CP-105,696

Product Name: CP-105,696
CAS No.: 158081-99-3
Chemical Name: CP-105,696
Synonyms: CP-105,696;Pfizer 105696;UNII-Z7354TW4BM;CP105696,CP 105696;CP-105,696 >=98% (HPLC);CP105696 (Pfizer 105696);CP 105696; CP105696; CP-105696; UNII-Z7354TW4BM; PFIZER 105696;1-((3S,4R)-3-([1,1'-biphenyl]-4-ylmethyl)-4-hydroxychroman-7-yl)cyclopentanecarboxylic acid;1-((3S,4R)-3-([1,1'-Biphenyl]-4-ylmethyl)-4-hydroxychroman-7-yl)cyclopentanecarboxylic acid;1-((3S,4R)-3-([1,1'-biphenyl]-4-ylmethyl)-4-hydroxychroman-7-yl)cyclopentane-1-carboxylic acid
CBNumber: CB84741785
Molecular Formula: C28H28O4
Formula Weight: 428.52
MOL File: 158081-99-3.mol

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CP-105,696 Property

Boiling point:: 651.2±55.0 °C(Predicted)
Density: 1.252±0.06 g/cm3(Predicted)
storage temp.: room temp
solubility: Soluble in DMSO
form: powder
pka: 4.35±0.20(Predicted)
color: white to beige

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PZ0363
Product name: CP-105,696
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $164
Updated: 2023/06/20

Sigma-Aldrich

Product number: PZ0363
Product name: CP-105,696
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $508
Updated: 2023/06/20

ChemScene

Product number: CS-0014935
Product name: CP-105696
Purity: ≥98.0%
Packaging: 5mg
Price: $290
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb573184
Product name: CP 105696
Purity: >98%
Packaging: 100mg
Price: $1431.4
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb573184
Product name: CP 105696
Purity: >98%
Packaging: 250mg
Price: $2541.5
Updated: 2021/12/16

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CP-105,696 Chemical Properties,Usage,Production

Uses

CP-105,696 has been used as a leukotriene B4 receptor (LTB4R) antagonist to study the influence of the LTB4 pathway in the pathogenesis of acute itch flares in irritant calcipotriol (MC903)+ model allergen ovalbumin (OVA) sensitized murine model of atopic dermatitis (AD)-like disease.

Biochem/physiol Actions

CP-105,696 is an orally active, potent and selective leukotriene B4 receptor (LTB4R) antagonist (IC50 against [3H]LTB4 = 5.6 nM for binding human neutrophils; IC50 = 9.7 nM & 30.3 nM, respectively using guinea pig spleen or mouse membranes) that targets LTB4R high- and low-affinity binding sites in a LTB4 non-competitive and competitive manner, respectively. CP-105,696 inhibits 5 nM LTB4-induced human neutrophils chemotaxis and CDllb upregualtion (IC50 = 5.2 nM and 430 nM, respectively) without inhibiting cyclooxygenase activity or affecting chemotaxis induced by C5a, PAF, IL-8. Oral administration is efficacious against intradermal LTB4 (100 ng/mouse), but not IL-1, injection-induced neutrophil accumulation in mice and guinea pigs (ED50 = 4.2 and 0.26 mgkg, respectively). CP-105,696 in vivo efficacy is also demonstrated in other animal models, including collagen-induced arthritis (CIA; 0.3-10 mg/kg in mice), allergic encephalomyelitis (ED50= 8.6 mg/kg; mice), and asthma (10-30 mg/kg; primate).

CP-105,696 Preparation Products And Raw materials

Raw materials

Preparation Products

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CP-105,696 Suppliers

China 29 Japan 1 United States 3 Global 33

Shanghai fuxiang biotechnology co., ltd

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Nanjing Chemlin Chemical Co., Ltd

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Sigma-Aldrich

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Shanghai Lollane Biological Technology Co.,Ltd.

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ShangHai Biochempartner Co.,Ltd

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Chemleader Biomedical Co., Limited.

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Taizhou Crene Biotechnology Co. Ltd.

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Tianjin Kaifu Pharmaceutical Technology Co., Ltd.

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158081-99-3, CP-105,696Related Search:

CP-105,696

1-[(3S,4R)-4-hydroxy-3-[(4-phenylphenyl)methyl]-3,4-dihydro-2H-chromen-7-yl]cyclopentane-1-carboxylic acid

1-((3S,4R)-3-([1,1'-biphenyl]-4-ylmethyl)-4-hydroxychroman-7-yl)cyclopentane-1-carboxylic acid

CP 105696; CP105696; CP-105696; UNII-Z7354TW4BM; PFIZER 105696

Pfizer 105696

UNII-Z7354TW4BM

Cyclopentanecarboxylic acid, 1-[(3S,4R)-3-([1,1'-biphenyl]-4-ylmethyl)-3,4-dihydro-4-hydroxy-2H-1-benzopyran-7-yl]-

CP-105,696 >=98% (HPLC)

CP105696 (Pfizer 105696)

CP105696,CP 105696

1-((3S,4R)-3-([1,1'-biphenyl]-4-ylmethyl)-4-hydroxychroman-7-yl)cyclopentanecarboxylic acid

1-((3S,4R)-3-([1,1'-Biphenyl]-4-ylmethyl)-4-hydroxychroman-7-yl)cyclopentanecarboxylic acid

1-((3S,4R)-3-([1,1'-Biphenyl]-4-ylmethyl)-4-hydroxychroman-7-yl)cyclopentane-1-carboxylic acid

1-[(3S,4R)-3-({[1,1'-biphenyl]-4-yl}methyl)-4-hydroxy-3,4-dihydro-2H-1-benzopyran-7-yl]cyclopentane-1-carboxylic acid

158081-99-3

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