ChemicalBook > CAS DataBase List > N/aa

N/aa

Product Name
N/aa
CAS No.
1311136-84-1
Chemical Name
N/aa
Synonyms
AUT1, 10 mM in DMSO;(R)-5-Ethyl-3-(6-(3-methoxy-4-methylphenoxy)pyridin-3-yl)imidazolidine-2,4-dione;(5R)-5-ethyl-3-[6-(3-methoxy-4-methylphenoxy)pyridin-3-yl]imidazolidine-2,4-dione;(5R)-5-Ethyl-3-[6-(3-methoxy-4-methylphenoxy)-3-pyridinyl]-2,4-imidazolidinedione;2,4-Imidazolidinedione, 5-ethyl-3-[6-(3-methoxy-4-methylphenoxy)-3-pyridinyl]-, (5R)-;(R)-5-Ethyl-3-(6-(3-methoxy-4-methylphenoxy)pyridin-3-yl)imidazolidine-2,4-dione , AUT1;Kv3.1b,corticolimbic circuits,inhibit,AUT 1,AUT1,dysfunction,Potassium Channel,recombinant human Kv3 channels,human recombinant,KcsA,schizophrenia,Inhibitor,AUT-1,Kv3.2a
CBNumber
CB84804783
Molecular Formula
C18H19N3O4
Formula Weight
341.36
MOL File
1311136-84-1.mol
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N/aa Property

storage temp. 
Store at -20°C
solubility 
DMSO:PBS (pH 7.2) (1:4):0.2(Max Conc. mg/mL);0.59(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);87.88(Max Conc. mM)
Ethanol:5.0(Max Conc. mg/mL);14.65(Max Conc. mM)
form 
A crystalline solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
28599
Product name
AUT1
Packaging
10mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
28599
Product name
AUT1
Packaging
100mg
Price
$341
Updated
2024/03/01
Cayman Chemical
Product number
28599
Product name
AUT1
Packaging
50mg
Price
$193
Updated
2024/03/01
TRC
Product number
E678890
Product name
(5R)-5-Ethyl-3-[6-(3-methoxy-4-methylphenoxy)-3-pyridinyl]-2,4-imidazolidinedione
Packaging
50mg
Price
$185
Updated
2021/12/16
TRC
Product number
E678890
Product name
(5R)-5-Ethyl-3-[6-(3-methoxy-4-methylphenoxy)-3-pyridinyl]-2,4-imidazolidinedione
Packaging
500mg
Price
$1470
Updated
2021/12/16
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N/aa Chemical Properties,Usage,Production

Description

AUT1 is a positive modulator of the voltage-gated potassium channel subtypes Kv3.1b, Kv3.2a, and Kv3.3 (EC50s = 4.7, 4.9, and 31.6 μM, respectively, in a patch-clamp assay). It is selective for Kv3.1b, Kv3.2a, and Kv3.3 over Kv1.5 and Kv7.1/minK channels but also inhibits the serotonin (5-HT) transporter, 5-HT3 receptor, and α1 subunit-containing nicotinic acetylcholine receptor (nAChR) in a panel of 26 ion channels, receptors, and transporters. AUT1 increases tetraethylammonium-induced decreases in the firing frequency and amplitude of action potentials in mouse somatosensory cortex slices when used at concentrations of 1 and 10 μM.

Uses

(5R)-5-Ethyl-3-[6-(3-methoxy-4-methylphenoxy)-3-pyridinyl]-2,4-imidazolidinedione, is a novel modulator of Kv3 potassium channels which biological studies have shown it regulates the firing of parvalbumin-positive cortical interneurons.

References

[1] MARCELO D ROSATO-SIRI. A Novel Modulator of Kv3 Potassium Channels Regulates the Firing of Parvalbumin-Positive Cortical Interneurons.[J]. Journal of Pharmacology and Experimental Therapeutics, 2015, 354 3: 251-260. DOI: 10.1124/jpet.115.225748

N/aa Preparation Products And Raw materials

Raw materials

Preparation Products

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N/aa Suppliers

China 47 United States 7 Global 54
Shanghai SuperLan Chemcial Technique Centre
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info@bocsci.com
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EnliPharma Technology Co., Ltd
Tel
0551-66399836 18955197623
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sales@enlipharma.com
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China
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Shanghai Lollane Biological Technology Co.,Ltd.
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021-52996696，15000506266 15000506266
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+86-21-52996696
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China
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Shanghai YuanYe Biotechnology Co., Ltd.
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021-61312847; 18021002903
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QQ:3008007432
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3008007409@qq.com
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China
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ShangHai Biochempartner Co.,Ltd
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177-54423994 17754423994
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QQ:2853530913
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2853530910@QQ.com
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Shanghai Rechem science Co., Ltd.
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021-31433387 15618786686
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QQ:1369748377
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sales@rechemscience.com
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Heze Development Zone chuangli Chemical Co., Ltd.
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0530-+86-530-529 6766，+86-15666160102 15666160102
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0530-529 6766
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Aikon International Limited
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025-58851090 15955137747
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(6)02557626880
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sales01@aikonchem.com
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Rhawn Reagent
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400-133-2688
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huyue@rhawn.cn
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China
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14948
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1311136-84-1, N/aaRelated Search:


  • 2,4-Imidazolidinedione, 5-ethyl-3-[6-(3-methoxy-4-methylphenoxy)-3-pyridinyl]-, (5R)-
  • (5R)-5-Ethyl-3-[6-(3-methoxy-4-methylphenoxy)-3-pyridinyl]-2,4-imidazolidinedione
  • Kv3.1b,corticolimbic circuits,inhibit,AUT 1,AUT1,dysfunction,Potassium Channel,recombinant human Kv3 channels,human recombinant,KcsA,schizophrenia,Inhibitor,AUT-1,Kv3.2a
  • (R)-5-Ethyl-3-(6-(3-methoxy-4-methylphenoxy)pyridin-3-yl)imidazolidine-2,4-dione
  • (5R)-5-ethyl-3-[6-(3-methoxy-4-methylphenoxy)pyridin-3-yl]imidazolidine-2,4-dione
  • (R)-5-Ethyl-3-(6-(3-methoxy-4-methylphenoxy)pyridin-3-yl)imidazolidine-2,4-dione , AUT1
  • AUT1, 10 mM in DMSO
  • 1311136-84-1