MRS 1523
- Product Name
- MRS 1523
- CAS No.
- 212329-37-8
- Chemical Name
- MRS 1523
- Synonyms
- MRS 1523 >98% (HPLC);UUSHFEVEROROSP-UHFFFAOYSA-N;3-propyl-6-ethyl-5-[(ethylthio)carbonyl]-2 phenyl-4-propyl-3-pyridine carboxylate;3-Pyridinecarboxylic acid, 6-ethyl-5-[(ethylthio)carbonyl]-2-phenyl-4-propyl-, propyl ester
- CBNumber
- CB8497073
- Molecular Formula
- C23H29NO3S
- Formula Weight
- 399.55
- MOL File
- 212329-37-8.mol
MRS 1523 Property
- Boiling point:
- 551.3±50.0 °C(Predicted)
- Density
- 1.100±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: >10 mg/mL
- form
- oil
- pka
- 1.44±0.28(Predicted)
- color
- colorless to light brown
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H319Causes serious eye irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313IF eye irritation persists: Get medical advice/attention.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- M1809
- Product name
- MRS 1523
- Purity
- >98% (HPLC)
- Packaging
- 5mg
- Price
- $309
- Updated
- 2024/03/01
- Product number
- M1809
- Product name
- MRS 1523
- Purity
- >98% (HPLC)
- Packaging
- 25mg
- Price
- $1230
- Updated
- 2024/03/01
- Product number
- 17128
- Product name
- MRS 1523
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $56
- Updated
- 2024/03/01
- Product number
- 17128
- Product name
- MRS 1523
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $188
- Updated
- 2024/03/01
- Product number
- 17128
- Product name
- MRS 1523
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $348
- Updated
- 2024/03/01
MRS 1523 Chemical Properties,Usage,Production
Description
MRS1523 is a selective adenosine A3 receptor antagonist (Kis = 18.9 and 113 nM for human and rat A3 receptors, respectively, versus Kis = 15.6 and 2.05 μM for rat A1 and A2A receptors, respectively). As activation of the A3 receptor is linked to several second messenger systems for signaling pathways involving inflammatory, asthmatic, and ischemic responses, this selective antagonist may be useful in characterizing the various functions of the receptor.
Uses
MRS 1523 is a selective A3 adenosine receptor (A3AR) antagonist in human and rat.
Biochem/physiol Actions
MRS 1523 is a selective?adenosine A3 receptor antagonist in the rat.
in vitro
mrs1523 reversed the increase in mrna expression in b16-f10 melanoma cells. also, mrs1523 antagonized the modulation in the expression level of the proteins, which indicated that adenosine a3r mediated the responses [1].
in vivo
c57bl/6j, male mice, inoculated b16-f10 melanoma cells, were administered mrs1523 at a dose of 100 μg/kg orally twice daily for 15 days. mrs1523 counteracted the activity of ib-meca which is an adenosine a3r agonist. in addition, it was demonstrated that the response was adenosine a3r mediated. the modulation of up-regulation of gsk-3β expression level was neutralized by mrs1523, further suggesting the specificity of the response [1].
References
[1]. madi, l., rosenberg-haggen, b., nyska, a., & korenstein, r. enhancing pigmentation via activation of a3 adenosine receptors in b16 melanoma cells and in human skin explants. experimental dermatology. 2012; 22(1): 74-77.
MRS 1523 Preparation Products And Raw materials
Raw materials
Preparation Products
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