ChemicalBook > CAS DataBase List > N-Benzoyl-2-deoxy-5-O-DMT-2',2'-difluorocytidine 3-CE phosphoramidite

N-Benzoyl-2-deoxy-5-O-DMT-2',2'-difluorocytidine 3-CE phosphoramidite

Product Name
N-Benzoyl-2-deoxy-5-O-DMT-2',2'-difluorocytidine 3-CE phosphoramidite
CAS No.
142808-44-4
Chemical Name
N-Benzoyl-2-deoxy-5-O-DMT-2',2'-difluorocytidine 3-CE phosphoramidite
Synonyms
Gemcitabine 3'-CE Phosphoramidite;Gemcitabine 3'-CE Phosphoramidite;N4-Bz-DMT-2',2'-difluoro-dC-CE-Phosphoramidite;DMTr-2',2'-diFluoro-dC(Bz)-3'-CE-Phosphoramidite;DMTr-2’,2’-difluoro-dC(Bz)-3’-CED-phosphoramidite;DMTr-2’,2’-di fluoro-dC(Bz)-3’-CED-phosphoramidite;5’-O-DMTr-2’,2’-difluoro-dC(Bz)-3’-CED-phosphoramidite;5’-O-DMTr-2’,2’-difluoro-dC(Bz)-3’-CED-phosphoramidite;N-Benzoyl-2-deoxy-5-O-DMT-2',2'-difluorocytidine 3-CE phosphoramidite;N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2',2'-difluoro-2'-deoxycytidine
CBNumber
CB84659422
Molecular Formula
C46H50F2N5O8P
Formula Weight
869.89
MOL File
142808-44-4.mol
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N-Benzoyl-2-deoxy-5-O-DMT-2',2'-difluorocytidine 3-CE phosphoramidite Property

pka
8.38±0.20(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Biosynth Carbosynth
Product number
PB158887
Product name
N4-Benzoyl-2'-deoxy-5'-O-DMT-2',2'-difluorocytidine 3'-CE phosphoramidite
Packaging
5mg
Price
$50
Updated
2021/12/16
Biosynth Carbosynth
Product number
PB158887
Product name
N4-Benzoyl-2'-deoxy-5'-O-DMT-2',2'-difluorocytidine 3'-CE phosphoramidite
Packaging
10mg
Price
$80
Updated
2021/12/16
Biosynth Carbosynth
Product number
PB158887
Product name
N4-Benzoyl-2'-deoxy-5'-O-DMT-2',2'-difluorocytidine 3'-CE phosphoramidite
Packaging
25mg
Price
$125
Updated
2021/12/16
Biosynth Carbosynth
Product number
PB158887
Product name
N4-Benzoyl-2'-deoxy-5'-O-DMT-2',2'-difluorocytidine 3'-CE phosphoramidite
Packaging
50mg
Price
$190
Updated
2021/12/16
Biosynth Carbosynth
Product number
PB158887
Product name
N4-Benzoyl-2'-deoxy-5'-O-DMT-2',2'-difluorocytidine 3'-CE phosphoramidite
Packaging
100mg
Price
$250
Updated
2021/12/16
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N-Benzoyl-2-deoxy-5-O-DMT-2',2'-difluorocytidine 3-CE phosphoramidite Chemical Properties,Usage,Production

Uses

N-Benzoyl-2-deoxy-5-O-DMT-2',2'-difluorocytidine 3-CE phosphoramidite can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.

Synthesis

1.Dissolve 5'-Dimethoxytrityl-N 4-benzoyl-2',2'-difluoro-2'-deoxycytidine (1 equiv., 0.4 mmol, 270 mg)in anhydrous acetonitrile (6 ml).
2.Add 0.5 M solution of ethylothiotetrazole (1.6 equiv., 0.65 mM, 1.3 ml) in anhydrous acetonitrile and 2-cyanoethyl-bis-(N,N'-diisopropropyl)phosphoramidite (1.43 equiv., 0.57 mmol, 0.2 ml) to the above solution.
3.Stir the reaction mixture at room temperature for 1 h to obtain product.

N-Benzoyl-2-deoxy-5-O-DMT-2',2'-difluorocytidine 3-CE phosphoramidite Preparation Products And Raw materials

Raw materials

Preparation Products

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N-Benzoyl-2-deoxy-5-O-DMT-2',2'-difluorocytidine 3-CE phosphoramidite Suppliers

China 31 United Kingdom 1 United States 3 Global 35
Carbosynth
Tel
--
Fax
--
Email
sales@carbosynth.com
Country
United Kingdom
ProdList
6005
Advantage
58

142808-44-4, N-Benzoyl-2-deoxy-5-O-DMT-2',2'-difluorocytidine 3-CE phosphoramiditeRelated Search:


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  • N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2',2'-difluoro-2'-deoxycytidine
  • 5'-O-DMT-N4-Benzoyl-2',2'-difluoro-2'-deoxycytidine 3'-CE phosphoramidite
  • N4-Benzoyl-2'-deoxy-5'-O-DMT-2',2'-difluorocytidine 3'-CE phosphoramidite
  • Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2',2'-difluoro-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
  • DMTr-2’,2’-di fluoro-dC(Bz)-3’-CED-phosphoramidite
  • N4-Benzoyl-5’-O-(4,4’-dimethoxy trityl) -2’,2’-difluoro-2’-deoxycytidine 3’-O-[(2-cyanoethyl) (N,N-diisopropyl)]-phosphoramidite
  • N4-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2',2'-difluoro-2'-deoxycytidine-3'-cyanoethyl Phosphoramidite
  • N4-Bz-DMT-2',2'-difluoro-dC-CE-Phosphoramidite
  • 5’-O-DMTr-2’,2’-difluoro-dC(Bz)-3’-CED-phosphoramidite
  • (2R,3R,5R)-5-(4-Benzamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4,4-difluorotetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
  • Gemcitabine 3'-CE Phosphoramidite
  • DMTr-2',2'-diFluoro-dC(Bz)-3'-CE-Phosphoramidite
  • N4-Benzoyl-2'-deoxy-5'-O-DMTr-2', 2'-difluorocytidine 3'-cyanoethyl phosphoramidite
  • N4-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2',2'-difluoro-2'-deoxycytidine-3'-cyanoethylPhosphoramidite
  • DMTr-2’,2’-difluoro-dC(Bz)-3’-CED-phosphoramidite
  • Gemcitabine 3'-CE Phosphoramidite
  • 5’-O-DMTr-2’,2’-difluoro-dC(Bz)-3’-CED-phosphoramidite
  • 142808-44-4
  • C46H50F2N5O8P
  • Other
  • Phosphoramidite