CINCHONINE MONOHYDROCHLORIDE HYDRATE

CINCHONINE MONOHYDROCHLORIDE HYDRATE Property

Melting point:

208-218 °C(lit.)

solubility 

soluble in Ethanol

form 

powder to crystal

color 

White to Almost white

optical activity

[α]20/D +101°, c = 1 in chloroform

BRN 

5784953

Safety

Hazard Codes 

Xn

Risk Statements 

20/21/22

Safety Statements 

36/37-36

WGK Germany 

3

RTECS 

GD2962020

F 

8

HS Code 

2939.20.0050

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

CINCHONINE MONOHYDROCHLORIDE HYDRATE Chemical Properties,Usage,Production

Uses

Cinchonine ((8R,9S)-Cinchonine) monohydrochloride hydrate is a natural compound which has been effectively used as antimalarial agent. Cinchonine monohydrochloride hydrate activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells. Cinchonine monohydrochloride hydrate is also an inhibitor of human platelet aggregation. Cinchonine monohydrochloride hydrate possesses a suppressive effect on adipogenesis[1].

References

[1] Jin ZL, et, al. Cinchonine activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells. Exp Ther Med. 2018 Jun;15(6):5046-5050. DOI:10.3892/etm.2018.6005