thioperamide maleate salt

Product Name: thioperamide maleate salt
CAS No.: 148440-81-7
Chemical Name: thioperamide maleate salt
Synonyms: MR-12842 maleate;N-Cyclohexyl-4-(1H-imidazol-4-yl)-1-piperidinecarbothioamide maleate salt;MR-12842, N-Cyclohexyl-4-(1H-imidazol-4-yl)-1-piperidinecarbothioamide maleate salt;1-Piperidinecarbothioamide, N-cyclohexyl-4-(1H-imidazol-4-yl)-, (2Z)-2-butenedioate (1:1);MR-12842,inhibit,Thioperamide maleate,MR 12842,MR12842,Histamine Receptor,Inhibitor,Thioperamide
CBNumber: CB91216162
Molecular Formula: C15H24N4SC4H4O4
Formula Weight: 0
MOL File: 148440-81-7.mol

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thioperamide maleate salt Property

storage temp.: desiccated under inert gas
solubility: H2O: >10mg/mL
form: solid
color: white

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T123
Product name: Thioperamide maleate salt
Purity: solid
Packaging: 10mg
Price: $78
Updated: 2024/03/01

Sigma-Aldrich

Product number: T123
Product name: Thioperamide maleate salt
Purity: solid
Packaging: 25mg
Price: $187.8
Updated: 2024/03/01

Cayman Chemical

Product number: 10011127
Product name: Thioperamide (maleate)
Purity: ≥98%
Packaging: 1mg
Price: $15
Updated: 2024/03/01

Cayman Chemical

Product number: 10011127
Product name: Thioperamide (maleate)
Purity: ≥98%
Packaging: 5mg
Price: $57
Updated: 2024/03/01

Sigma-Aldrich

Product number: T123
Product name: Thioperamide maleate salt
Purity: solid
Packaging: 100mg
Price: $950
Updated: 2024/03/01

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thioperamide maleate salt Chemical Properties,Usage,Production

Description

Thioperamide (maleate) is a selective histamine H₃ receptor antagonist that crosses the blood-brain barrier. This compound binds to rat cerebral cortical cells in vitro with a pK_i value of 8.4 and inhibits histamine binding in vivo with an ED₅₀ value of 1 mg/kg. At a dose of 5 mg/kg thioperamide (maleate) inhibits kindled seizures in rats by decreasing histamine and gamma-aminobutyric acid.

Uses

Thioperamide maleate salt was used to study the sympathetic and autonomic nerve activity in mammalian white adipose tissue.

Biochem/physiol Actions

Thioperamide is a potent and selective H3 histamine receptor antagonist that crosses the blood-brain barrier. It affects the central histaminergic system and decreases the duration of seizures and convulsions in mice. It also improves learning deficit induced by other drugs such as scopolamine.

thioperamide maleate salt Preparation Products And Raw materials

Raw materials

Preparation Products

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thioperamide maleate salt Suppliers

China 17 Switzerland 1 United States 5 Global 23

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148440-81-7, thioperamide maleate saltRelated Search:

Azelastine hydrochloride (R)-(-)-α-Methylhistamine dihydrobromide Astemizole 1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride Ketotifen fumarate 6-[2-(4-IMIDAZOLYL)ETHYLAMINO]-N-(4-TRIFLUOROMETHYLPHENYL)HEPTANECARBOXAMIDE DIMALEATE AMTHAMINE DIHYDROBROMIDE

MR-12842, N-Cyclohexyl-4-(1H-imidazol-4-yl)-1-piperidinecarbothioamide maleate salt

N-Cyclohexyl-4-(1H-imidazol-4-yl)-1-piperidinecarbothioamide maleate salt

1-Piperidinecarbothioamide, N-cyclohexyl-4-(1H-imidazol-4-yl)-, (2Z)-2-butenedioate (1:1)

MR-12842 maleate

MR-12842,inhibit,Thioperamide maleate,MR 12842,MR12842,Histamine Receptor,Inhibitor,Thioperamide

148440-81-7