3-CYANO-2,6-DIHYDROXY-4-(TRIFLUOROMETHYL)PYRIDINE

Product Name: 3-CYANO-2,6-DIHYDROXY-4-(TRIFLUOROMETHYL)PYRIDINE
CAS No.: 3335-46-4
Chemical Name: 3-CYANO-2,6-DIHYDROXY-4-(TRIFLUOROMETHYL)PYRIDINE
Synonyms: 2,6-Dihydroxy-4-(trifluoromethyl);6-Dihydroxy-3-cyano-4-(trifluoroMethyl)pyridine;2,6-DIHYDROXY-4-(TRIFLUOROMETHYL)NICOTINONITRILE;3-CYANO-2,6-DIHYDROXY-4-(TRIFLUOROMETHYL)PYRIDINE;2,6-Dihydroxy-4-(trifluoromethyl)pyridine-3-carBonitrile;4-(trifluoroMethyl)-2,6-dihydroxypyridine-3-carbonitrile;2-hydroxy-6-oxo-4-(trifluoromethyl)-1H-pyridine-3-carbonitrile;JR-8841, 3-Cyano-2,6-dihydroxy-4-(trifluoromethyl)pyridine, 97%;3-CYANO-2,6-DIHYDROXY-4-(TRIFLUOROMETHYL)PYRIDINE ISO 9001：2015 REACH;3-Pyridinecarbonitrile, 1,2-dihydro-6-hydroxy-2-oxo-4-(trifluoromethyl)-
CBNumber: CB8465393
Molecular Formula: C7H3F3N2O2
Formula Weight: 204.11
MOL File: 3335-46-4.mol

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3-CYANO-2,6-DIHYDROXY-4-(TRIFLUOROMETHYL)PYRIDINE Property

Melting point:: 285°C
Boiling point:: 267.8±40.0 °C(Predicted)
Density: 1.63±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
pka: 2.57±0.58(Predicted)
Appearance: Off-white to light brown Solid

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Safety

Hazard Codes: Xi,T
Risk Statements: 25-36
Safety Statements: 26-45
HazardClass: IRRITANT
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: C979250
Product name: 3-Cyano-2,6-dihydroxy-4-(trifluoromethyl)pyridine
Packaging: 500mg
Price: $55
Updated: 2021/12/16

TRC

Product number: C979250
Product name: 3-Cyano-2,6-dihydroxy-4-(trifluoromethyl)pyridine
Packaging: 5g
Price: $250
Updated: 2021/12/16

Apolloscientific

Product number: PC8755
Product name: 2,6-Dihydroxy-4-(trifluoromethyl)nicotinonitrile
Packaging: 10g
Price: $264
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H37-3-X8
Product name: 2,6-Dihydroxy-4-(trifluoromethyl)nicotinonitrile
Packaging: 10g
Price: $423
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0021767
Product name: 3-CYANO-2,6-DIHYDROXY-4-(TRIFLUOROMETHYL)PYRIDINE
Purity: 95.00%
Packaging: 1G
Price: $791.18
Updated: 2021/12/16

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3-CYANO-2,6-DIHYDROXY-4-(TRIFLUOROMETHYL)PYRIDINE Chemical Properties,Usage,Production

Chemical Properties

Pale yellow solid

Uses

3-Cyano-2,6-dihydroxy-4-(trifluoromethyl)pyridine is used as a reagent in the synthesis of novel monoindolyl-4-trifluoromethylpyridines and bisindolyl-4-trifluoromethylpyridines which can be used as potential antitumor agents.

Synthesis

372-31-6

107-91-5

3335-46-4

General procedure for the synthesis of 2,6-dihydroxy-3-cyano-4-(trifluoromethyl)pyridine from ethyl trifluoroacetoacetate and cyanoacetamide: 29.8 g (0.53 mol) of potassium hydroxide was slowly added to a 250 mL four-necked flask fitted with a mechanical stirrer and a reflux condenser, followed by the addition of 100 mL of methanol, and stirred until dissolved and set aside. In another 500 mL four-necked flask equipped with a mechanical stirrer, a constant pressure dropping funnel, a drying tube and a reflux condenser, 43.4 g (0.52 mol) of cyanoacetamide and 150 mL of methanol were added and heated to reflux with mechanical stirring. After the reaction solution changed from turbid to light yellow and transparent, 100 g (0.54 mol) of ethyl trifluoroacetoacetate was added. Maintaining reflux, a preconfigured methanol solution of potassium hydroxide was added slowly and dropwise. The reaction was heated and refluxed for 24 h. The complete reaction of cyanoacetamide was confirmed by TLC monitoring. The reflux unit was changed to a distillation unit and about 3/4 of the methanol was recovered. Cold water was added to the residue and after cooling to room temperature, the pH was adjusted to 3-4 with dilute hydrochloric acid and stirring was continued for 0.5 hours. The reaction mixture was filtered and the filter cake was washed with water to give the white solid product 2,6-dihydroxy-3-cyano-4-(trifluoromethyl)pyridine. The product was dried at 80 °C to constant weight to give 84.5 g final in 80.1% yield and 98% HPLC purity.

References

[1] Patent: CN107382848, 2017, A. Location in patent: Paragraph 0034-0045

3-CYANO-2,6-DIHYDROXY-4-(TRIFLUOROMETHYL)PYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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3-CYANO-2,6-DIHYDROXY-4-(TRIFLUOROMETHYL)PYRIDINE Suppliers

China 86 India 5 United Kingdom 5 United States 13 Global 109

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View Lastest Price from 3-CYANO-2,6-DIHYDROXY-4-(TRIFLUOROMETHYL)PYRIDINE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 3-CYANO-2,6-DIHYDROXY-4-(TRIFLUOROMETHYL)PYRIDINE 3335-46-4
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-13

Career Henan Chemical Co

Product: 3-CYANO-2,6-DIHYDROXY-4-(TRIFLUOROMETHYL)PYRIDINE 3335-46-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Customized
Release date: 2020-03-05

3335-46-4, 3-CYANO-2,6-DIHYDROXY-4-(TRIFLUOROMETHYL)PYRIDINERelated Search:

4-(Trifluoromethyl)pyridine 3-Cyano-2,6-dihydroxy-4-methylpyridine 6-hydroxy-4-methyl-2-pyridone 3-CYANO-2,6-DIHYDROXY-4-(TRIFLUOROMETHYL)PYRIDINE 3-CYANO-2,6-DIHYDROXY-4-(TRIFLUOROMETHYL)PYRIDINE DIHYDRATE 2,6-Dihydroxy-3,4-dimethylpyridine 4-(TRIFLUOROMETHYL)PYRIDINE-2,6-DIOL

3-CYANO-2,6-DIHYDROXY-4-(TRIFLUOROMETHYL)PYRIDINE

2,6-DIHYDROXY-4-(TRIFLUOROMETHYL)NICOTINONITRILE

2,6-Dihydroxy-4-(trifluoromethyl)pyridine-3-carBonitrile

JR-8841, 3-Cyano-2,6-dihydroxy-4-(trifluoromethyl)pyridine, 97%

2,6-Dihydroxy-4-(trifluoromethyl)

6-Dihydroxy-3-cyano-4-(trifluoroMethyl)pyridine

4-(trifluoroMethyl)-2,6-dihydroxypyridine-3-carbonitrile

2-hydroxy-6-oxo-4-(trifluoromethyl)-1H-pyridine-3-carbonitrile

3-Pyridinecarbonitrile, 1,2-dihydro-6-hydroxy-2-oxo-4-(trifluoromethyl)-

3-CYANO-2,6-DIHYDROXY-4-(TRIFLUOROMETHYL)PYRIDINE ISO 9001：2015 REACH

3335-46-4

C7H3F3N2O2

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