ChemicalBook > CAS DataBase List > 3-CYANO-2,6-DIHYDROXY-4-(TRIFLUOROMETHYL)PYRIDINE

3-CYANO-2,6-DIHYDROXY-4-(TRIFLUOROMETHYL)PYRIDINE

Product Name: 3-CYANO-2,6-DIHYDROXY-4-(TRIFLUOROMETHYL)PYRIDINE
CAS No.: 3335-46-4
Chemical Name: 3-CYANO-2,6-DIHYDROXY-4-(TRIFLUOROMETHYL)PYRIDINE
Synonyms: 2,6-Dihydroxy-4-(trifluoromethyl);6-Dihydroxy-3-cyano-4-(trifluoroMethyl)pyridine;2,6-DIHYDROXY-4-(TRIFLUOROMETHYL)NICOTINONITRILE;3-CYANO-2,6-DIHYDROXY-4-(TRIFLUOROMETHYL)PYRIDINE;2,6-Dihydroxy-4-(trifluoromethyl)pyridine-3-carBonitrile;4-(trifluoroMethyl)-2,6-dihydroxypyridine-3-carbonitrile;2-hydroxy-6-oxo-4-(trifluoromethyl)-1H-pyridine-3-carbonitrile;JR-8841, 3-Cyano-2,6-dihydroxy-4-(trifluoromethyl)pyridine, 97%;3-CYANO-2,6-DIHYDROXY-4-(TRIFLUOROMETHYL)PYRIDINE ISO 9001：2015 REACH;3-Pyridinecarbonitrile, 1,2-dihydro-6-hydroxy-2-oxo-4-(trifluoromethyl)-
CBNumber: CB8465393
Molecular Formula: C7H3F3N2O2
Formula Weight: 204.11
MOL File: 3335-46-4.mol

Less

3-CYANO-2,6-DIHYDROXY-4-(TRIFLUOROMETHYL)PYRIDINE Property

Melting point:: 285°C
Boiling point:: 267.8±40.0 °C(Predicted)
Density: 1.63±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
pka: 2.57±0.58(Predicted)
Appearance: Off-white to light brown Solid

Less

Safety

Hazard Codes: Xi,T
Risk Statements: 25-36
Safety Statements: 26-45
HazardClass: IRRITANT
HS Code: 2933399990

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

Less

N-Bromosuccinimide Price

TRC

Product number: C979250
Product name: 3-Cyano-2,6-dihydroxy-4-(trifluoromethyl)pyridine
Packaging: 500mg
Price: $55
Updated: 2021/12/16

TRC

Product number: C979250
Product name: 3-Cyano-2,6-dihydroxy-4-(trifluoromethyl)pyridine
Packaging: 5g
Price: $250
Updated: 2021/12/16

Apolloscientific

Product number: PC8755
Product name: 2,6-Dihydroxy-4-(trifluoromethyl)nicotinonitrile
Packaging: 10g
Price: $264
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H37-3-X8
Product name: 2,6-Dihydroxy-4-(trifluoromethyl)nicotinonitrile
Packaging: 10g
Price: $423
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0021767
Product name: 3-CYANO-2,6-DIHYDROXY-4-(TRIFLUOROMETHYL)PYRIDINE
Purity: 95.00%
Packaging: 1G
Price: $791.18
Updated: 2021/12/16

Less

3-CYANO-2,6-DIHYDROXY-4-(TRIFLUOROMETHYL)PYRIDINE Chemical Properties,Usage,Production

Chemical Properties

Pale yellow solid

Uses

3-Cyano-2,6-dihydroxy-4-(trifluoromethyl)pyridine is used as a reagent in the synthesis of novel monoindolyl-4-trifluoromethylpyridines and bisindolyl-4-trifluoromethylpyridines which can be used as potential antitumor agents.

Synthesis

372-31-6

107-91-5

3335-46-4

General procedure for the synthesis of 2,6-dihydroxy-3-cyano-4-(trifluoromethyl)pyridine from ethyl trifluoroacetoacetate and cyanoacetamide: 29.8 g (0.53 mol) of potassium hydroxide was slowly added to a 250 mL four-necked flask fitted with a mechanical stirrer and a reflux condenser, followed by the addition of 100 mL of methanol, and stirred until dissolved and set aside. In another 500 mL four-necked flask equipped with a mechanical stirrer, a constant pressure dropping funnel, a drying tube and a reflux condenser, 43.4 g (0.52 mol) of cyanoacetamide and 150 mL of methanol were added and heated to reflux with mechanical stirring. After the reaction solution changed from turbid to light yellow and transparent, 100 g (0.54 mol) of ethyl trifluoroacetoacetate was added. Maintaining reflux, a preconfigured methanol solution of potassium hydroxide was added slowly and dropwise. The reaction was heated and refluxed for 24 h. The complete reaction of cyanoacetamide was confirmed by TLC monitoring. The reflux unit was changed to a distillation unit and about 3/4 of the methanol was recovered. Cold water was added to the residue and after cooling to room temperature, the pH was adjusted to 3-4 with dilute hydrochloric acid and stirring was continued for 0.5 hours. The reaction mixture was filtered and the filter cake was washed with water to give the white solid product 2,6-dihydroxy-3-cyano-4-(trifluoromethyl)pyridine. The product was dried at 80 °C to constant weight to give 84.5 g final in 80.1% yield and 98% HPLC purity.

References

[1] Patent: CN107382848, 2017, A. Location in patent: Paragraph 0034-0045

3-CYANO-2,6-DIHYDROXY-4-(TRIFLUOROMETHYL)PYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

Less

3-CYANO-2,6-DIHYDROXY-4-(TRIFLUOROMETHYL)PYRIDINE Suppliers

China 86 India 5 United Kingdom 5 United States 13 Global 109

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
Advantage: 60

Shanghai Sinch Parmaceuticals Tech. Co. Ltd.

Tel: +86-21-54098501
Fax: +86-21-54096319
Email: sales@sinch.com.cn
Country: China
ProdList: 11598
Advantage: 64

Shanghai Longsheng chemical Co.,Ltd.

Tel: 021-58099652-8005 13585536065
Fax: 021-58099609
Email: bin.wu@shlschem.com
Country: China
ProdList: 9883
Advantage: 59

Hangzhou Disynthesis Chemical Technology Co., Ltd.

Tel: +86-0571-88194596 15558156576
Fax: 0571-88199298
Email: sales@disynchem.com
Country: China
ProdList: 94
Advantage: 55

China Langchem Inc.

Tel: 0086-21-58956006
Fax: 0086-21-58956100
Country: China
ProdList: 7811
Advantage: 57

Tianjin heowns Biochemical Technology Co., Ltd.

Tel: 400 638 7771
Email: sales@heowns.com
Country: China
ProdList: 14435
Advantage: 57

Suzhou Guide Fine Material Co.Ltd.

Tel: 0512-66627360 13914021065
Fax: 0512-66627360
Email: 706938434@qq.com
Country: China
ProdList: 239
Advantage: 60

Chengdu Forest Science and Technology Development Co., Ltd.

Tel: 18030648795
Fax: 028-61777050
Email: sales@cdforestchem.com
Country: China
ProdList: 2000
Advantage: 58

Chiba Pharmaceutical Science and technology Co, Ltd.

Tel: 0531-81313138 13066006660
Fax: QQ: 3366077777
Email: chibapharm@foxmail.com
Country: China
ProdList: 3991
Advantage: 55

Shanghai civi chemical technology co.,Ltd

Tel: 86-21-34053660
Fax: 86-21-34053661
Email: sale@labgogo.com
Country: China
ProdList: 9865
Advantage: 52

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 13167063860
Fax: 021-50323701
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

Chimica Laboratories Co., Ltd

Tel: 0086-573-82585213
Fax: 0086-573-82585233
Email: bai@chimicalabs.com
Country: China
ProdList: 861
Advantage: 64

AN PharmaTech Co Ltd

Tel: 86(21)68097365
Fax: 86(21)33321566
Email: sales@anpharma.net
Country: China
ProdList: 4891
Advantage: 55

Wuhan Chemwish Technology Co.， Ltd

Tel: 027-67849912
Fax: 027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 9148
Advantage: 60

Codow Chemical Co.,Ltd.

Tel: 18620099427
Fax: +86-20-62619665
Email: amy@howeipharm.com
Country: China
ProdList: 6687
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Chengdu Huachun Technology Co., Ltd

Tel: 400-1166-196 15982826727
Fax: QQ：800101999
Email: cdhxsj@163.com
Country: China
ProdList: 14603
Advantage: 60

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Yantai ShengKailun Chemical Technology Co., Ltd.

Tel: 13356901049
Fax: QQ：1025383091
Email: 3119594100@qq.com
Country: China
ProdList: 7964
Advantage: 55

Nanijing m&m biotechnology Co. ,Ltd.

Tel: 025-87782433 18021532344
Fax: 025-87782433
Email: 1345332203@qq.com
Country: China
ProdList: 4135
Advantage: 58

Shanghai BaiShun Biological Technology Co., Ltd

Tel: 021-37581181
Fax: 021-57456066
Email: sales@chem-mall.com
Country: China
ProdList: 10330
Advantage: 58

Shanghai Zhen Li Biological Technology Co., Ltd

Tel: 021-16621358918; 18516310516
Fax: 13045646768
Email: zhenlipharma888@163.com
Country: China
ProdList: 19035
Advantage: 58

Capot Chemical Co.,Ltd.

Tel: +86-（0）57185586718; +8613336195806
Fax: +86-571-85864795
Email: sales@capot.com
Country: China
ProdList: 29735
Advantage: 60

Aikon International Limited

Tel: 025-66113011 13155353615
Fax: (7)02557626880
Email: qzhang@aikonchem.com
Country: China
ProdList: 15394
Advantage: 58

Wuhan FengyaoTonghui Chemical Products Co., Ltd.

Tel: 027-87466105 15377573527
Email: 2678564200@qq.com
Country: China
ProdList: 17987
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 400821072
Fax: 021-58955996
Email: malulu@leyan.com
Country: China
ProdList: 25000
Advantage: 58

Tianjin heowns Biochemical Technology Co., Ltd.

Tel: 400-6387771-6039 18920764717
Email: sales@heowns.com
Country: China
ProdList: 23771
Advantage: 60

Hubei Xinyuanshun Pharmaceutical Chemical Co., Ltd.

Tel: 027-51831887 15337167856
Fax: 027-51837635 QQ1165326703
Email: hubeixinyuanshun@163.com
Country: China
ProdList: 10295
Advantage: 58

3A Chemicals

Tel: 400-668-9898
Fax: 010-51582189
Email: service@3achem.com
Country: China
ProdList: 20557
Advantage: 58

Zhengzhou Acme Chemical Co., Ltd.

Tel: 0371-63315541 13323832564
Fax: QQ:3001332135
Email: 3001332135@qq.com
Country: China
ProdList: 9972
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52687
Advantage: 58

Chengdu Forest Science and Technology Development Co,. Ltd

Tel: 028-87925786 18010564218
Fax: 028-61777050
Email: vendi@cdforestchem.com
Country: China
ProdList: 1992
Advantage: 58

Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9729
Advantage: 58

Allfluoro pharmaceutical co. ltd.

Tel: +86-400-0216110 +86-15958047586
Fax: 0086-21-33275002
Email: sales@allfluoro.com
Country: China
ProdList: 11385
Advantage: 58

ANHUI WITOP BIOTECH CO., LTD

Tel: +8615255079626
Email: eric@witopchemical.com
Country: China
ProdList: 23541
Advantage: 58

Hefei TNJ Chemical Industry Co.,Ltd.

Tel: +86-0551-65418671 +8618949823763
Fax: 0551-65418697
Email: sales@tnjchem.com
Country: China
ProdList: 34563
Advantage: 58

Dayang Chem (Hangzhou) Co.,Ltd.

Tel: +86-0571-88938639 +8617705817739
Fax: +86-571-88938652，+86-571- 88492614
Email: info@dycnchem.com
Country: China
ProdList: 52846
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: +86-029-89586680 +86-18192503167
Fax: +86-29-88380327
Email: 1026@dideu.com
Country: China
ProdList: 8025
Advantage: 58

SIMAGCHEM CORP

Tel: +86-5922680277 +86-13806087780
Email: sale@simagchem.com
Country: China
ProdList: 17346
Advantage: 58

Henan Weituxi Chemical Technology Co., Ltd.

Tel: 0371-63284658 18135795563
Fax: QQ:2885349392
Email: 2885349392@qq.com
Country: China
ProdList: 9992
Advantage: 58

Hubei xin bonus chemical co. LTD

Tel: 86-13657291602
Fax: 027-59338440
Email: linda@hubeijusheng.com
Country: CHINA
ProdList: 22963
Advantage: 58

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Email: sales@accelachem.com
Country: China
ProdList: 10467
Advantage: 58

Wuhan Chemwish Technology Co., Ltd

Tel: 027-67849912
Email: sales@chemwish.com
Country: CHINA
ProdList: 10821
Advantage: 58

CONIER CHEM AND PHARMA LIMITED

Tel: +8618523575427
Email: sales@conier.com
Country: China
ProdList: 49975
Advantage: 58

Less

View Lastest Price from 3-CYANO-2,6-DIHYDROXY-4-(TRIFLUOROMETHYL)PYRIDINE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 3-CYANO-2,6-DIHYDROXY-4-(TRIFLUOROMETHYL)PYRIDINE 3335-46-4
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-13

Career Henan Chemical Co

Product: 3-CYANO-2,6-DIHYDROXY-4-(TRIFLUOROMETHYL)PYRIDINE 3335-46-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Customized
Release date: 2020-03-05

3335-46-4, 3-CYANO-2,6-DIHYDROXY-4-(TRIFLUOROMETHYL)PYRIDINERelated Search:

4-(Trifluoromethyl)pyridine 3-Cyano-2,6-dihydroxy-4-methylpyridine 6-hydroxy-4-methyl-2-pyridone 3-CYANO-2,6-DIHYDROXY-4-(TRIFLUOROMETHYL)PYRIDINE 3-CYANO-2,6-DIHYDROXY-4-(TRIFLUOROMETHYL)PYRIDINE DIHYDRATE 2,6-Dihydroxy-3,4-dimethylpyridine 4-(TRIFLUOROMETHYL)PYRIDINE-2,6-DIOL

3-CYANO-2,6-DIHYDROXY-4-(TRIFLUOROMETHYL)PYRIDINE

2,6-DIHYDROXY-4-(TRIFLUOROMETHYL)NICOTINONITRILE

2,6-Dihydroxy-4-(trifluoromethyl)pyridine-3-carBonitrile

JR-8841, 3-Cyano-2,6-dihydroxy-4-(trifluoromethyl)pyridine, 97%

2,6-Dihydroxy-4-(trifluoromethyl)

6-Dihydroxy-3-cyano-4-(trifluoroMethyl)pyridine

4-(trifluoroMethyl)-2,6-dihydroxypyridine-3-carbonitrile

2-hydroxy-6-oxo-4-(trifluoromethyl)-1H-pyridine-3-carbonitrile

3-Pyridinecarbonitrile, 1,2-dihydro-6-hydroxy-2-oxo-4-(trifluoromethyl)-

3-CYANO-2,6-DIHYDROXY-4-(TRIFLUOROMETHYL)PYRIDINE ISO 9001：2015 REACH

3335-46-4

C7H3F3N2O2

apis

alcohol|cyanide