ChemicalBook > CAS DataBase List > 3'-BROMO-4'-HYDROXYACETOPHENONE

3'-BROMO-4'-HYDROXYACETOPHENONE

Product Name
3'-BROMO-4'-HYDROXYACETOPHENONE
CAS No.
1836-06-2
Chemical Name
3'-BROMO-4'-HYDROXYACETOPHENONE
Synonyms
4-Acetyl-2-bromophenol;2-Bromo-4-acetylphenol;3'-BROMO-4'-HYDROXYACETOPHENONE;1-(3-Bromo-4-hydroxyphenyl)ethanone;Ethanone, 1-(3-bromo-4-hydroxyphenyl)-;1-(3-bromo-4-hydroxyphenyl)ethan-1-one
CBNumber
CB8498863
Molecular Formula
C8H7BrO2
Formula Weight
215.04
MOL File
1836-06-2.mol
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3'-BROMO-4'-HYDROXYACETOPHENONE Property

Melting point:
111.0 to 115.0 °C
Boiling point:
315.9±27.0 °C(Predicted)
Density 
1.586±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
soluble in Methanol
form 
powder to crystal
pka
6.63±0.18(Predicted)
color 
White to Light yellow to Light orange
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
26-36
HS Code 
2914790090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
B5158
Product name
3'-Bromo-4'-hydroxyacetophenone
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$359
Updated
2025/07/31
TRC
Product number
B993405
Product name
1-(3-Bromo-4-hydroxyphenyl)ethanone
Packaging
100mg
Price
$310
Updated
2021/12/16
TRC
Product number
B993405
Product name
1-(3-Bromo-4-hydroxyphenyl)ethanone
Packaging
10mg
Price
$45
Updated
2021/12/16
AK Scientific
Product number
X3577
Product name
1-(3-Bromo-4-hydroxyphenyl)ethanone
Packaging
250mg
Price
$39
Updated
2021/12/16
AK Scientific
Product number
J97801
Product name
1-(3-Bromo-4-hydroxyphenyl)ethanone
Packaging
1g
Price
$63
Updated
2021/12/16
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3'-BROMO-4'-HYDROXYACETOPHENONE Chemical Properties,Usage,Production

Preparation

Preparation by diazotization of 5-amino-3-bromo-2- hydroxyacetophenone, followed by hydrolysis of the obtained diazonium salt (50%).

Synthesis

95-56-7

75-36-5

1836-06-2

2-Bromophenol (1.16 mL, 10.0 mmol) was dissolved in carbon disulfide (10 mL) and stirred under cooling in an ice-salt bath. Subsequently, anhydrous aluminum chloride (2.7 g, 20.0 mmol) was added in batches, followed by slow dropwise addition of acetyl chloride (0.754 mL, 11.0 mmol). The reaction mixture was maintained under stirring conditions for 1 hour and then refluxed overnight. Upon completion of the reaction, the mixture was quenched by adding a mixture of 1 M hydrochloric acid and ice to the mixture. The mixture was extracted using dichloromethane (3 times) and after combining the organic phases, it was dried and concentrated with anhydrous sodium sulfate. The residue was purified by silica gel column chromatography (eluent: 20% ethyl acetate/hexane to 40% ethyl acetate/hexane gradient elution) to afford the target product 3-bromo-4-hydroxyacetophenone (2.28 g, 53% yield).

References

[1] Journal of Medicinal Chemistry, 1980, vol. 23, # 7, p. 738 - 744
[2] Patent: WO2004/62661, 2004, A1. Location in patent: Page/Page column 27

3'-BROMO-4'-HYDROXYACETOPHENONE Preparation Products And Raw materials

Raw materials

Preparation Products

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3'-BROMO-4'-HYDROXYACETOPHENONE Suppliers

Americas 1 China 65 Europe 1 India 3 Japan 1 Switzerland 1 United States 7 Global 79
Accela ChemBio Inc.
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View Lastest Price from 3'-BROMO-4'-HYDROXYACETOPHENONE manufacturers

Career Henan Chemical Co
Product
3'-BROMO-4'-HYDROXYACETOPHENONE 1836-06-2
Price
US $9.80/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
1kg -1000kg
Release date
2020-01-03

1836-06-2, 3'-BROMO-4'-HYDROXYACETOPHENONERelated Search:

4'-Hydroxyacetophenone

  • 3'-BROMO-4'-HYDROXYACETOPHENONE
  • 1-(3-Bromo-4-hydroxyphenyl)ethanone
  • 2-Bromo-4-acetylphenol
  • 4-Acetyl-2-bromophenol
  • 1-(3-bromo-4-hydroxyphenyl)ethan-1-one
  • Ethanone, 1-(3-bromo-4-hydroxyphenyl)-
  • 1836-06-2
  • 1836-06-3