ChemicalBook > CAS DataBase List > 5-BROMO-7-NITRO-1H-INDAZOLE

5-BROMO-7-NITRO-1H-INDAZOLE

Product Name
5-BROMO-7-NITRO-1H-INDAZOLE
CAS No.
316810-82-9
Chemical Name
5-BROMO-7-NITRO-1H-INDAZOLE
Synonyms
5-BROMO-7-NITRO-1H-INDAZOLE;1H-Indazole, 5-bromo-7-nitro-
CBNumber
CB8464503
Molecular Formula
C7H4BrN3O2
Formula Weight
242.03
MOL File
Mol file
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5-BROMO-7-NITRO-1H-INDAZOLE Property

Melting point:
220°C
Boiling point:
420.8±25.0 °C(Predicted)
Density 
1.965±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
8.77±0.40(Predicted)
Appearance
Light yellow to yellow Solid
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Safety

Hazard Codes 
Xi
HazardClass 
IRRITANT
HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H228Flammable solid

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P403Store in a well-ventilated place.

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N-Bromosuccinimide Price

Biosynth Carbosynth
Product number
FB140325
Product name
5-Bromo-7-nitro-1H-indazole
Packaging
100mg
Price
$50
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB140325
Product name
5-Bromo-7-nitro-1H-indazole
Packaging
250mg
Price
$80
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB140325
Product name
5-Bromo-7-nitro-1H-indazole
Packaging
500mg
Price
$125
Updated
2021/12/16
AK Scientific
Product number
W5359
Product name
5-Bromo-7-nitro-1H-indazole
Packaging
250mg
Price
$131
Updated
2021/12/16
AK Scientific
Product number
W5359
Product name
5-Bromo-7-nitro-1H-indazole
Packaging
1g
Price
$150
Updated
2021/12/16
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5-BROMO-7-NITRO-1H-INDAZOLE Chemical Properties,Usage,Production

Synthesis

77811-44-0

316810-82-9

General procedure for the synthesis of 5-bromo-7-nitro-1H-indazole from 2-methyl-4-bromo-6-nitroaniline: the raw material 2-methyl-4-bromo-6-nitroaniline (1.00 g, 4.32 mmol) was dissolved in 15 mL of acetic acid. An aqueous solution (2 mL) of sodium nitrite (0.66 mg, 9.52 mmol) was added slowly at 0 °C. After addition, the reaction mixture was gradually warmed up to room temperature with continuous stirring. The progress of the reaction was monitored by thin layer chromatography (TLC) until complete conversion of the feedstock. Upon completion of the reaction, the solvent was removed by rotary evaporation followed by extraction operation. The crude product was purified by column chromatography to afford the final target compound 5-bromo-7-nitro-1H-indazole (0.5 mg, 2.07 mmol) in orange powder form in 47.7% yield.

References

[1] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2000, vol. 39, # 5, p. 339 - 345
[2] Journal of Medicinal Chemistry, 2015, vol. 58, # 9, p. 3892 - 3909
[3] Patent: CN108689937, 2018, A. Location in patent: Paragraph 0179; 0181; 0182
[4] Patent: CN108689936, 2018, A. Location in patent: Paragraph 0118; 0119; 0120; 0121

5-BROMO-7-NITRO-1H-INDAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-BROMO-7-NITRO-1H-INDAZOLE Suppliers

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View Lastest Price from 5-BROMO-7-NITRO-1H-INDAZOLE manufacturers

Shanghai Rlavie Technology Co ltd
Product
5-Bromo-7-nitro-1H-indazole 316810-82-9
Price
US $0.00-0.00/KG
Min. Order
1g
Purity
98%min
Supply Ability
100kgs/month
Release date
2021-11-23
Career Henan Chemical Co
Product
5-BROMO-7-NITRO-1H-INDAZOLE 316810-82-9
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2020-01-09