Cinchonine

Product Name: Cinchonine
CAS No.: 118-10-5
Chemical Name: Cinchonine
Synonyms: Cinchonin;(S)-quinolin-4-yl((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methanol;D-CINCHONINE;NSC 6176;LA40221);CINCHONINE;Xin Kening;Xin Kenning;Cinchoninne;(+)-cinconine
CBNumber: CB0244972
Molecular Formula: C19H22N2O
Formula Weight: 294.39
MOL File: 118-10-5.mol

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Cinchonine Property

Melting point:: 260-263 °C
alpha: 224 º (c=0.5, alcohol)
Boiling point:: 436.16°C (rough estimate)
Density: 1.0863 (rough estimate)
vapor pressure: 0Pa at 25℃
refractive index: 223 ° (C=0.5, EtOH)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: 0.25g/l
form: Micro-Crystalline Powder
pka: 5.85, 9.92(at 25℃)
color: White to light beige
PH: 9.0 (0.25g/l, H2O, 20℃)(as aqueous solution)
optical activity: [α]23/D +228°, c = 0.5 in ethanol
Water Solubility: Insoluble
Sensitive: Light Sensitive
Merck: 14,2287
BRN: 89689
Stability:: Stable, but may be light sensitive. Incompatible with strong oxidizing agents.
InChIKey: KMPWYEUPVWOPIM-QHQSXHFQSA-N
LogP: 2.82 at 25℃
CAS DataBase Reference: 118-10-5(CAS DataBase Reference)
NIST Chemistry Reference: Cinchonine(118-10-5)
EPA Substance Registry System: Cinchonan-9-ol, (9S)- (118-10-5)

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Safety

Hazard Codes: Xn
Risk Statements: 20/22-20/21/22
Safety Statements: 26-36-36/37
RIDADR: 1544
WGK Germany: 3
RTECS: GD3500000
F: 8-34
HazardClass: 6.1(b)
PackingGroup: III
HS Code: 29339900
Toxicity: LD50 i.p. in rats: 152 mg/kg (Johnson, Poe)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHL80963
Product name: (+)-Cinchonine
Purity: phyproof? Reference Substance
Packaging: 100MG
Price: $262
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.02506
Product name: (+)-Cinchonine
Purity: for resolution of racemates for synthesis
Packaging: 25g
Price: $80
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.02506
Product name: (+)-Cinchonine
Purity: for resolution of racemates for synthesis
Packaging: 100g
Price: $237
Updated: 2024/03/01

Sigma-Aldrich

Product number: 27370
Product name: Cinchonine
Purity: crystallized, ≥98.0% (NT)
Packaging: 25g
Price: $62.9
Updated: 2024/03/01

Sigma-Aldrich

Product number: 19431
Product name: (+)-Cinchonine
Purity: analytical standard
Packaging: 50mg
Price: $443
Updated: 2022/05/15

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Cinchonine Chemical Properties,Usage,Production

Description

Cinchonine is a cinchona alkaloid generally found in the bark of Cinchona officinalis plants. It is a pseudoenantiomer that is commonly employed in malaria therapy. Cinchonine is also used as an organocatalyst in many asymmetric reactions. It is a stereoisomer and pseudo-enantiomer of cinchonidine. It is structurally similar to quinine, an antimalarial drug.

Chemical Properties

white to light yellow crystal powde

Uses

cardiotonic

Uses

Stereomeric with Cinchonidine (C441925). Antimalarial.

Uses

Cinchonine occurs in most varieties of cinchonabark (Cinchona micrantha and Rubiaceae).It is used as an antimalarial agent.

Definition

ChEBI: Cinchonan in which a hydrogen at position 9 is substituted by hydroxy (S configuration). It occurs in the bark of most varieties of Cinchona shrubs, and is frequently used for directing chirality in asymmetric synthesis.

Health Hazard

The toxic effects from high doses of cinchonineinclude tinnitus, vomiting, diarrhea, andfever. The toxic effects noted in rats were excitement, change in motor activity, andconvulsions. An intraperitoneal LD50 valuein rats is 152 mg/kg.

Flammability and Explosibility

Non flammable

Purification Methods

Crystallise cinchonine from EtOH or diethyl ether. For the N-benzylcinchoninium chloride see above entry in this section. [Rabe Justus Liebigs Ann Chem 365 366, 371 1909, Beilstein 23 III/IV 2819, 2832.]

Cinchonine Preparation Products And Raw materials

Raw materials

Preparation Products

(S)-(-)-1,2,3,4-Tetrahedro-naphthoic acid QUININE SULFATE

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Cinchonine Suppliers

Americas 1 Belgium 4 Canada 1 China 292 Europe 2 France 2 Germany 8 India 21 Japan 6 Poland 1 Slovakia 1 South Korea 1 Switzerland 3 United Kingdom 16 United States 49 Global 408

Shanghai Uteam Biotechnology Co., Ltd.

Tel: 021-36031160 13311776681
Email: 3338195766@QQ.com
Country: China
ProdList: 5175
Advantage: 55

Shanghai Biological Technology Development Co., Ltd.

Tel: 021-69955236-807 13918189704
Fax: 021-65211385
Email: chinaruji@chinaruji.com
Country: China
ProdList: 5176
Advantage: 55

Shanghai Qiao Chemical Science Co., Ltd

Tel: 021-58892003
Email: info@qiaochem.com
Country: China
ProdList: 5881
Advantage: 65

xi'an renyang Biotechnology Co., Ltd.

Tel: 13299086402
Email: renyangbiotech@163.com
Country: China
ProdList: 80
Advantage: 58

Shanxi Yuning Biotechnology Co., Ltd.

Tel: 13623677056
Email: 1639455302@qq.com
Country: China
ProdList: 285
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 021-61259108 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40240
Advantage: 62

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15848
Advantage: 69

future industrial shanghai co., ltd

Tel: 400-0066400 13621662912
Fax: 021-55660885
Email: sales@jonln.com
Country: China
ProdList: 1998
Advantage: 65

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30132
Advantage: 84

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View Lastest Price from Cinchonine manufacturers

Hebei Guanlang Biotechnology Co., Ltd.

Product: Cinchonine 118-10-5
Price: US $10.00/PCS
Min. Order: 1KG
Purity: 99%
Supply Ability: 100 mt
Release date: 2021-05-19

Hebei Duling International Trade Co. LTD

Product: Cinchonine 118-10-5
Price: US $58.00-10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20MT
Release date: 2024-05-27

Ouhuang Engineering Materials (Hubei) Co., Ltd

Product: Cinchonine 118-10-5
Price: US $15.00/kg
Min. Order: 1kg
Purity: 99.912%
Supply Ability: 10ton
Release date: 2024-04-25

118-10-5, CinchonineRelated Search:

Methanol N-Vinyl-2-pyrrolidone 4-(4-CHLORO-BENZYLOXY)-PHENYLAMINE Triethoxyvinylsilane VINYL PROPIONATE Quinine Vinyl acetate Vinylmagnesium bromide CINCHONINE HYDROCHLORIDE Cinchonidine CINCHONINE HYDROCHLORIDE CINCHONIDINE SULFATE Simvastatin ammonium salt Simvastatin Silicone rubber,methyl-vinyl Vinyl resin Vinyl ester resin CINCHONINE HEMISULFATE,CINCHONINE HEMISULFATE SALT,cinchonine sulphate,cinchonine,sulfate(2:1)(salt

(+)-cinconine

(8r,9s)-cinchonine

(9s)-cinchonan-9-o

(9S)-Cinchonan-9-ol

D-CINCHONINE

(+)-CINCHONINE

CINCHONINE

CINCHONAN-9-OL,(9S)-

Cinchonine, 98+%

Cinchonine dihydrate monohydrochloride

Cinchonine Solution [for spray]

(9S)-Cinconan-9-ol

Cinchonin

Cinchonine,99%

(+)-Cinchonine, 98+%, cont. up to 3% quinidine/dihydroquinidine and 3% quinine/dihydroquinine

Cinchonine ,98.5%

(5-Ethenyl-1-azabicyclo[2.2.2]oct-2-yl)(quinolin-4-yl)methanol

4-[(5-Ethenyl-1-azabicyclo[2.2.2]oct-2-yl)hydroxymethyl]quinoline

(S)-{5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl}(quinolin-4-yl)Methanol

Cinchonine, 99% 100GR

Cinchonine, 99% 25GR

(+)-Cinchonine, cont. up to 3% quinidine/dihydroquinidine and 3% quinine/dihydroquinine

Cinchonine, synthesis grade

NSC 6176

(+)-CINCHONINE FOR RESOLUTION OF RACEMAT

(1S)-Quinolin-4-yl((2R,4S,5R)-5-vinylquinuclidin-2-yl)Methanol

Cinchonine (Synonyms: (8R,9S)-Cinchonine

LA40221)

[5-ethenyl-4-(2-quinolinyl)-1-azabicyclo[2.2.2]octan-2-yl]methanol

Cinchonine(LA40221)

Cinchonine ((8R,9S)-Cinchonine

Xin Kenning

alpha-(5-vinyl-2-quinolyl)-2-quinuclidinemethano

alpha-4-quinolyl-5-vinyl-2-quinuclidinemethano

Cinchonine monohydrochloride dihydrate

CINCHONINE FREE BASE

CINCHONINE, CRYSTALLIZED

CINCHONINE PURE

(+)-Quinolin-4-yl(5-vinylquinuclidin-2-yl)Methanol

Cinchonine (8CI)

Cinchonine (base and/or unspecified salts)

4-Quinolyl(5-vinyl-1-azabicyclo[2.2.2]oct-2-yl)methanol

CINCHONINE:CINCHONAN-9-OL,(9S)-,

(+)-Cinchonine, 98+%, cont. up to 3% quinidine/dihydroquinidine and 3% quinine/dihydroquinidine

CINCHONINE(P)

CINCHONINE(RG)

homocinchonidine

homoquinidine

Cinchonine , 98.0%(T)

-Quinolin-4-yl(5-vinylquinuclidin-2-yl)

(S)-quinolin-4-yl((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methanol

Xin Kening

Cinchonine &gt

(S)-Quinolin-4-yl((1S,2R,4S,5S)-5-vinylquinuclidin-2-yl)methanol

Quinidine EP Impurity B

4-QUINOLYL(5-VINYL-1-AZABICYCLO[2.2.2]OCT-2-YL)MET

Cinchonine USP/EP/BP

[(5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-quinolin-4-ylmethanol