ChemicalBook > CAS DataBase List > 2-AMINO-3-FLUOROPHENOL

2-AMINO-3-FLUOROPHENOL

Product Name
2-AMINO-3-FLUOROPHENOL
CAS No.
53981-23-0
Chemical Name
2-AMINO-3-FLUOROPHENOL
Synonyms
2-AMINO-3-FLUOROPHENOL;2-Fluoro-6-hydroxyaniline;Phenol, 2-aMino-3-fluoro-;6-Fluoro-2-hydroxyaniline;2-AMINO-3-FLUOROPHENOL ISO 9001：2015 REACH
CBNumber
CB8480536
Molecular Formula
C6H6FNO
Formula Weight
127.12
MOL File
53981-23-0.mol
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2-AMINO-3-FLUOROPHENOL Property

Melting point:
126-127°
Boiling point:
221.9±25.0 °C(Predicted)
Density 
1.347±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
form 
solid
pka
8.76±0.10(Predicted)
color 
Light yellow to brown
InChI
InChI=1S/C6H6FNO/c7-4-2-1-3-5(9)6(4)8/h1-3,9H,8H2
InChIKey
QOZLOYKAFDTQNU-UHFFFAOYSA-N
SMILES
C1(O)=CC=CC(F)=C1N
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
22-37/38-41
Safety Statements 
26-39
RIDADR 
2512
HazardClass 
IRRITANT
PackingGroup 
Ⅲ
HS Code 
2908990000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H228Flammable solid

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P281Use personal protective equipment as required.

P308+P313IF exposed or concerned: Get medical advice/attention.

P403Store in a well-ventilated place.

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N-Bromosuccinimide Price

TRC
Product number
A609755
Product name
2-Amino-3-fluorophenol
Packaging
5g
Price
$365
Updated
2021/12/16
Matrix Scientific
Product number
041030
Product name
2-Amino-3-fluorophenol
Purity
98%
Packaging
5g
Price
$380
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA44991
Product name
2-Amino-3-fluorophenol
Packaging
2g
Price
$456
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA44991
Product name
2-Amino-3-fluorophenol
Packaging
5G
Price
$660
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0011026
Product name
2-AMINO-3-FLUOROPHENOL
Purity
95.00%
Packaging
1G
Price
$952.88
Updated
2021/12/16
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2-AMINO-3-FLUOROPHENOL Chemical Properties,Usage,Production

Uses

2-Amino-3-fluorophenol is a reagent that is used in the preparation of benzimidazole- and benzoxazole-pyrimidone selective PI3Kβ inhibitors for the treatment of phosphatase and TENsin homologue (PTEN) deficient cancers.

Synthesis

385-01-3

53981-23-0

Step 1. General procedure for the synthesis of 2-amino-3-fluorophenol from 3-fluoro-2-nitrophenol: Stannous chloride dihydrate (0.724 g, 3.18 mmol) was added to a solution of tetrahydrofuran (THF, 5.0 mL) of 3-fluoro-2-nitrophenol (0.100 g, 0.636 mmol, SynQuest), followed by water ( 5.0 mL). The reaction mixture was heated to 80 °C and maintained for 40 min. After the reaction was completed, it was cooled to room temperature and the reaction mixture was diluted with ethyl acetate and saturated sodium bicarbonate solution. The insoluble material was removed by filtration and the organic and aqueous layers were separated. The aqueous layer was extracted three times with ethyl acetate. The combined organic extracts were washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated to give the crude product 2-amino-3-fluorophenol (65 mg, 80% yield), which could be used in the subsequent reaction without further purification.LCMS (M + H)+: 128.0.

References

[1] ChemMedChem, 2017, vol. 12, # 17, p. 1436 - 1448
[2] Journal of Labelled Compounds and Radiopharmaceuticals, 2006, vol. 49, # 7, p. 623 - 634
[3] Patent: US5886044, 1999, A
[4] Patent: US5780483, 1998, A
[5] Patent: US6262113, 2001, B1

2-AMINO-3-FLUOROPHENOL Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-AMINO-3-FLUOROPHENOL manufacturers

Career Henan Chemical Co
Product
2-AMINO-3-FLUOROPHENOL 53981-23-0
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
200kgs
Release date
2020-01-10

53981-23-0, 2-AMINO-3-FLUOROPHENOLRelated Search:

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  • 6-Fluoro-2-hydroxyaniline
  • 2-AMINO-3-FLUOROPHENOL
  • Phenol, 2-aMino-3-fluoro-
  • 2-Fluoro-6-hydroxyaniline
  • 2-AMINO-3-FLUOROPHENOL ISO 9001：2015 REACH
  • 53981-23-0
  • 53891-23-0
  • Fluorine series