A-331440 L-TARTARIC ACID SALT
- Product Name
- A-331440 L-TARTARIC ACID SALT
- CAS No.
- 392338-13-5
- Chemical Name
- A-331440 L-TARTARIC ACID SALT
- Synonyms
- A 331440;A331440 free base;A-331440 L-tartrate hydrate;A-331440 L-TARTARIC ACID SALT;A-331440 L-tartrate hydrate;4-[4-[3-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]propoxy]phenyl]benzonitrile;(R)-4'-(3-(3-(diMethylaMino)pyrrolidin-1-yl)propoxy)biphenyl-4-carbonitrile;[1,1'-Biphenyl]-4-carbonitrile, 4'-[3-[(3R)-3-(dimethylamino)-1-pyrrolidinyl]propoxy]-;4′-[3-[3(R)-Dimethylamino-1-pyrrolidinyl]propoxy]-[1,1-biphenyl]-4′-carbonitrile L-tartrate hydrate
- CBNumber
- CB8497851
- Molecular Formula
- C22H27N3O
- Formula Weight
- 349.47
- MOL File
- 392338-13-5.mol
A-331440 L-TARTARIC ACID SALT Property
- storage temp.
- 2-8°C
- solubility
- H2O: insoluble
- form
- solid
- color
- white to off-white
- Water Solubility
- H2O: ≥10mg/mL
Safety
- Safety Statements
- 22-24/25
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- A7730
- Product name
- A-331440 dihydrochloride
- Purity
- ≥98% (HPLC), solid
- Packaging
- 5mg
- Price
- $193
- Updated
- 2024/03/01
- Product number
- A3104
- Product name
- A-331440 L-tartrate hydrate
- Purity
- ≥98% (HPLC), solid
- Packaging
- 25mg
- Price
- $604
- Updated
- 2024/03/01
- Product number
- A7730
- Product name
- A-331440 dihydrochloride
- Purity
- ≥98% (HPLC), solid
- Packaging
- 25mg
- Price
- $564
- Updated
- 2024/03/01
- Product number
- 4697
- Product name
- A-331440 dihydrochloride
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $702
- Updated
- 2021/12/16
- Product number
- 254466
- Product name
- A 331440 dihydrochloride
- Packaging
- 10mg
- Price
- $480
- Updated
- 2021/12/16
A-331440 L-TARTARIC ACID SALT Chemical Properties,Usage,Production
Biological Activity
Histamine affects homeostatic mechanisms, including food and water consumption, by acting on central nervous system (CNS) receptors. Presynaptic histamine H3 receptors regulate release of histamine and other neurotransmitters, and histamine H3 receptor antagonists enhance neurotransmitter release. A-331440 [4μ-[3-(3(R)-(dimethylamino)-pyrrolidin-1-yl)-propoxy]-biphenyl-4-carbonitrile] is a histamine H3 receptor antagonist which binds potently and selectively to both human and r at histamine H3 receptors (Ki<=25 nM). Mice were stabilized on a high-f at diet (45 kcal % lard) prior to 28-day oral b.i.d. dosing for measurement of obesity-related parameters. A-331440 administered at 0.5 mg/kg had no significant effect on weight, whereas 5 mg/kg decreased weight comparably to dexfenfluramine (10 mg/kg). A-331440 administered at 15 mg/kg reduced weight to a level comparable to mice on the low-f at diet. The two higher doses reduced body f at and the highest dose also normalized an insulin tolerance test. These data show th at the histamine H3 receptor antagonist, A-331440, has potential as an antiobesity agent.
A-331440 L-TARTARIC ACID SALT Preparation Products And Raw materials
Raw materials
Preparation Products
A-331440 L-TARTARIC ACID SALT Suppliers
- Tel
- 15002134094
- marketing@targetmol.cn
- Country
- China
- ProdList
- 19699
- Advantage
- 58
- Tel
- (+86) 21 2033 8288
- sigmaname@qq.com
- Country
- CHINA
- ProdList
- 292362
- Advantage
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