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HEMICHOLINIUM-3

Product Name
HEMICHOLINIUM-3
CAS No.
312-45-8
Chemical Name
HEMICHOLINIUM-3
Synonyms
hc-3;Dibromide;hemicholine;hemicholiniumbromide;hemicholinium-3bromide;hemicholiniumdibromide;hemicholinium-3dibromide;2,2'-(4,4'-biphenylene)bis(2-hydroxy-4,4-dimethylmorpholinium) dibromide;2,2’-(4,4’-biphenylylene)bis(2-hydroxy-4,4-dimethyl-morpholiniudibromide;2,2’-(1,1’-biphenyl)-4,4’-diylbis(2-hydroxy-4,4-dimethyl-morpholinium)dibrom
CBNumber
CB8497048
Molecular Formula
C24H34N2O4.2Br
Formula Weight
574.351
MOL File
312-45-8.mol
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HEMICHOLINIUM-3 Property

Melting point:
180°; mp 226- 228° (dec)
storage temp. 
Store at -20°C
solubility 
ethanol: 1.3 mg/mL
form 
solid
color 
white
Water Solubility 
Water : 33.33 mg/mL (58.03 mM; Need ultrasonic)
Merck 
13,4660
BRN 
5704458
EPA Substance Registry System
Morpholinium, 2,2'-[1,1'-biphenyl]-4,4'-diylbis[2-hydroxy-4,4-dimethyl-, dibromide (312-45-8)
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Safety

Hazard Codes 
T
Risk Statements 
23/24/25-36/37/38
Safety Statements 
26-36/37/39-45
RIDADR 
UN 2811 6.1/PG 2
WGK Germany 
3
RTECS 
QF2450000
HazardClass 
6.1(b)
PackingGroup 
III
Toxicity
LD50 i.p. in female mice: 0.048-0.082 mg/kg (DiAugustine, Haarstad)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
H108
Product name
Hemicholinium-3
Purity
solid, ≥95% (HPLC)
Packaging
100mg
Price
$90.3
Updated
2024/03/01
Sigma-Aldrich
Product number
H108
Product name
Hemicholinium-3
Purity
solid, ≥95% (HPLC)
Packaging
500mg
Price
$452
Updated
2024/03/01
TRC
Product number
H245658
Product name
Hemicholinium-3
Packaging
10mg
Price
$80
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
INB0004498
Product name
HEMICHOLINIUM-3
Purity
95.00%
Packaging
10MG
Price
$280.35
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
INB0004498
Product name
HEMICHOLINIUM-3
Purity
95.00%
Packaging
100MG
Price
$597.77
Updated
2021/12/16
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HEMICHOLINIUM-3 Chemical Properties,Usage,Production

Uses

Acetylcholine stores depletor

Uses

Hemicholinium-3 has been used in the preparation of Krebs-HC-3 buffer to study its effects on choline uptake and choline acetyltransferase activity in differentiated human neuroblastoma (SK-N-SH) cells.

Uses

Research tool as cholinergic probe, to deplete acetylcholine stores.

Biochem/physiol Actions

Hemicholinium-3 plays a role in blocking the neuronal choline uptake thereby inhibiting acetylcholine synthesis in the brain.

HEMICHOLINIUM-3 Preparation Products And Raw materials

Raw materials

Preparation Products

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HEMICHOLINIUM-3 Suppliers

China 21 Germany 1 India 1 Switzerland 1 United Kingdom 1 United States 4 Global 29
SIGMA-RBI
Tel
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Fax
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Country
Switzerland
ProdList
6896
Advantage
91

312-45-8, HEMICHOLINIUM-3Related Search:

4,4'-Bis(hydroxymethyl)biphenyl 2-Methylmorpholine 4-Biphenylmethanol 4-Ethylbiphenyl 2-(4-BIPHENYL)ETHYLAMINE 4,4'-Dimethylbiphenyl 4-Methylphenethylamine 1-(4-Methylphenyl)ethanol DL-ALPHA-(METHYLAMINOMETHYL)BENZYL ALCOHOL N-Methyldiethanolamine 2-(BENZYLOXY)-ETHYLAMINE 4,4'-Bis(methoxymethyl)-1,1'-biphenyl 1-(4-BIPHENYLYL)ETHANOL CHOLINE BROMIDE N,N-Dimethylphenethylamine BIPHENYLENE 4,4'-DIETHYLBIPHENYL 2-PHENYLMORPHOLINE

  • 2,2’-(1,1’-biphenyl)-4,4’-diylbis(2-hydroxy-4,4-dimethyl-morpholinium)dibrom
  • 2,2’-(4,4’-biphenylylene)bis(2-hydroxy-4,4-dimethyl-morpholiniudibromide
  • hc-3
  • hemicholine
  • hemicholinium-3bromide
  • hemicholinium-3dibromide
  • hemicholiniumbromide
  • hemicholiniumdibromide
  • 2,2'-(4,4'-biphenylene)bis(2-hydroxy-4,4-dimethylmorpholinium) dibromide
  • 2-[4-[4-(2-hydroxy-4,4-dimethyl-morpholin-4-ium-2-yl)phenyl]phenyl]-4,4-dimethyl-morpholin-4-ium-2-ol dibromide
  • 2-[4-[4-(2-hydroxy-4,4-dimethylmorpholin-4-ium-2-yl)phenyl]phenyl]-4,4-dimethylmorpholin-4-ium-2-ol dibromide
  • Dibromide
  • HACU,Choline,receptor,system,Hemicholinium dibromide,Inhibitor,transporter,ACh,Nicotinic,Hemicholinium 3,Hemicholinium3,inhibit,nervous,Enteric,neuromuscular,acetylcholine,Cholinesterase (ChE)
  • 2,2'-([1,1'-Biphenyl]-4,4'-diyl)bis(2-hydroxy-4,4-dimethylmorpholin-4-ium) bromide
  • 312-45-8
  • C24H34N2O42Br
  • Br2C24H34N2O4
  • C24H34Br2N2O4