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(R)-(-)-α-Methylhistamine dihydrobromide

Product Name
(R)-(-)-α-Methylhistamine dihydrobromide
CAS No.
868698-49-1
Chemical Name
(R)-(-)-α-Methylhistamine dihydrobromide
Synonyms
(R)-(-)-α-Methylhistamine dihydrobromide;(αR)?-α-?Methyl-1H-?imidazole-?5-?ethanamine Hydrobromide;(R)()αMethylhistamine dihydrobromide,(R) ( ) α Methylhistamine dihydrobromide
CBNumber
CB84806424
Molecular Formula
C6H12BrN3
Formula Weight
206.09
MOL File
868698-49-1.mol
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(R)-(-)-α-Methylhistamine dihydrobromide Property

storage temp. 
Desiccate at RT
form 
White solid.
color 
Brown to reddish brown
Water Solubility 
Soluble to 100 mM in water
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
M275190
Product name
(αR)​-α-​Methyl-1H-​imidazole-​5-​ethanamineHydrobromide
Packaging
1mg
Price
$70
Updated
2021/12/16
ApexBio Technology
Product number
B5010
Product name
(R)-(-)-α-Methylhistaminedihydrobromide
Packaging
10mg
Price
$219
Updated
2021/12/16
ApexBio Technology
Product number
B5010
Product name
(R)-(-)-α-Methylhistaminedihydrobromide
Packaging
50mg
Price
$921
Updated
2021/12/16
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(R)-(-)-α-Methylhistamine dihydrobromide Chemical Properties,Usage,Production

Uses

(αR)?-α-?Methyl-1H-?imidazole-?5-?ethanamine Hydrobromide is a histamine H3 agonist and an inhibitor of histamine synthesis.

in vivo

Pretreatment with (R)-(-)-α-Methylhistamine dihydrobromide (RAMH; 10 mg/kg; i.p.; 60 min before training) reverses Propofol‐induced (25 mg/kg; i.p.; 30 min before training) memory retention[5].
(R)-(-)-α-Methylhistamine dihydrochloride (6.3 mg/kg; i.p.) significantly decreases the steady-state t-MH level in the mouse brain, whereas these compounds produced no significant changes in the HA level[3].

Animal Model:Male Sprague‐Dawley rats (10-12 week)[3]
Dosage:10 mg/kg
Administration:IP; 60 min before training
Result:Reversed propofol‐induced memory retention.

IC 50

H3 Receptor: 50.3 nM (Kd)

storage

Desiccate at RT

(R)-(-)-α-Methylhistamine dihydrobromide Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-(-)-α-Methylhistamine dihydrobromide Suppliers

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  • (R)-(-)-α-Methylhistamine dihydrobromide
  • (αR)?-α-?Methyl-1H-?imidazole-?5-?ethanamine Hydrobromide
  • (R)()αMethylhistamine dihydrobromide,(R) ( ) α Methylhistamine dihydrobromide
  • 868698-49-1