HEMICHOLINIUM-3

Product Name: HEMICHOLINIUM-3
CAS No.: 312-45-8
Chemical Name: HEMICHOLINIUM-3
Synonyms: hc-3;Dibromide;hemicholine;hemicholiniumbromide;hemicholinium-3bromide;hemicholiniumdibromide;hemicholinium-3dibromide;Hemicholinium 3, 10 mM in DMSO;2,2'-(4,4'-biphenylene)bis(2-hydroxy-4,4-dimethylmorpholinium) dibromide;2,2’-(4,4’-biphenylylene)bis(2-hydroxy-4,4-dimethyl-morpholiniudibromide
CBNumber: CB8497048
Molecular Formula: C24H34N2O4.2Br
Formula Weight: 574.351
MOL File: 312-45-8.mol

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HEMICHOLINIUM-3 Property

Melting point:: 180°; mp 226- 228° (dec)
storage temp.: Store at -20°C
solubility: ethanol: 1.3 mg/mL
form: solid
color: white
Water Solubility: Water : 33.33 mg/mL (58.03 mM; Need ultrasonic)
Merck: 13,4660
BRN: 5704458
EPA Substance Registry System: Morpholinium, 2,2'-[1,1'-biphenyl]-4,4'-diylbis[2-hydroxy-4,4-dimethyl-, dibromide (312-45-8)

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Safety

Hazard Codes: T
Risk Statements: 23/24/25-36/37/38
Safety Statements: 26-36/37/39-45
RIDADR: UN 2811 6.1/PG 2
WGK Germany: 3
RTECS: QF2450000
HazardClass: 6.1(b)
PackingGroup: III
Toxicity: LD50 i.p. in female mice: 0.048-0.082 mg/kg (DiAugustine, Haarstad)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: H108
Product name: Hemicholinium-3
Purity: solid, ≥95% (HPLC)
Packaging: 100mg
Price: $97.4
Updated: 2025/07/31

Sigma-Aldrich

Product number: H108
Product name: Hemicholinium-3
Purity: solid, ≥95% (HPLC)
Packaging: 500mg
Price: $326.2
Updated: 2025/07/31

TRC

Product number: H245658
Product name: Hemicholinium-3
Packaging: 10mg
Price: $80
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: INB0004498
Product name: HEMICHOLINIUM-3
Purity: 95.00%
Packaging: 100MG
Price: $597.77
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: INB0004498
Product name: HEMICHOLINIUM-3
Purity: 95.00%
Packaging: 500MG
Price: $725.22
Updated: 2021/12/16

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HEMICHOLINIUM-3 Chemical Properties,Usage,Production

Uses

Acetylcholine stores depletor

Uses

Hemicholinium-3 has been used in the preparation of Krebs-HC-3 buffer to study its effects on choline uptake and choline acetyltransferase activity in differentiated human neuroblastoma (SK-N-SH) cells.

Uses

Research tool as cholinergic probe, to deplete acetylcholine stores.

Biochem/physiol Actions

Hemicholinium-3 plays a role in blocking the neuronal choline uptake thereby inhibiting acetylcholine synthesis in the brain.

in vivo

Hemicholinium-3 impairs spatial learning. Hemicholinium-3 (2.5, 5.0 μg/rat/ICV; 1 h before training) dose dependently impairs spatial learning^[5].

HEMICHOLINIUM-3 Preparation Products And Raw materials

Raw materials

Preparation Products

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HEMICHOLINIUM-3 Suppliers

China 31 Germany 1 India 1 Switzerland 1 United Kingdom 1 United States 4 Global 39

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312-45-8, HEMICHOLINIUM-3Related Search:

4,4'-Bis(hydroxymethyl)biphenyl 2-Methylmorpholine 4-Biphenylmethanol 4-Ethylbiphenyl 2-(4-BIPHENYL)ETHYLAMINE 4,4'-Dimethylbiphenyl 4-Methylphenethylamine 1-(4-Methylphenyl)ethanol DL-ALPHA-(METHYLAMINOMETHYL)BENZYL ALCOHOL N-Methyldiethanolamine 2-(BENZYLOXY)-ETHYLAMINE 4,4'-Bis(methoxymethyl)-1,1'-biphenyl 1-(4-BIPHENYLYL)ETHANOL CHOLINE BROMIDE N,N-Dimethylphenethylamine BIPHENYLENE 4,4'-DIETHYLBIPHENYL 2-PHENYLMORPHOLINE

2,2’-(1,1’-biphenyl)-4,4’-diylbis(2-hydroxy-4,4-dimethyl-morpholinium)dibrom

2,2’-(4,4’-biphenylylene)bis(2-hydroxy-4,4-dimethyl-morpholiniudibromide

hc-3

hemicholine

hemicholinium-3bromide

hemicholinium-3dibromide

hemicholiniumbromide

hemicholiniumdibromide

2,2'-(4,4'-biphenylene)bis(2-hydroxy-4,4-dimethylmorpholinium) dibromide

2-[4-[4-(2-hydroxy-4,4-dimethyl-morpholin-4-ium-2-yl)phenyl]phenyl]-4,4-dimethyl-morpholin-4-ium-2-ol dibromide

2-[4-[4-(2-hydroxy-4,4-dimethylmorpholin-4-ium-2-yl)phenyl]phenyl]-4,4-dimethylmorpholin-4-ium-2-ol dibromide

Dibromide

HACU,Choline,receptor,system,Hemicholinium dibromide,Inhibitor,transporter,ACh,Nicotinic,Hemicholinium 3,Hemicholinium3,inhibit,nervous,Enteric,neuromuscular,acetylcholine,Cholinesterase (ChE)

2,2'-([1,1'-Biphenyl]-4,4'-diyl)bis(2-hydroxy-4,4-dimethylmorpholin-4-ium) bromide

Hemicholinium 3, 10 mM in DMSO

2,2'-([1,1'-Biphenyl]-4,4'-diyl)bis(2-hydroxy-4,4-dimethylmorpholin-4-ium) bromide

312-45-8

C24H34N2O42Br

Br2C24H34N2O4

C24H34Br2N2O4