Adecatumumab

Product Name: Adecatumumab
CAS No.: 503605-66-1
Chemical Name: Adecatumumab
Synonyms: MT 201;Adecatumumab;Adecatumumab (anti-EpCAM);Research Grade Adecatumumab;Research Grade Adecatumumab (DHD17402)
CBNumber: CB84662613
Formula Weight: 0
MOL File: Mol file

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Adecatumumab Property

form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: ATB0023631
Product name: ADECATUMUMAB
Purity: 95.00%
Packaging: 5MG
Price: $499.84
Updated: 2021/12/16

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Adecatumumab Chemical Properties,Usage,Production

Uses

Adecatumumab (Anti-Human EPCAM Recombinant Antibody; MT201) is a full human monoclonal antibody of the IgG1 isotype, targeting human EpCAM. Adecatumumab is expressed in almost all adenocarcinomas, and its activity is not dependent of K-Ras status[1][2].

in vivo

Adecatumumab (300 μg/mouse; i.v. bolus injection; 3 times per week) inhibits tumor growth in B16/EpCAM xenograft tumor model in mice, both of human adecatumumab and mu-adecatumumab^[2].
Both human adecatumumab and mu-adecatumumab (300 μg/mouse; i.v. bolus injection; single dose) exhibit a bi-exponential curve progression of serum concentration with an early distribution phase between 0 and 10 h and a terminal elimination phase^[2].

Animal Model:	Female immunocompetent C57BL/6 mice (6-10 weeks old) with B16/EpCAM (i.v.)^[2]
Dosage:	250 μg/mouse and 600 μg/mouse for human Adecatumumab; 125 μg/mouse and 300 μg/mouse for murine Adecatumumab
Administration:	250 μg/mouse and 600 μg/mouse for human Adecatumumab; 125 μg/mouse and 300 μg/mouse for murine Adecatumumab
Result:	Both of them exhibited anti-tumor activity against B16/EpCAM cells in mice. Although human adecatumumab inhibited the size of tumor colonies mice, the number of colonies was only slightly reduced after treatment without significant difference. In contrast, mu-adecatumumab induced a highly significant reduction in the number of lung tumor colonies by >85%, and the few remaining tumor colonies were of very small size.

References

[1] Kurtz JE, et al. Adecatumumab: an anti-EpCAM monoclonal antibody, from the bench to the bedside. Expert Opin Biol Ther. 2010 Jun;10(6):951-8. DOI:10.1517/14712598.2010.482098
[2] Lutterbuese P, et al. Exchanging human Fcgamma1 with murine Fcgamma2a highly potentiates anti-tumor activity of anti-EpCAM antibody adecatumumab in a syngeneic mouse lung metastasis model. Cancer Immunol Immunother. 2007 Apr;56(4):459-68. DOI:10.1007/s00262-006-0218-7

Adecatumumab Preparation Products And Raw materials

Raw materials

Preparation Products

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Adecatumumab Suppliers

China 19 United States 1 Global 20

Shanghai YuanYe Biotechnology Co., Ltd.

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Adecatumumab (anti-EpCAM)

503605-66-1