl]-

Resveratrol 4-Bromo Impurity

Resveratrol Impurity 22 (4'-Bromo-resveratrol)

4-Bromo-Resveratrol >=98% (HPLC)

(E)-5-(4-Bromostyryl)benzene-1,3-diol

melanoma cell growth,Apoptosis,Sirtuin-3,Sirtuin-1,4' bromo Resveratrol,inhibit,Inhibitor,cell cycle,Sirtuin,4′‐BR,4'bromoResveratrol,mitochondrial metabolic reprogramming,antiproliferative

4'-bromo-Resveratrol

3,5-DIHYDROXY-4'-BROMOSTILBENE

1224713-90-9