ChemicalBook > CAS DataBase List > Histrelin

Histrelin

Description Background

Product Name: Histrelin
CAS No.: 76712-82-8
Chemical Name: Histrelin
Synonyms: histrelin acetate;PYR-HIS-TRP-SER-TYR-D-HIS(BZL)-LEU-ARG-PRO-NHET;1-9-LUTEINIZING HORMONE-RELEASING FACTOR (SWINE), 6-[1-(PHENYLMETHYL)-D-HISTIDINE]-9-(N-ETHYL-L-PROLINAMIDE)-;N-[1-[[1-[[1-[[1-[[1-[[1-[[5-(diaminomethylideneamino)-1-[2-(ethylcarbamoyl)-1-pyrrolidinyl]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-[1-(phenylmethyl)-4-imidazoly;orf17070;Supprelin;RWJ-17070;HISTRELIN;Amyridine;Histreline Acetate
CBNumber: CB8480046
Molecular Formula: C66H86N18O12
Formula Weight: 1323.53
MOL File: 76712-82-8.mol

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Histrelin Property

alpha: D20 -33.9° (c = 1 in acetic acid)
Density: 1.46±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: Aqueous Acid (Slightly), DMSO (Slightly), Methanol (Slightly)
form: powder
pka: 9.82±0.15(Predicted)
Sequence: {Pyr}-His-Trp-Ser-Tyr-D-His(Bzl)-Leu-Arg-Pro-NHEt
Stability:: Hygroscopic
InChIKey: HHXHVIJIIXKSOE-HMGGNIPDNA-N

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Safety

Hazard Codes: T
Risk Statements: 60
Safety Statements: 53-22-36/37/39-45
WGK Germany: 3
RTECS: OK6370800
HS Code: 3504009000
Hazardous Substances Data: 76712-82-8(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H360May damage fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: L2761
Product name: [des-Gly10, D-His(Bzl)6]-LH-RH ethylamide
Purity: ≥97% (HPLC), powder
Packaging: 0.5mg
Price: $162
Updated: 2025/07/31

Sigma-Aldrich

Product number: L2761
Product name: [des-Gly10, D-His(Bzl)6]-LH-RH ethylamide
Purity: ≥97% (HPLC), powder
Packaging: 1mg
Price: $263.65
Updated: 2025/07/31

American Custom Chemicals Corporation

Product number: API0002921
Product name: HISTRELIN
Purity: 95.00%
Packaging: 1MG
Price: $645.9
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb372383
Product name: Histrelin Acetate
Purity: > 95%
Packaging: 1mg
Price: $691.9
Updated: 2021/12/16

Apolloscientific

Product number: BITH3026
Product name: Histrelin
Packaging: 25mg
Price: $719
Updated: 2021/12/16

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Histrelin Chemical Properties,Usage,Production

Description

Histrelin, a synthetic gonadotrophin-releasing hormone (GnRH) agonist, was introduced as a first-line therapy for the treatment of central precocious puberty. When administered over a prolonged period, it suppresses the release of gonadotrophin, inhibits ovarian and testicular steroidogenesis, and prevents sexual maturation. Superior to the traditional therapy with progestational agents, histrelin appears to have decelerating effects on skeletal maturation allowing more statural growth and significantly increased final adult height. Histrelin has also been used to treat other disorders including endometriosis, polycystic ovarian disease, uterine leiomyomas, severe premenstrual syndrome and to prevent acute intermittent porphyria.

Chemical Properties

[α]_D²⁰-33.9°(C=1, acetic acid).

Originator

Johnson & Johnson (U.S.A.)

Uses

LHRH agonist.

Uses

[des-Gly¹⁰, D-His(Bzl)⁶]-LH-RH ethylamide has been used:

for inducing Batrachoseps gravid females to oviposit
for comparing the effect of LHRH (luteinizing hormone-releasing hormone) agonists and dopamine antagonists in Lithobates pipiens
for inducing oviposition in females of Taricha granulosa and Ensatina eschscoltzii
to induce spawning in Spea hammondii adults

Definition

ChEBI: An oligopeptide comprising pyroglutamyl, histidyl, tryptophyl, seryl, tyrosyl, 1-benzyl-D-histidyl, leucyl, arginyl, and N-ethylprolinamide residues joined in sequence. It is a synthetic nonapeptide analogue of gonadotro in-releasing hormone, and is used as a subcutaneous hydrogel implant (particularly as the diacetate salt) for the treatment of prostate cancer and for the suppression of gonadal sex hormone production in children with central precocious puberty.

brand name

Supprelin (Roberts Pharmaceutical).

Biochem/physiol Actions

Glp-His-Trp-Ser-Tyr-His(Bzl)-Leu-Arg-Pro-NHEt ([des-Gly10, D-His(Bzl)6]-LH-RH) is a GnRH (gonadotropin-releasing hormone) agonist, histerelin. GnRH (Glp-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2), which is also referred as LHRH (luteinizing hormone-releasing hormone) or gonadorelin, is crucial for mammalian reproduction and is released from hypothalamic neurons. It is responsible for the secretion of gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), from the pituitary glands. Mutations in GnRH are associated with normosmic congenital hypogonadotropic hypogonadism. Histerelin is used for the treatment of central precocious puberty in children. It inhibits actions of sex steroids on the male and female reproductive organs.

Description

Histrelin has a molecular formula of C66H86N18O12, a.a. sequence of Pyr-His-Trp-Ser-Tyr-D-His(Bzl)-Leu-Arg-Pro-NHEt and having a Mw of 1323.32 Dalton.

Background

Histrelin is a hormone similar to one normally released from the hypothalamus gland in the brain. Histrelin works by decreasing the amount of estrogen and testosterone in the blood. Suppressing estrogen can cause thinning of the bones or slowing of their growth. Histrelin acetate is a potent LHRH agonist which stimulates LH and FSH release and inhibits the actions of sex steroids on the male and female reproductive tracts. After a transient increase, continuous administration results in down regulation of LH and FSH levels followed by a suppression of ovarian and testicular steroid biosynthesis. Histrelin potency in vivo and in vitro is similar to that of the D-Trp6-containing analog. Especially because of its high water solubility and greater lipophilic character, it appears promising for clinical application.

Histrelin Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Histrelin manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Histrelin Acetate 76712-82-8
Price: US $0.00/g
Min. Order: 1g
Purity: 98%min
Supply Ability: 1000g
Release date: 2023-01-12

Zhuozhou Wenxi import and Export Co., Ltd

Product: Histrelin 76712-82-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

Career Henan Chemical Co

Product: Histrelin 76712-82-8
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000KG
Release date: 2019-08-31

76712-82-8, HistrelinRelated Search:

Benzyl acetate Butyl acetate Cellulose acetate Ammonium acetate Goserelin acetate Vinyl acetate Sodium acetate Taltirelin Alarelin Acetate Ethyl acetate Magnesium acetate ACETATE LHRH (1-6) AMIDE FERTIRELIN Histamine L-Prolinamide (D-LEU7)-HISTRELIN Fertirelin acetate

N-[1-[[1-[[1-[[1-[[1-[[1-[[5-(diaminomethylideneamino)-1-[2-(ethylcarbamoyl)-1-pyrrolidinyl]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-[1-(phenylmethyl)-4-imidazoly

1-9-LUTEINIZING HORMONE-RELEASING FACTOR (SWINE), 6-[1-(PHENYLMETHYL)-D-HISTIDINE]-9-(N-ETHYL-L-PROLINAMIDE)-

Pyr-His-Trp-Ser-Tyr-D-His(Bzl)-Leu-Arg-Pro-NHEt acetate salt

5-oxo-L-pmlyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-N^<T>^-benzyl-D-histidyl-L-leucyl-L-arginyl-N-ethyl-L-pmlinamide

RWJ-17070

Supprelin

5-Oxo-L-Pro-L-His-L-Trp-L-Ser-L-Tyr-1-benzyl-D-His-L-Leu-L-Arg-L-Pro-N-ethyl-NH2

Histreline Acetate

((imbl)-d-his(sub6),pro(sub9)-net)lhrh

(n-ethyl-l-prolinamide)-10-deglycinamide-

6-(1-(phenylmethyl)-d-histidine)-9-luteinizinghormonereleasingfactor(pig

orf17070

PYR-HIS-TRP-SER-TYR-HIS(BZL)-LEU-ARG-PRO-NHET

PYR-HIS-TRP-SER-TYR-D-HIS(BZL)-LEU-ARG-PRO-NHET

PGLU-HIS-TRP-SER-TYR-D-HIS[BZL]-LEU-ARG-PRO-NHET

(HIS(BZL)6)-HISTRELIN

HISTRELIN

histrelin acetate

(DES-GLY10,HIS(BZL)6,PRO-NHET9)-GONADOTROPIN-RELEASING HORMONE

(DES-GLY10,HIS(BZL)6,PRO-NHET9)-LHRH

(DES-GLY10,HIS(BZL)6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING FACTOR

(DES-GLY10,HIS(BZL)6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING HORMONE

DES-GLY10,[D-HIS(BZL)6]-LH-RH ETHYLAMIDE

(DES-GLY10,D-HIS(BZL)6,PRO-NHET9)-GONADOTROPIN-RELEASING HORMONE

(DES-GLY10,D-HIS(BZL)6,PRO-NHET9)-LHRH

[DES-GLY10, D-HIS(BZL)6, PRO-NHET9]-LH-RH (HUMAN)

(DES-GLY10,D-HIS(BZL)6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING FACTOR

(DES-GLY10,D-HIS(BZL)6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING HORMONE

[DES-GLY10, D-HIS(BZL)6, PRO-NHET9]-LUTEINIZING HORMONE-RELEASING HORMONE (HUMAN)

Histrelin USP/EP/BP

Histrelin Acetate(net)

Amyridine

[des-Gly<sup>10</sup>, <sc>D</sc>-His(Bzl)<sup>6</sup>]-LH-RH ethylamide

76712-82-8

C66H86N18O12

Biochemicals and Reagents

Amino Acids and Peptides

BioChemical

Peptides

Releasing Factors

LH-RH

hormones

Peptide