DEACETYLANISOMYCIN FROM STREPTOMYCES*GRISEOLUS

Product Name: DEACETYLANISOMYCIN FROM STREPTOMYCES*GRISEOLUS
CAS No.: 27958-06-1
Chemical Name: DEACETYLANISOMYCIN FROM STREPTOMYCES*GRISEOLUS
Synonyms: SA 3097D1;deacetylanisomycin;DEACETYLANISOMYCIN FROM STREPTOMYCES*GRISEOLUS;3,4-Pyrrolidinediol, 2-[(4-methoxyphenyl)methyl]-, (2R,3S,4S)-
CBNumber: CB8498030
Molecular Formula: C12H17NO3
Formula Weight: 223.27
MOL File: 27958-06-1.mol

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DEACETYLANISOMYCIN FROM STREPTOMYCES*GRISEOLUS Property

Melting point:: 176-179°
alpha: D25 -20.0° (methanol)
Boiling point:: 390.7±37.0 °C(Predicted)
Density: 1.233±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Methanol: soluble
form: A solid
pka: 9.2(at 25℃)

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 28067
Product name: Deacetylanisomycin
Packaging: 5mg
Price: $250
Updated: 2024/03/01

Cayman Chemical

Product number: 28067
Product name: Deacetylanisomycin
Packaging: 25mg
Price: $750
Updated: 2024/03/01

TRC

Product number: D198978
Product name: Deacetylanisomycin
Packaging: 10mg
Price: $415
Updated: 2021/12/16

Usbiological

Product number: 257253
Product name: Deacetylanisomycin
Packaging: 2mg
Price: $426
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0010102
Product name: DEACETYLANISOMYCIN
Purity: 95.00%
Packaging: 5MG
Price: $497.07
Updated: 2021/12/16

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DEACETYLANISOMYCIN FROM STREPTOMYCES*GRISEOLUS Chemical Properties,Usage,Production

Description

Deacetylanisomycin is a derivative of the protein and DNA synthesis inhibitor anisomycin with antimalarial and anticancer activity. It inhibits the growth of the P. falciparum strains K1 and T9-96 in vitro (IC₅₀s = 40.29 and 33.57 μM, respectively). Deacetylanisomycin is cytotoxic to LU99 lung carcinoma and MCF-7 breast cancer cells (IC₅₀s = 23 and 34 μM, respectively). It has been used as a negative control for assessment of protein synthesis inhibitor activity in molluscan neurons.

Uses

Agricultural fungicide.

Uses

Deacetylanisomycin is the core structure of a family of dihydroxypyrrolidines produced by several species of Streptomyces. Anisomycin esters are potent inhibitors of protein synthesis. While considered inactive, deacetylanisomycin is a potent growth regulator in plants and its underlying pharmacology is poorly researched. This is all the more significant as anisomycin undergoes facile hydrolysis to deacetylanisomycin in polar solvents in vitro, and in vivo.

Uses

Deacetylanisomycin is a potent inhibitor of protein synthesis.

References

[1] Y HOSOYA. Anisomycin and new congeners active against human tumor cell lines.[J]. Journal of Antibiotics, 1993, 46 8: 1300-1302. DOI: 10.7164/antibiotics.46.1300
[2] D L ALKON. Inhibition of protein synthesis prolongs Ca2+-mediated reduction of K+ currents in molluscan neurons.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1987, 84 19: 6948-6952. DOI: 10.1073/pnas.84.19.6948

DEACETYLANISOMYCIN FROM STREPTOMYCES*GRISEOLUS Preparation Products And Raw materials

Raw materials

Preparation Products

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DEACETYLANISOMYCIN FROM STREPTOMYCES*GRISEOLUS Suppliers

China 21 India 1 Switzerland 1 United Kingdom 2 United States 5 Global 30

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27958-06-1, DEACETYLANISOMYCIN FROM STREPTOMYCES*GRISEOLUSRelated Search:

Cephalosporin

SA 3097D1

deacetylanisomycin

DEACETYLANISOMYCIN FROM STREPTOMYCES*GRISEOLUS

3,4-Pyrrolidinediol, 2-[(4-methoxyphenyl)methyl]-, (2R,3S,4S)-

27958-06-1