6-CHLOROMELATONIN Property

Melting point:

147-148 °C

Boiling point:

536.7±50.0 °C(Predicted)

Density 

1.272±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

alcohol: soluble

pka

15.99±0.30(Predicted)

form 

Powder

Safety

Hazard Codes 

T

Risk Statements 

60-23/24/25-36/37/38

Safety Statements 

53-26-36/37/39-45

WGK Germany 

3

RTECS 

AB5750000

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H311Toxic in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H331Toxic if inhaled

H335May cause respiratory irritation

H360May damage fertility or the unborn child

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P311Call a POISON CENTER or doctor/physician.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P322Specific measures (see …on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P361Remove/Take off immediately all contaminated clothing.

P362Take off contaminated clothing and wash before reuse.

P363Wash contaminated clothing before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

6-CHLOROMELATONIN Chemical Properties,Usage,Production

Uses

6-Chloromelatonin is a potent agonist of the melatonin receptors.

Definition

ChEBI: N-[2-(6-chloro-5-methoxy-1H-indol-3-yl)ethyl]acetamide is a member of acetamides.

Biological Activity

Potent melatonin agonist (pK i values are 9.10 and 9.77 for human recombinant MT 1 and MT 2 receptors respectively). Displays higher affinity for binding to hamster brain membrane and chicken retina than melatonin.