QUINOLINE-6-CARBOHYDRAZIDE
- Product Name
- QUINOLINE-6-CARBOHYDRAZIDE
- CAS No.
- 5382-47-8
- Chemical Name
- QUINOLINE-6-CARBOHYDRAZIDE
- Synonyms
- 6QuinolCON2;6-quinolinecarbohydrazide;QUINOLINE-6-CARBOHYDRAZIDE;6-Quinolinecarbohydrazide , tech;6-Quinolinecarboxylic acid hydrazide;quinoline-6-carbohydrazide(SALTDATA: FREE)
- CBNumber
- CB8468839
- Molecular Formula
- C10H9N3O
- Formula Weight
- 187.2
- MOL File
- 5382-47-8.mol
QUINOLINE-6-CARBOHYDRAZIDE Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
Safety
- HazardClass
- IRRITANT
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- Q990095
- Product name
- Quinoline-6-carbohydrazide
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 037875
- Product name
- Quinoline-6-carbohydrazide
- Packaging
- 500mg
- Price
- $113
- Updated
- 2021/12/16
- Product number
- Y9387
- Product name
- Quinoline-6-carbohydrazide
- Packaging
- 500mg
- Price
- $202
- Updated
- 2021/12/16
- Product number
- CHM0304628
- Product name
- 6-QUINOLINE CARBOHYDRAZIDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $504.13
- Updated
- 2021/12/16
- Product number
- CM227739
- Product name
- Quinoline-6-carbohydrazide
- Purity
- 95%
- Packaging
- 5g
- Price
- $569
- Updated
- 2021/12/16
QUINOLINE-6-CARBOHYDRAZIDE Chemical Properties,Usage,Production
Synthesis
38896-30-9
5382-47-8
General procedure for the synthesis of quinoline-6-carbohydrazide from methyl 6-quinolinecarboxylate: Methyl 6-quinolinecarboxylate (0.10 mol) was dissolved in ethanol (50 mL), 99% hydrazine hydrate (0.10 mol) was added, and the mixture was refluxed for 17 hours. Upon completion of the reaction, the reaction mixture was cooled and the resulting solid was collected by filtration and washed with a small amount of cold methanol to give quinoline-6-carbohydrazide. The reaction process was monitored by thin layer chromatography (TLC) with the unfolding agent being toluene: acetone (8:2, v/v). The product was a colorless solid in 89% yield, melting point 195-197 °C. IR (KBr, cm^-1): 3376, 3291 (NH2), 1689 (C=O, amide).1H NMR (400 MHz, DMSO-d6): δ 10.34 (br s, 1H, NH), 8.89 (dd, J = 1.7, 4.1 Hz, 1H) , 8.38-8.43 (m, 2H), 8.19 (dd, J = 1.6, 8.3 Hz, 1H), 7.97 (d, J = 7.7 Hz, 1H), 7.53 (dd, J = 4.1, 8.3 Hz, 1H), 4.71 (br s, 2H, NH2).
References
[1] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 5, p. 2017 - 2029
[2] European Journal of Medicinal Chemistry, 2014, vol. 71, p. 24 - 30
[3] Journal of Medicinal Chemistry, 2013, vol. 56, # 3, p. 761 - 780
[4] Medicinal Chemistry, 2013, vol. 9, # 4, p. 596 - 607
QUINOLINE-6-CARBOHYDRAZIDE Preparation Products And Raw materials
Raw materials
Preparation Products
QUINOLINE-6-CARBOHYDRAZIDE Suppliers
- Tel
- --
- Fax
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- info@chemsworth.com
- Country
- India
- ProdList
- 6700
- Advantage
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