GANAXOLONE

Product Name: GANAXOLONE
CAS No.: 38398-32-2
Chemical Name: GANAXOLONE
Synonyms: Fampridine Impurity 80;5α-PREGNAN-3β-METHYL-3α-;Noradrenaline Impurity 69;5α-PREGNAN-3β-METHYL-3α-OL-20-ONE;3α-hydroxy-3β-methyl-5α-pregnan-20-one;3α-hydroxy-3β-methyl-5α-pregnan-20-one;(3α,5α)-3-Hydroxy-3-methylpregnan-20-one;(3α,5α)-3-Hydroxy-3-methyl-pregnan-20-one;Pregnan-20-one, 3-hydroxy-3-methyl-, (3α,5α)-;1-((3R,5S,8R,9S,10S,13S,14S,17S)-3-Hydroxy-3,10,13-trimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethanone
CBNumber: CB8498146
Molecular Formula: C22H36O2
Formula Weight: 332.52
MOL File: 38398-32-2.mol

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GANAXOLONE Property

Melting point:: 190-192°
alpha: D +103°
Boiling point:: 434.8±18.0 °C(Predicted)
Density: 1.036±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: ~4.2 mg/mL
form: solid
pka: 15.18±0.70(Predicted)
color: white

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
RTECS: TU4384700

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: G7795
Product name: Ganaxolone
Purity: solid
Packaging: 5mg
Price: $196
Updated: 2024/03/01

Sigma-Aldrich

Product number: G7795
Product name: Ganaxolone
Purity: solid
Packaging: 25mg
Price: $677
Updated: 2024/03/01

Cayman Chemical

Product number: 20919
Product name: Ganaxolone
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 20919
Product name: Ganaxolone
Purity: ≥98%
Packaging: 5mg
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 20919
Product name: Ganaxolone
Purity: ≥98%
Packaging: 10mg
Price: $153
Updated: 2024/03/01

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GANAXOLONE Chemical Properties,Usage,Production

Description

Ganaxolone is a 3β-methylated synthetic analog of the neurosteroid allopregnanolone that allosterically enhances GABA_A receptor current. At nanomolar concentrations, it can potentiate GABA-evoked currents at GABA_A receptor complexes containing α₁, α₂, α₃, β₂, and γ_2L subunits expressed in Xenopus oocytes. Ganaxolone has been shown to have a broad range of antiseizure activity in animal epilepsy models and human clinical trials.

Uses

Treatment of epilepsy and migraine.

Uses

Ganaxolone, is synthetic neuroactive steroid, which possess sedative, anxiolytic, and anticonvulsant properties. It is also a potent and selective positive allosteric modulator of GABAA receptors. It is also shown to be used for the treatment of epilepsy.

Definition

ChEBI: Ganaxolone is a corticosteroid hormone.

Biological Activity

Potent positive allosteric modulator of GABA A receptors. Enhances GABA-evoked chloride currents in Xenopus oocytes expressing GABA A receptors (EC 50 values are 94, 122 and 213 nM for α 2 β 1 γ 2 L , α 3 β 1 γ 2 L and α 1 β 1 γ 2 L receptors respectively). Exerts anticonvulsive effects in a broad range of animal seizure models.

Biochem/physiol Actions

Ganaxolone (3alpha-hydroxy-3beta-methyl-5alpha-pregnane-20-one) is a positive allosteric modulator of the GABAA receptor subtype; synthetic analog of the endogenous neurosteroid allopregnanolone; effective against chemically induced seizures in rats and mice. Ganaxolone is an orally active analog of allopregnanolone that is not converted to the hormonally active 3-keto form. The enhanced anticonvulsant potency of ganaxolone after neurosteroid withdrawal supports the use of ganaxolone as a specific treatment for perimenstrual catamenial epilepsy.

storage

+4°C

GANAXOLONE Preparation Products And Raw materials

Raw materials

Preparation Products

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GANAXOLONE Suppliers

China 48 Germany 1 India 4 Japan 1 South Korea 1 Switzerland 1 United Kingdom 4 United States 10 Global 70

Hunan Well Medicine Synthesis Technology Co., Ltd

Tel: 13574065797
Email: 3877753494@qq.com
Country: China
ProdList: 33
Advantage: 58

Bayee Biotech (Anqing) Co., Ltd.

Tel: 0556-5032306 18917961636
Fax: +86-556-5032307
Email: wtx@bayeebio.com
Country: China
ProdList: 261
Advantage: 61

Taizhou Nanfeng Pharmaceutical Research Institute

Tel: 18616377689
Email: nanfengdrug@163.com
Country: China
ProdList: 20000
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15839
Advantage: 69

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14103
Advantage: 59

WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.

Tel: 17702719238 17702719238
Email: sales@sun-shinechem.com
Country: China
ProdList: 985
Advantage: 64

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 14055
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Nanjing Sunlida Biological Technology Co., Ltd.

Tel: 025-57798810
Fax: 025-57019371
Email: sales@sunlidabio.com
Country: China
ProdList: 3239
Advantage: 55

Hangzhou J&H Chemical Co., Ltd.

Tel: 0571-+86-571-87396432
Fax: 0571-87396431
Email: sales@jhechem.com
Country: China
ProdList: 11578
Advantage: 59

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View Lastest Price from GANAXOLONE manufacturers

Career Henan Chemical Co

Product: GANAXOLONE 38398-32-2
Price: US $0.01/KG
Min. Order: 1KG
Purity: 98%; 99%
Supply Ability: 500g;1kg； 25kg
Release date: 2020-01-09

38398-32-2, GANAXOLONERelated Search:

Sofalcone GANAXOLONE

3α-hydroxy-3β-methyl-5α-pregnan-20-one

(3α,5α)-3-Hydroxy-3-methyl-pregnan-20-one

1-((3R,5S,8R,9S,10S,13S,14S,17S)-3-Hydroxy-3,10,13-trimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethanone

(3α,5α)-3-Hydroxy-3-methylpregnan-20-one

1-[(3R,5S,8R,9S,10S,13S,14S,17S)-3-hydroxy-3,10,13-trimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]ethanone

Pregnan-20-one, 3-hydroxy-3-methyl-, (3α,5α)-

Fampridine Impurity 80

5α-PREGNAN-3β-METHYL-3α-OL-20-ONE

1-[(Chemicalbook3R,5S,8R,9S,10S,13S,14S,17S)-3-hydroxy-3,10,13-trimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]ethanone

3α-hydroxy-3β-methyl-5α-pregnan-20-one

5α-PREGNAN-3β-METHYL-3α-

Noradrenaline Impurity 69

38398-32-2