GANAXOLONE

ChemicalBook > CAS DataBase List > GANAXOLONE

Product Name: GANAXOLONE
CAS No.: 38398-32-2
Chemical Name: GANAXOLONE
Synonyms: Fampridine Impurity 80;5α-PREGNAN-3β-METHYL-3α-;Noradrenaline Impurity 69;5α-PREGNAN-3β-METHYL-3α-OL-20-ONE;3α-hydroxy-3β-methyl-5α-pregnan-20-one;3α-hydroxy-3β-methyl-5α-pregnan-20-one;(3α,5α)-3-Hydroxy-3-methylpregnan-20-one;(3α,5α)-3-Hydroxy-3-methyl-pregnan-20-one;Pregnan-20-one, 3-hydroxy-3-methyl-, (3α,5α)-;1-((3R,5S,8R,9S,10S,13S,14S,17S)-3-Hydroxy-3,10,13-trimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethanone
CBNumber: CB8498146
Molecular Formula: C22H36O2
Formula Weight: 332.52
MOL File: 38398-32-2.mol

Less

GANAXOLONE Property

Melting point:: 190-192°
alpha: D +103°
Boiling point:: 434.8±18.0 °C(Predicted)
Density: 1.036±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: ~4.2 mg/mL
form: solid
pka: 15.18±0.70(Predicted)
color: white

Less

Safety

Safety Statements: 22-24/25
WGK Germany: 3
RTECS: TU4384700

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: G7795
Product name: Ganaxolone
Purity: solid
Packaging: 5mg
Price: $196
Updated: 2024/03/01

Sigma-Aldrich

Product number: G7795
Product name: Ganaxolone
Purity: solid
Packaging: 25mg
Price: $677
Updated: 2024/03/01

Cayman Chemical

Product number: 20919
Product name: Ganaxolone
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 20919
Product name: Ganaxolone
Purity: ≥98%
Packaging: 5mg
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 20919
Product name: Ganaxolone
Purity: ≥98%
Packaging: 10mg
Price: $153
Updated: 2024/03/01

Less

GANAXOLONE Chemical Properties,Usage,Production

Description

Ganaxolone is a 3β-methylated synthetic analog of the neurosteroid allopregnanolone that allosterically enhances GABA_A receptor current. At nanomolar concentrations, it can potentiate GABA-evoked currents at GABA_A receptor complexes containing α₁, α₂, α₃, β₂, and γ_2L subunits expressed in Xenopus oocytes. Ganaxolone has been shown to have a broad range of antiseizure activity in animal epilepsy models and human clinical trials.

Uses

Treatment of epilepsy and migraine.

Uses

Ganaxolone, is synthetic neuroactive steroid, which possess sedative, anxiolytic, and anticonvulsant properties. It is also a potent and selective positive allosteric modulator of GABAA receptors. It is also shown to be used for the treatment of epilepsy.

Definition

ChEBI: Ganaxolone is a corticosteroid hormone.

Biological Activity

Potent positive allosteric modulator of GABA A receptors. Enhances GABA-evoked chloride currents in Xenopus oocytes expressing GABA A receptors (EC 50 values are 94, 122 and 213 nM for α 2 β 1 γ 2 L , α 3 β 1 γ 2 L and α 1 β 1 γ 2 L receptors respectively). Exerts anticonvulsive effects in a broad range of animal seizure models.

Biochem/physiol Actions

Ganaxolone (3alpha-hydroxy-3beta-methyl-5alpha-pregnane-20-one) is a positive allosteric modulator of the GABAA receptor subtype; synthetic analog of the endogenous neurosteroid allopregnanolone; effective against chemically induced seizures in rats and mice. Ganaxolone is an orally active analog of allopregnanolone that is not converted to the hormonally active 3-keto form. The enhanced anticonvulsant potency of ganaxolone after neurosteroid withdrawal supports the use of ganaxolone as a specific treatment for perimenstrual catamenial epilepsy.

storage

+4°C

GANAXOLONE Preparation Products And Raw materials

Raw materials

Preparation Products

Less

GANAXOLONE Suppliers

China 49 Germany 1 India 4 Japan 1 South Korea 1 Switzerland 1 United Kingdom 4 United States 10 Global 71

Hunan Well Medicine Synthesis Technology Co., Ltd

Tel: 13574065797
Email: 3877753494@qq.com
Country: China
ProdList: 33
Advantage: 58

Bayee Biotech (Anqing) Co., Ltd.

Tel: 0556-5032306 18917961636
Fax: +86-556-5032307
Email: wtx@bayeebio.com
Country: China
ProdList: 262
Advantage: 61

Taizhou Nanfeng Pharmaceutical Research Institute

Tel: 18616377689
Email: nanfengdrug@163.com
Country: China
ProdList: 20010
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 94657
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15839
Advantage: 69

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14103
Advantage: 59

WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.

Tel: 17702719238 17702719238
Email: sales@sun-shinechem.com
Country: China
ProdList: 985
Advantage: 64

Nanjing Sunlida Biological Technology Co., Ltd.

Tel: 025-57798810
Fax: 025-57019371
Email: sales@sunlidabio.com
Country: China
ProdList: 3239
Advantage: 55

Hangzhou J&H Chemical Co., Ltd.

Tel: 0571-+86-571-87396432
Fax: 0571-87396431
Email: sales@jhechem.com
Country: China
ProdList: 11578
Advantage: 59

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51456
Advantage: 80

Pharmacodia (Beijing) Co.,Ltd

Tel: +86-400-851-9921
Fax: +86-10-82826195
Email: sales@pharmacodia.com
Country: China
ProdList: 2317
Advantage: 55

Chengdu HuaNa Chemicals Co., Ltd.

Tel: 028-86612776; 13699069380
Fax: -
Email: 515238037@qq.com
Country: China
ProdList: 965
Advantage: 55

ShangHai Biochempartner Co.,Ltd

Tel: 17754423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8011
Advantage: 62

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Shanghai Biopharmaleader Co., Ltd.

Tel: +86 18721201413
Fax: +86 (21) 5775-8967
Email: sales@biopharmaleader.com
Country: China
ProdList: 1720
Advantage: 58

Beijing Minruida Technology Co., Ltd.

Tel: 010-82387566 18001021521;
Fax: 82387566-801
Email: sales@mreda.com.cn
Country: China
ProdList: 10789
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57423
Advantage: 58

TOSUN PHARM

Tel: 020-61855200 13326451905
Email: 260366801@qq.com
Country: China
ProdList: 7802
Advantage: 58

Zhejiang J&C Biological Technology Co.,Limited

Tel: +1-2135480471 +1-2135480471
Email: sales@sarms4muscle.com
Country: China
ProdList: 10473
Advantage: 58

Henan Pumei Jihua Pharmaceutical Technology Co., Ltd.

Tel: 037188900765 18037465274
Fax: QQ3430974218
Email: enyawanglei@sina.cn
Country: China
ProdList: 13758
Advantage: 58

Shanghai Yanze Chemical Co., Ltd.

Tel: 021-13773155751 19975051755
Email: 260924549@qq.com
Country: China
ProdList: 8913
Advantage: 58

Shanghai Kaiwei Chemical Technology Co., Ltd.

Tel: 021-58461859 15821823057
Email: service@aiviche.com
Country: China
ProdList: 49312
Advantage: 58

career henan chemical co

Tel: +86-0371-86658258 +8613203830695
Fax: 0086-371-86658258
Email: factory@coreychem.com
Country: China
ProdList: 29810
Advantage: 58

Guangzhou Younan Technology Co., Ltd

Tel: 020-82000279 18988968278
Fax: QQ：3283937693
Email: sales@ubiochem.com
Country: China
ProdList: 4297
Advantage: 58

Xi'an Lyna Bio-Tech Co., Ltd.

Tel: 029-84161958 18629577295
Fax: 029-84161958
Email: magic@lynabio.com
Country: China
ProdList: 1062
Advantage: 55

Shanghai Luofa Biochemical Technology Co., Ltd.

Tel: 021-51111890 15317326293
Email: sales@molnova.com
Country: China
ProdList: 4195
Advantage: 58

Henan Weitesi Chemical Technology Co. LTD

Tel: 0371-0371-55135753 18003832934
Fax: QQ：2853979818
Email: 2853979818@qq.com
Country: China
ProdList: 9998
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8140
Advantage: 58

cjbscvictory

Tel: 13348960310 13348960310
Email: 3003867561@qq.com
Country: China
ProdList: 10011
Advantage: 58

TCI (Shanghai) Chemical Trading Co., Ltd.

Tel: 021-021-61109150
Fax: 021-61105897
Email: sales@tcisct.com
Country: China
ProdList: 31121
Advantage: 58

JinOu Biomedical (Nanjing) Co., Ltd.

Tel: 13000000000
Fax: jinoupharma@163
Email: jinoupharma@163.com
Country: China
ProdList: 11721
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
ProdList: 62075
Advantage: 58

InvivoChem

Tel: 13549236410
Email: sales@invivochem.cn
Country: China
ProdList: 6753
Advantage: 58

Beijing Qinling Pharmaceutical Co., Ltd.

Tel: 010-61241352 18901327973
Email: 834537306@qq.com
Country: China
ProdList: 4843
Advantage: 58

Changsha Qisheng Heyan Medical Technology Co., LTD

Tel: 18684929597
Email: 527907673@qq.com
Country: China
ProdList: 103
Advantage: 58

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 18621169109
Email: market03@meryer.com
Country: China
ProdList: 27987
Advantage: 58

Shanghai Saikerui Biotechnology Co. , Ltd.

Tel: 021-58000709 15900491054
Email: info@scrbio.com
Country: China
ProdList: 10329
Advantage: 58

GUANGZHOU TOPWORK CHEMISTRY CO.,LTD.

Tel: 020-87317062 13048089691
Email: 852378519@qq.com
Country: China
ProdList: 160
Advantage: 58

Shanghai Easy CDMO Co.,Ltd

Tel: 021-61734564
Email: August@easycdmo.com
Country: China
ProdList: 10030
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 17801761073
Email: Gsiyu@solarbio.com
Country: China
ProdList: 50464
Advantage: 58

Shaanxi Istare Biotechnology Co., Ltd.

Tel: 18682931470
Email: 2142355700@qq.com
Country: China
ProdList: 4635
Advantage: 58

Hubei Moco Chemical Co., Ltd.

Tel: 18627753421 18627756402
Fax: QQ：3001051413
Email: 3001009495@qq.com
Country: China
ProdList: 19063
Advantage: 58

Shaanxi Xihua Chemical Industry Co., Ltd

Tel: 17691182729 13992773979
Email: 1049@dideu.com
Country: China
ProdList: 8158
Advantage: 58

Shanghai Weiyite Biotechnology Co., Ltd

Tel: 15317051735
Email: josie@wytsci.com
Country: China
ProdList: 7396
Advantage: 58

Moxin Chemicals

Tel: +8617320513646
Email: mike@molcoo.com
Country: China
ProdList: 9501
Advantage: 58

Hangzhou MolCore BioPharmatech Co.,Ltd.

Tel: +86-057181025280; +8617767106207
Fax: 0571-85806285
Email: sales@molcore.com
Country: China
ProdList: 49734
Advantage: 58

Hunan Yuanye Pharmaceutical Co., Ltd.

Tel: +8615857615745
Email: 2675013845@qq.com
Country: China
ProdList: 87
Advantage: 58

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6650
Advantage: 58

Guangzhou WeiBo Chemical Co., Ltd.

Tel: --
Fax: --
Email: weibochem@163.com
Country: China
ProdList: 6187
Advantage: 67

Less

View Lastest Price from GANAXOLONE manufacturers

Career Henan Chemical Co

Product: GANAXOLONE 38398-32-2
Price: US $0.01/KG
Min. Order: 1KG
Purity: 98%; 99%
Supply Ability: 500g;1kg； 25kg
Release date: 2020-01-09

38398-32-2, GANAXOLONERelated Search:

Sofalcone GANAXOLONE

3α-hydroxy-3β-methyl-5α-pregnan-20-one

(3α,5α)-3-Hydroxy-3-methyl-pregnan-20-one

1-((3R,5S,8R,9S,10S,13S,14S,17S)-3-Hydroxy-3,10,13-trimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethanone

(3α,5α)-3-Hydroxy-3-methylpregnan-20-one

1-[(3R,5S,8R,9S,10S,13S,14S,17S)-3-hydroxy-3,10,13-trimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]ethanone

Pregnan-20-one, 3-hydroxy-3-methyl-, (3α,5α)-

5α-PREGNAN-3β-METHYL-3α-OL-20-ONE

1-[(Chemicalbook3R,5S,8R,9S,10S,13S,14S,17S)-3-hydroxy-3,10,13-trimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]ethanone

3α-hydroxy-3β-methyl-5α-pregnan-20-one

5α-PREGNAN-3β-METHYL-3α-

Fampridine Impurity 80

Noradrenaline Impurity 69

38398-32-2