6-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-6-oxohexanoic acid

Product Name: 6-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-6-oxohexanoic acid
CAS No.: 2172819-74-6
Chemical Name: 6-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-6-oxohexanoic acid
Synonyms: VH032-C3-COOH;VH 032-linker 5;(S,R,S)-AHPC-C4-COOH;VH 032 amide-alkylC4-acid;(S,R. S)-AHPC-pentanoic-acid;L-Prolinamide, N-(5-carboxy-1-oxopentyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-;6-[[(S)-1-[(2S,4R)-4-Hydroxy-2-[[4-(4-methyl-5-thiazolyl)benzyl]carbamoyl]-1-pyrrolidinyl]-3,3-dimethyl-1-oxo-2-butyl]amino]-6-oxohexanoic Acid;6-(((R)-1-((2R,4S)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-6-oxohexanoic acid;6-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-6-oxohexanoic acid;5-{[(2S)-1-[(2S,4R)-4-hydroxy-2-({[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}carbamoyl)pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamoyl}pentanoic acid
CBNumber: CB84902854
Molecular Formula: C28H38N4O6S
Formula Weight: 558.69
MOL File: 2172819-74-6.mol

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6-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-6-oxohexanoic acid Property

Boiling point:: 878.5±65.0 °C(Predicted)
Density: 1.272±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO, DMF
pka: 4.70±0.10(Predicted)
form: Solid
color: white to light yellow

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Safety

HS Code: 2934100090

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 6680
Product name: VH032amide-alkylC4-acid
Purity: ≥95%(HPLC)
Packaging: 25
Price: $212
Updated: 2021/12/16

BroadPharm

Product number: BP-24508
Product name: (S,R.S)-AHPC-pentanoic-acid
Purity: 98%
Packaging: 100mg
Price: $540
Updated: 2021/12/16

BroadPharm

Product number: BP-24508
Product name: (S,R.S)-AHPC-pentanoic-acid
Purity: 98%
Packaging: 250mg
Price: $980
Updated: 2021/12/16

BroadPharm

Product number: BP-24508
Product name: (S,R.S)-AHPC-pentanoic-acid
Purity: 98%
Packaging: 500mg
Price: $1800
Updated: 2021/12/16

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6-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-6-oxohexanoic acid Chemical Properties,Usage,Production

Description

(S, R, S)-AHPC-pentanoic-acid is a PROTAC linker that incorporate an E3 ligase ligand with a linker to empower PROTAC drug research & discovery. It can react with amine containing molecules.

storage

Store at -20°C

6-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-6-oxohexanoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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6-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-6-oxohexanoic acid Suppliers

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Daicel Chiral Technologies (China)CO.,LTD

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2172819-74-6, 6-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-6-oxohexanoic acidRelated Search:

6-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-6-oxohexanoic acid

VH 032-linker 5

(S,R. S)-AHPC-pentanoic-acid

VH 032 amide-alkylC4-acid

L-Prolinamide, N-(5-carboxy-1-oxopentyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-

6-[[(S)-1-[(2S,4R)-4-Hydroxy-2-[[4-(4-methyl-5-thiazolyl)benzyl]carbamoyl]-1-pyrrolidinyl]-3,3-dimethyl-1-oxo-2-butyl]amino]-6-oxohexanoic Acid

(S,R,S)-AHPC-C4-COOH

VH032-C3-COOH

6-(((R)-1-((2R,4S)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-6-oxohexanoic acid

5-{[(2S)-1-[(2S,4R)-4-hydroxy-2-({[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}carbamoyl)pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamoyl}pentanoic acid

2172819-74-6