ChemicalBook > CAS DataBase List > O-Desmethylvenlafaxine

O-Desmethylvenlafaxine

Product Name
O-Desmethylvenlafaxine
CAS No.
93413-62-8
Chemical Name
O-Desmethylvenlafaxine
Synonyms
DVS 233;Wy-45233;desvenlafaxine;Desvenlafaxine Base;Effexor Impurity 36;Desmethylvenlafaxine;O-desMethylvenlafaxin;O-Desmethylvenlafaxine;Venlafxine-O-Desmethyl;Venlafaxine Impurity 36
CBNumber
CB8496834
Molecular Formula
C16H25NO2
Formula Weight
263.38
MOL File
93413-62-8.mol
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O-Desmethylvenlafaxine Property

Melting point:
208-213°C
Boiling point:
403.8±25.0 °C(Predicted)
Density 
1.115±0.06 g/cm3(Predicted)
Flash point:
9℃
storage temp. 
2-8°C
solubility 
insoluble in EtOH; ≥13.2 mg/mL in DMSO; ≥2.45 mg/mL in EtOH
pka
10.04±0.26(Predicted)
form 
Solid
color 
White to off-white
InChIKey
KYYIDSXMWOZKMP-UHFFFAOYSA-N
LogP
0.33 at 25℃ and pH6
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Safety

Hazard Codes 
F,T,Xi
Risk Statements 
11-23/24/25-39/23/24/25-36
Safety Statements 
7-16-36/37-45-26
RIDADR 
UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany 
3
RTECS 
GV8872620
HS Code 
29225090
Hazardous Substances Data
93413-62-8(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
V-045
Product name
O-Desmethylvenlafaxine solution
Purity
1.0?mg/mL in methanol, certified reference material, Cerilliant?
Packaging
1mL
Price
$428
Updated
2024/03/01
Sigma-Aldrich
Product number
V-007
Product name
O-Desmethylvenlafaxine solution
Purity
100?μg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant?
Packaging
1mL
Price
$95.5
Updated
2024/03/01
TCI Chemical
Product number
D5598
Product name
O-Desmethylvenlafaxine
Packaging
1G
Price
$111
Updated
2024/03/01
TCI Chemical
Product number
D5598
Product name
O-Desmethylvenlafaxine
Packaging
5G
Price
$334
Updated
2024/03/01
Cayman Chemical
Product number
9001881
Product name
(±)-O-Desmethyl Venlafaxine
Purity
≥98%
Packaging
5mg
Price
$72
Updated
2024/03/01
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O-Desmethylvenlafaxine Chemical Properties,Usage,Production

Description

Desvenlafaxine is a new member of the SNRI class of antidepressants. It is marketed as an extended release tablet for once-daily oral treatment of MDD in adult patients. Desvenlafaxine (O-desmethylvenlafaxine) is the major active metabolite of the previously marketed antidepressant venlafaxine (Effexor). Similar to venlafaxine, desvenlafaxine is a more potent inhibitor of serotonin and norepinephrine reuptake (IC50＝47 and 531 nM, respectively) than that of dopamine (62% inhibition at 100 mM) in in vitro studies. It does not have significant in vitro affinity for other neurotransmitter reporters such as a1-adrenergic, H1-histaminergic, or muscarine-cholinergic receptors. Desvenlafaxine is marketed as a racemic mixture. Specific pharmacological properties of the enantiomers of desvenlafaxine have not been reported.

Chemical Properties

White Solid

Originator

Wyeth (United States)

Uses

A metabolite of Venlafaxine, a selective serotonin noradrenaline reuptake inhibitor. Used as an antidepressant

Uses

A metabolite of Venlafaxine (V120000), a selective serotonin noradrenaline reuptake inhibitor (SNRI). Used as an antidepressant.

Uses

a metabolite of Venlafaxine .;Labeled Venlafaxine, intended for use as an internal standard for the quantification of Venlafaxine by GC- or LC-mass spectrometry.

Definition

ChEBI: A tertiary amino compound that is N,N-dimethylethanamine substituted at position 1 by a 1-hydroxycyclohexyl and 4-hydroxyphenyl group. It is a metabolite of the drug venlafaxine.

brand name

Pristiq

General Description

An analytical reference standard applicable for use as starting material in calibrators or controls for a variety of LC/MS or GC/MS applications such as urine drug testing, forensic analysis, or clinical toxicology. Also known as desvenlafaxine, O-desmethylvenlafaxine is an SNRI antidepressant marketed under the trade name Pristiq? for the treatment of depression. O-desmethylvenlafaxine is also a major urinary metabolite of venlafaxine, an SNRI antidepressant sold as Effexor? or Efexor and used to treat major depressive disorder, generalized anxiety disorder, and other anxiety disorders associated with depression.

Synthesis

Desvenlafaxine is chemically derived from 4-benzyloxyphenylacetic acid, by first converting to the acid chloride with oxalyl chloride and then condensing with dimethylamine to produce the corresponding N,N-dimethyl amide. Deprotonation of the amide with butyllithium, followed by condensation with cyclohexanone gives a b-hydroxyamide intermediate, which is reduced with alane, and debenzylated by using palladium on carbon and 1,4-cyclohexadiene to produce desvenlafaxine.

O-Desmethylvenlafaxine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from O-Desmethylvenlafaxine manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
O-Desmethylvenlafaxine 93413-62-8
Price
US $0.00-0.00/KG
Min. Order
5mg
Purity
99% HPLC
Supply Ability
2000tons
Release date
2019-12-30
Career Henan Chemical Co
Product
O-Desmethylvenlafaxine 93413-62-8
Price
US $2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2018-12-24

93413-62-8, O-DesmethylvenlafaxineRelated Search:

Phenol Phenol Red Ethylparaben Venlafaxine Venlafaxine hydrochloride 1-Hydroxyethylidene-1,1-diphosphonic acid Ethyl acetate HYDROXYAPATITE TYPE I 4-Aminophenol Ethyl maltol Hydroxyethyl Cellulose Cyclohexanone Nonylphenol Phenylacetone Cyclohexanol TRANS-4-ETHYLCYCLOHEXANOL Desvenlafaxine succinate R-(-)-O-DESMETHYLVENLAFAXINE

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