TICRYNAFEN
- Product Name
- TICRYNAFEN
- CAS No.
- 40180-04-9
- Chemical Name
- TICRYNAFEN
- Synonyms
- Tienilic;Tienilic Acid - Ticrynafan;ticrex;fr3068;ce3624;ANP 362;anp3624;diflurex;skf62698;selacryn
- CBNumber
- CB8500854
- Molecular Formula
- C13H8Cl2O4S
- Formula Weight
- 331.17
- MOL File
- 40180-04-9.mol
TICRYNAFEN Property
- Melting point:
- 148-149oC
- Boiling point:
- 534.6±50.0 °C(Predicted)
- Density
- 1.532
- storage temp.
- -20°C
- solubility
- DMSO: soluble5mg/mL (clear solution)
- pka
- 2.79±0.10(Predicted)
- form
- powder
- color
- white to beige
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML0505
- Product name
- Tienilic Acid
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $94.4
- Updated
- 2024/03/01
- Product number
- SML0505
- Product name
- Tienilic Acid
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $386
- Updated
- 2024/03/01
- Product number
- 10008517
- Product name
- Tienilic Acid
- Purity
- ≥99%
- Packaging
- 5mg
- Price
- $72
- Updated
- 2024/03/01
- Product number
- 10008517
- Product name
- Tienilic Acid
- Purity
- ≥99%
- Packaging
- 10mg
- Price
- $120
- Updated
- 2024/03/01
- Product number
- 10008517
- Product name
- Tienilic Acid
- Purity
- ≥99%
- Packaging
- 25mg
- Price
- $319
- Updated
- 2024/03/01
TICRYNAFEN Chemical Properties,Usage,Production
Description
Cytochrome P450 enzymes function to metabolize both endogenous and exogenous compounds. Both the 3A and 2C isoforms are present in human liver of which CYP2C9 seems most highly expressed. Tienilic acid is a specific suicide substrate for CYP2C9 and CYP2C10 whereby its oxidation inactivates the enzyme. The time required to inactivate one half of the CYP2C10 enzyme at the maximal rate (t½max) is 3.4 minutes, with a dissociation constant (KI) value of 4.3 μM.
Chemical Properties
Pale Beige Solid
Uses
A heterocycloc derivative of phenoxyacetic Acid. Uses as a diuretic, uricosuric, anhtihypertensive
Uses
Tienilic Acid is a heterocyclic derivative of phenoxyacetic acid. Tienilic acid is used as diuretic, uricosuric, antihypertensive.
Definition
ChEBI: An aromatic ketone that is 2,3-dichlorophenoxyacetic acid in which the hydrogen at position 4 on the benzene ring is replaced by a thiophenecarbonyl group. A loop diuretic used to treat hypertension, it was withdrawn from the market in 1982 due to links wi h hepatitis.
brand name
Tienilic Acid is INN and BAN;Anp 3624;Diflarex;Fr 3068;Selcryn;Skf-62698;Ticrynafen;Ticrynapen.
World Health Organization (WHO)
Tienilic acid, a diuretic agent with uricosuric and antihypertensive activity, was introduced in 1976. By 1979 its use had been associated with cases of hepatic toxicity, some of which were fatal, which led to the withdrawal of the drug in most countries in which it was marketed. In France, however, precautions regarding the use of tienilic acid were issued by the Pharmacovigilance Commission and the drug remained available for another decade. In 1991, it was eventually also withdrawn there since cases of hepatitis, some of which were fulminant, had continued to occur.
Biochem/physiol Actions
Tienilic Acid (Ticrynafen) is a P450 inhibitor, a specific suicide substrate for CYP2C9 and CYP2C10. It was once used as a loop diuretic drug with uric acid-lowering (uricosuric) actvity, but was removed from market because of hepatotoxicity.
TICRYNAFEN Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from TICRYNAFEN manufacturers
- Product
- TICRYNAFEN 40180-04-9
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-07-06
- Product
- Tienilic Acid 40180-04-9
- Price
- US $0.10/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 1000 tons
- Release date
- 2020-01-02