diABZI STING agonist-1 Tautomerism

Product Name: diABZI STING agonist-1 Tautomerism
CAS No.: 2138498-18-5
Chemical Name: diABZI STING agonist-1 Tautomerism
Synonyms: Tautomerism;diABZI STING agonist (Compound 3);diABZI STING agonist-1 Tautomerism;diABZI STING agonist 1 (compound 3);diABZI STING agonist (Compound 3) ，S8796;(E)-1-((E)-4-((E)-5-Carbamoyl-2-((1-ethyl-3-methyl-1H-pyrazole-5-carbonyl)imino)-7-(3-morpholinopropoxy)-2,3-dihydro-1H-benzo[d]imidazol-1-yl)but-2-en-1-yl)-2-((1-ethyl-3-methyl-1H-pyrazole-5-carbonyl)imino)-7-methoxy-2,3-dihydro-1H-benzo[d]imidazole-5-carboxamide;1H-Benzimidazole-5-carboxamide, 1-[(2E)-4-[(2E)-5-(aminocarbonyl)-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]imino]-2,3-dihydro-7-methoxy-1H-benzimidazol-1-yl]-2-buten-1-yl]-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]imino]-2,3-dihydro-7-[3-(4-morpholinyl)propoxy]-, (2E)-
CBNumber: CB84844710
Molecular Formula: C42H51N13O7
Formula Weight: 849.94
MOL File: 2138498-18-5.mol

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diABZI STING agonist-1 Tautomerism Property

Density: 1.44±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Solid
pka: 11.87±0.43(Predicted)
color: White to light yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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diABZI STING agonist-1 Tautomerism Chemical Properties,Usage,Production

Chemical Properties

diABZI STING agonist-1 Tautomerism is a potent non-nucleoside STING agonist with great potential for the treatment of human cancers.

Uses

diABZI STING agonist-1 tautomerism is a tautomerism of diABZI STING agonist-1 (HY-112921) (compound 3). diABZI STING agonist-1 tautomerism is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively[1].

in vitro

diABZI STING agonist-1 (Tautomerism) is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively. At a concentration of 1 μM, it demonstrates high selectivity against more than 350 kinases tested.

in vivo

diABZI STING agonist-1 (Tautomerism) (subcutaneous injection; 2.5 mg/kg) induces STING-dependent activation of type-I interferon and pro-inflammatory cytokines in vivo.

References

[1] Ramanjulu JM, et al. Design of amidobenzimidazole STING receptor agonists with systemic activity. Nature. 2018 Nov 7. DOI:10.1038/s41586-018-0705-y

diABZI STING agonist-1 Tautomerism Preparation Products And Raw materials

Raw materials

Preparation Products

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diABZI STING agonist-1 Tautomerism Suppliers

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2138498-18-5, diABZI STING agonist-1 TautomerismRelated Search:

diABZI STING agonist-1 Tautomerism

1H-Benzimidazole-5-carboxamide, 1-[(2E)-4-[(2E)-5-(aminocarbonyl)-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]imino]-2,3-dihydro-7-methoxy-1H-benzimidazol-1-yl]-2-buten-1-yl]-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]imino]-2,3-dihydro-7-[3-(4-morpholinyl)propoxy]-, (2E)-

diABZI STING agonist 1 (compound 3)

diABZI STING agonist (Compound 3)

Tautomerism

(E)-1-((E)-4-((E)-5-Carbamoyl-2-((1-ethyl-3-methyl-1H-pyrazole-5-carbonyl)imino)-7-(3-morpholinopropoxy)-2,3-dihydro-1H-benzo[d]imidazol-1-yl)but-2-en-1-yl)-2-((1-ethyl-3-methyl-1H-pyrazole-5-carbonyl)imino)-7-methoxy-2,3-dihydro-1H-benzo[d]imidazole-5-carboxamide

diABZI STING agonist (Compound 3) ，S8796

2138498-18-5