GANAXOLONE

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Product Name: GANAXOLONE
CAS No.: 38398-32-2
Chemical Name: GANAXOLONE
Synonyms: Fampridine Impurity 80;5α-PREGNAN-3β-METHYL-3α-;5α-PREGNAN-3β-METHYL-3α-OL-20-ONE;3α-hydroxy-3β-methyl-5α-pregnan-20-one;3α-hydroxy-3β-methyl-5α-pregnan-20-one;(3α,5α)-3-Hydroxy-3-methylpregnan-20-one;(3α,5α)-3-Hydroxy-3-methyl-pregnan-20-one;Pregnan-20-one, 3-hydroxy-3-methyl-, (3α,5α)-;1-((3R,5S,8R,9S,10S,13S,14S,17S)-3-Hydroxy-3,10,13-trimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethanone;1-[(3R,5S,8R,9S,10S,13S,14S,17S)-3-hydroxy-3,10,13-trimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]ethanone
CBNumber: CB8498146
Molecular Formula: C22H36O2
Formula Weight: 332.52
MOL File: 38398-32-2.mol

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GANAXOLONE Property

Melting point:: 190-192°
alpha: D +103°
Boiling point:: 434.8±18.0 °C(Predicted)
Density: 1.036±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: ~4.2 mg/mL
form: solid
pka: 15.18±0.70(Predicted)
color: white

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
RTECS: TU4384700

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: G7795
Product name: Ganaxolone
Purity: solid
Packaging: 5mg
Price: $196
Updated: 2024/03/01

Sigma-Aldrich

Product number: G7795
Product name: Ganaxolone
Purity: solid
Packaging: 25mg
Price: $677
Updated: 2024/03/01

Cayman Chemical

Product number: 20919
Product name: Ganaxolone
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 20919
Product name: Ganaxolone
Purity: ≥98%
Packaging: 5mg
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 20919
Product name: Ganaxolone
Purity: ≥98%
Packaging: 10mg
Price: $153
Updated: 2024/03/01

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GANAXOLONE Chemical Properties,Usage,Production

Description

Ganaxolone is a 3β-methylated synthetic analog of the neurosteroid allopregnanolone that allosterically enhances GABA_A receptor current. At nanomolar concentrations, it can potentiate GABA-evoked currents at GABA_A receptor complexes containing α₁, α₂, α₃, β₂, and γ_2L subunits expressed in Xenopus oocytes. Ganaxolone has been shown to have a broad range of antiseizure activity in animal epilepsy models and human clinical trials.

Uses

Treatment of epilepsy and migraine.

Uses

Ganaxolone, is synthetic neuroactive steroid, which possess sedative, anxiolytic, and anticonvulsant properties. It is also a potent and selective positive allosteric modulator of GABAA receptors. It is also shown to be used for the treatment of epilepsy.

Definition

ChEBI: Ganaxolone is a corticosteroid hormone.

Biological Activity

Potent positive allosteric modulator of GABA A receptors. Enhances GABA-evoked chloride currents in Xenopus oocytes expressing GABA A receptors (EC 50 values are 94, 122 and 213 nM for α 2 β 1 γ 2 L , α 3 β 1 γ 2 L and α 1 β 1 γ 2 L receptors respectively). Exerts anticonvulsive effects in a broad range of animal seizure models.

Biochem/physiol Actions

Ganaxolone (3alpha-hydroxy-3beta-methyl-5alpha-pregnane-20-one) is a positive allosteric modulator of the GABAA receptor subtype; synthetic analog of the endogenous neurosteroid allopregnanolone; effective against chemically induced seizures in rats and mice. Ganaxolone is an orally active analog of allopregnanolone that is not converted to the hormonally active 3-keto form. The enhanced anticonvulsant potency of ganaxolone after neurosteroid withdrawal supports the use of ganaxolone as a specific treatment for perimenstrual catamenial epilepsy.

storage

+4°C

GANAXOLONE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from GANAXOLONE manufacturers

Career Henan Chemical Co

Product: GANAXOLONE 38398-32-2
Price: US $0.01/KG
Min. Order: 1KG
Purity: 98%; 99%
Supply Ability: 500g;1kg； 25kg
Release date: 2020-01-09

38398-32-2, GANAXOLONERelated Search:

Sofalcone GANAXOLONE

3α-hydroxy-3β-methyl-5α-pregnan-20-one

(3α,5α)-3-Hydroxy-3-methyl-pregnan-20-one

1-((3R,5S,8R,9S,10S,13S,14S,17S)-3-Hydroxy-3,10,13-trimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethanone

(3α,5α)-3-Hydroxy-3-methylpregnan-20-one

1-[(3R,5S,8R,9S,10S,13S,14S,17S)-3-hydroxy-3,10,13-trimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]ethanone

Pregnan-20-one, 3-hydroxy-3-methyl-, (3α,5α)-

Fampridine Impurity 80

5α-PREGNAN-3β-METHYL-3α-OL-20-ONE

1-[(Chemicalbook3R,5S,8R,9S,10S,13S,14S,17S)-3-hydroxy-3,10,13-trimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]ethanone

3α-hydroxy-3β-methyl-5α-pregnan-20-one

5α-PREGNAN-3β-METHYL-3α-

38398-32-2