ChemicalBook > CAS DataBase List > (S)-BOL-303242X)
(S)-BOL-303242X)
- Product Name
- (S)-BOL-303242X)
- CAS No.
- 887375-15-7
- Chemical Name
- (S)-BOL-303242X)
- Synonyms
- (S)-ZK-245186;(S)-Mapracorat;(S)-BOL-303242X);(Synonyms: (S)-ZK-245186;(S)-Mapracorat (Synonyms: (S)-ZK-245186;(SYNONYMS: (S)-ZK-245186; (S)-BOL-303242X);7-Benzofuranpropanol, 5-fluoro-2,3-dihydro-γ,γ-dimethyl-α-[[(2-methyl-5-quinolinyl)amino]methyl]-α-(trifluoromethyl)-, (αS)-
- CBNumber
- CB84844417
- Molecular Formula
- C25H26F4N2O2
- Formula Weight
- 462.49
- MOL File
- 887375-15-7.mol
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(S)-BOL-303242X) Property
- Boiling point:
- 602.1±55.0 °C(Predicted)
- Density
- 1.316±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: ≥ 50.6 mg/mL (109.41 mM)
- pka
- 11.75±0.29(Predicted)
- form
- Solid
- color
- Light yellow to yellow
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N-Bromosuccinimide Price
ChemScene
- Product number
- CS-0084839
- Product name
- (S)-Mapracorat
- Purity
- 99.40%
- Packaging
- 5mg
- Price
- $650
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0084839
- Product name
- (S)-Mapracorat
- Purity
- 99.40%
- Packaging
- 10mg
- Price
- $950
- Updated
- 2021/12/16
Biorbyt Ltd
- Product number
- orb573271
- Product name
- (S)-Mapracorat
- Purity
- >98%
- Packaging
- 100mg
- Price
- $1802
- Updated
- 2021/12/16
Biorbyt Ltd
- Product number
- orb573271
- Product name
- (S)-Mapracorat
- Purity
- >98%
- Packaging
- 250mg
- Price
- $3580.2
- Updated
- 2021/12/16
DC Chemicals
- Product number
- DC20017
- Product name
- (S)-Mapracorat
- Purity
- >98%
- Packaging
- 250mg
- Price
- $2400
- Updated
- 2021/12/16
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(S)-BOL-303242X) Chemical Properties,Usage,Production
Description
(S)-Mapracorat is a selective and less active glucocorticoid receptor agonist.
(S)-Mapracorat concentration dependently inhibited TNFα secretion from activated canine PBMC with IC50 value of approximately 0.2 nM.
Intradermal injection of compound 48/80 (50 μg in 50 μL saline) resulted in a clear wheal and flare reaction over the 60 min observation period. Topical pre-treatment with (S)-Mapracorat (0.1%) leads to significant reduction in the wheal and flare responses compared to vehicle (acetone) treated areas.
References
[1]. BÄumer W , et al. The selective glucocorticoid receptor agonist mapracorat displays a favourable safety-efficacy ratio for the topical treatment of inflammatory skin diseases in dogs. Vet Dermatol. 2017 Feb; 28(1):46-e11.
(S)-BOL-303242X) Preparation Products And Raw materials
Raw materials
Preparation Products
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(S)-BOL-303242X) Suppliers
- Tel
- +1-781-999-5354 +1-00000000000
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32080
- Advantage
- 58