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A-331440 L-TARTARIC ACID SALT

Product Name
A-331440 L-TARTARIC ACID SALT
CAS No.
392338-13-5
Chemical Name
A-331440 L-TARTARIC ACID SALT
Synonyms
A 331440;A331440 free base;A-331440 L-tartrate hydrate;A-331440 L-TARTARIC ACID SALT;A-331440 L-tartrate hydrate;4-[4-[3-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]propoxy]phenyl]benzonitrile;(R)-4'-(3-(3-(diMethylaMino)pyrrolidin-1-yl)propoxy)biphenyl-4-carbonitrile;[1,1'-Biphenyl]-4-carbonitrile, 4'-[3-[(3R)-3-(dimethylamino)-1-pyrrolidinyl]propoxy]-;4′-[3-[3(R)-Dimethylamino-1-pyrrolidinyl]propoxy]-[1,1-biphenyl]-4′-carbonitrile L-tartrate hydrate
CBNumber
CB8497851
Molecular Formula
C22H27N3O
Formula Weight
349.47
MOL File
392338-13-5.mol
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A-331440 L-TARTARIC ACID SALT Property

storage temp. 
2-8°C
solubility 
H2O: insoluble
form 
solid
color 
white to off-white
Water Solubility 
H2O: ≥10mg/mL
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A7730
Product name
A-331440 dihydrochloride
Purity
≥98% (HPLC), solid
Packaging
5mg
Price
$193
Updated
2024/03/01
Sigma-Aldrich
Product number
A3104
Product name
A-331440 L-tartrate hydrate
Purity
≥98% (HPLC), solid
Packaging
25mg
Price
$604
Updated
2024/03/01
Sigma-Aldrich
Product number
A7730
Product name
A-331440 dihydrochloride
Purity
≥98% (HPLC), solid
Packaging
25mg
Price
$564
Updated
2024/03/01
Tocris
Product number
4697
Product name
A-331440 dihydrochloride
Purity
≥98%(HPLC)
Packaging
50
Price
$702
Updated
2021/12/16
Usbiological
Product number
254466
Product name
A 331440 dihydrochloride
Packaging
10mg
Price
$480
Updated
2021/12/16
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A-331440 L-TARTARIC ACID SALT Chemical Properties,Usage,Production

Biological Activity

Histamine affects homeostatic mechanisms, including food and water consumption, by acting on central nervous system (CNS) receptors. Presynaptic histamine H3 receptors regulate release of histamine and other neurotransmitters, and histamine H3 receptor antagonists enhance neurotransmitter release. A-331440 [4μ-[3-(3(R)-(dimethylamino)-pyrrolidin-1-yl)-propoxy]-biphenyl-4-carbonitrile] is a histamine H3 receptor antagonist which binds potently and selectively to both human and r at histamine H3 receptors (Ki<=25 nM). Mice were stabilized on a high-f at diet (45 kcal % lard) prior to 28-day oral b.i.d. dosing for measurement of obesity-related parameters. A-331440 administered at 0.5 mg/kg had no significant effect on weight, whereas 5 mg/kg decreased weight comparably to dexfenfluramine (10 mg/kg). A-331440 administered at 15 mg/kg reduced weight to a level comparable to mice on the low-f at diet. The two higher doses reduced body f at and the highest dose also normalized an insulin tolerance test. These data show th at the histamine H3 receptor antagonist, A-331440, has potential as an antiobesity agent.

A-331440 L-TARTARIC ACID SALT Preparation Products And Raw materials

Raw materials

Preparation Products

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A-331440 L-TARTARIC ACID SALT Suppliers

China 2 Switzerland 1 United States 3 Global 6
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Switzerland
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392338-13-5, A-331440 L-TARTARIC ACID SALTRelated Search:


  • A-331440 L-TARTARIC ACID SALT
  • (R)-4'-(3-(3-(diMethylaMino)pyrrolidin-1-yl)propoxy)biphenyl-4-carbonitrile
  • A 331440
  • 4′-[3-[3(R)-Dimethylamino-1-pyrrolidinyl]propoxy]-[1,1-biphenyl]-4′-carbonitrile L-tartrate hydrate
  • A-331440 L-tartrate hydrate
  • 4-[4-[3-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]propoxy]phenyl]benzonitrile
  • A331440 free base
  • [1,1'-Biphenyl]-4-carbonitrile, 4'-[3-[(3R)-3-(dimethylamino)-1-pyrrolidinyl]propoxy]-
  • A-331440 <sc>L</sc>-tartrate hydrate
  • 392338-13-5