ChemicalBook > CAS DataBase List > CP-105,696

CP-105,696

Product Name
CP-105,696
CAS No.
158081-99-3
Chemical Name
CP-105,696
Synonyms
CP-105,696;Pfizer 105696;UNII-Z7354TW4BM;CP105696,CP 105696;CP-105,696 >=98% (HPLC);CP105696 (Pfizer 105696);CP-105696, 10 mM in DMSO;CP 105696; CP105696; CP-105696; UNII-Z7354TW4BM; PFIZER 105696;1-((3S,4R)-3-([1,1'-biphenyl]-4-ylmethyl)-4-hydroxychroman-7-yl)cyclopentanecarboxylic acid;1-((3S,4R)-3-([1,1'-biphenyl]-4-ylmethyl)-4-hydroxychroman-7-yl)cyclopentane-1-carboxylic acid
CBNumber
CB84741785
Molecular Formula
C28H28O4
Formula Weight
428.52
MOL File
158081-99-3.mol
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CP-105,696 Property

Boiling point:
651.2±55.0 °C(Predicted)
Density 
1.252±0.06 g/cm3(Predicted)
storage temp. 
room temp
solubility 
Soluble in DMSO
form 
powder
pka
4.35±0.20(Predicted)
color 
white to beige
InChIKey
KMNLXCBYBKHKSK-BKMJKUGQSA-N
SMILES
C1(C2=CC=C3C(=C2)OC[C@H](CC2=CC=C(C4=CC=CC=C4)C=C2)[C@H]3O)(C(O)=O)CCCC1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PZ0363
Product name
CP-105,696
Purity
≥98% (HPLC)
Packaging
5MG
Price
$173
Updated
2025/07/31
Sigma-Aldrich
Product number
PZ0363
Product name
CP-105,696
Purity
≥98% (HPLC)
Packaging
25MG
Price
$536
Updated
2025/07/31
ChemScene
Product number
CS-0014935
Product name
CP-105696
Purity
≥98.0%
Packaging
5mg
Price
$290
Updated
2021/12/16
Biorbyt Ltd
Product number
orb573184
Product name
CP 105696
Purity
>98%
Packaging
100mg
Price
$1431.4
Updated
2021/12/16
Biorbyt Ltd
Product number
orb573184
Product name
CP 105696
Purity
>98%
Packaging
250mg
Price
$2541.5
Updated
2021/12/16
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CP-105,696 Chemical Properties,Usage,Production

Uses

CP-105,696 has been used as a leukotriene B4 receptor (LTB4R) antagonist to study the influence of the LTB4 pathway in the pathogenesis of acute itch flares in irritant calcipotriol (MC903)+ model allergen ovalbumin (OVA) sensitized murine model of atopic dermatitis (AD)-like disease.

Biochem/physiol Actions

CP-105,696 is an orally active, potent and selective leukotriene B4 receptor (LTB4R) antagonist (IC50 against [3H]LTB4 = 5.6 nM for binding human neutrophils; IC50 = 9.7 nM & 30.3 nM, respectively using guinea pig spleen or mouse membranes) that targets LTB4R high- and low-affinity binding sites in a LTB4 non-competitive and competitive manner, respectively. CP-105,696 inhibits 5 nM LTB4-induced human neutrophils chemotaxis and CDllb upregualtion (IC50 = 5.2 nM and 430 nM, respectively) without inhibiting cyclooxygenase activity or affecting chemotaxis induced by C5a, PAF, IL-8. Oral administration is efficacious against intradermal LTB4 (100 ng/mouse), but not IL-1, injection-induced neutrophil accumulation in mice and guinea pigs (ED50 = 4.2 and 0.26 mgkg, respectively). CP-105,696 in vivo efficacy is also demonstrated in other animal models, including collagen-induced arthritis (CIA; 0.3-10 mg/kg in mice), allergic encephalomyelitis (ED50= 8.6 mg/kg; mice), and asthma (10-30 mg/kg; primate).

in vivo

At a dose of 50 mg/kg/day (28 days), B10.BR (H2k) allografts transplanted into C57Bl/6 (H2b) recipients are significantly protected, as reflected by the mean survival time versus control grafts (27±20 days [n=10] vs. 12±6 days [n=14]; P=0.0146). Using an induction protocol (day -1 to day 3), CP-105696 at 100 mg/kg/day significantly prolongs allograft survival (33±23 days [n=9]; P=0.0026), but CP-105696 at 10 mg/kg/day does not (18±16 days [n=8]; P=0.1433). Syngeneic grafts survive indefinitely (n=11). Immunohistological evaluation of allografts at rejection reveals a mononuclear cell infiltrate composed primarily of CD3+ and CD11b+ (Mac-1+) cells, which are infrequent in syngeneic grafts. Allografts from mice treated with CP-105696 at 50 or 100 mg/kg/day demonstrat a selective reduction in β2-integrin (Mac-1) expression on monocytes/macrophages, as demonstrated by CD11b staining density compared with allograft controls[2].

IC 50

LTB4: 8.42±0.26 nM (IC50)

CP-105,696 Preparation Products And Raw materials

Raw materials

Preparation Products

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CP-105,696 Suppliers

China 31 Japan 1 United States 3 Global 35
Shanghai fuxiang biotechnology co., ltd
Tel
13611719524
Email
2674347328@qq.com
Country
China
ProdList
58
Advantage
58
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51395
Advantage
80
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4769
Advantage
55
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
Advantage
62
Chemleader Biomedical Co., Limited.
Tel
021-58180488
Fax
021-58180499
Email
sales@MedChemLeader.com
Country
China
ProdList
1006
Advantage
58
Twochem Co.Ltd.
Tel
021-58111628 15800915896
Fax
QQ 3285589261
Email
sales@twochem.com
Country
China
ProdList
1788
Advantage
58
Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
Country
China
ProdList
9729
Advantage
58
Taizhou Crene Biotechnology Co. Ltd.
Tel
+86-0576-88813233 +86-13396860566
Email
sales@pharm-intermediates.com
Country
China
ProdList
1991
Advantage
58
Tianjin Kaifu Pharmaceutical Technology Co., Ltd.
Tel
18081075745
Email
chemflowtech@sina.com
Country
China
ProdList
1886
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58

158081-99-3, CP-105,696Related Search:


  • CP-105,696
  • 1-[(3S,4R)-4-hydroxy-3-[(4-phenylphenyl)methyl]-3,4-dihydro-2H-chromen-7-yl]cyclopentane-1-carboxylic acid
  • 1-((3S,4R)-3-([1,1'-biphenyl]-4-ylmethyl)-4-hydroxychroman-7-yl)cyclopentane-1-carboxylic acid
  • CP 105696; CP105696; CP-105696; UNII-Z7354TW4BM; PFIZER 105696
  • Pfizer 105696
  • UNII-Z7354TW4BM
  • Cyclopentanecarboxylic acid, 1-[(3S,4R)-3-([1,1'-biphenyl]-4-ylmethyl)-3,4-dihydro-4-hydroxy-2H-1-benzopyran-7-yl]-
  • CP-105,696 >=98% (HPLC)
  • CP105696 (Pfizer 105696)
  • CP105696,CP 105696
  • 1-((3S,4R)-3-([1,1'-biphenyl]-4-ylmethyl)-4-hydroxychroman-7-yl)cyclopentanecarboxylic acid
  • 1-[(3S,4R)-3-({[1,1'-biphenyl]-4-yl}methyl)-4-hydroxy-3,4-dihydro-2H-1-benzopyran-7-yl]cyclopentane-1-carboxylic acid
  • CP-105696, 10 mM in DMSO
  • 158081-99-3
  • API