TICRYNAFEN

Product Name: TICRYNAFEN
CAS No.: 40180-04-9
Chemical Name: TICRYNAFEN
Synonyms: Tienilic;Tienilic Acid - Ticrynafan;ticrex;fr3068;ce3624;ANP 362;anp3624;diflurex;skf62698;selacryn
CBNumber: CB8500854
Molecular Formula: C13H8Cl2O4S
Formula Weight: 331.17
MOL File: 40180-04-9.mol

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TICRYNAFEN Property

Melting point:: 148-149oC
Boiling point:: 534.6±50.0 °C(Predicted)
Density: 1.532
storage temp.: -20°C
solubility: DMSO: soluble5mg/mL (clear solution)
pka: 2.79±0.10(Predicted)
form: powder
color: white to beige

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3
RTECS: AG9300000
Toxicity: LD50 in mice (mg/kg): 225 i.v., 1275 orally (US 3758506)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0505
Product name: Tienilic Acid
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $94.4
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0505
Product name: Tienilic Acid
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $386
Updated: 2024/03/01

Cayman Chemical

Product number: 10008517
Product name: Tienilic Acid
Purity: ≥99%
Packaging: 5mg
Price: $72
Updated: 2024/03/01

Cayman Chemical

Product number: 10008517
Product name: Tienilic Acid
Purity: ≥99%
Packaging: 10mg
Price: $120
Updated: 2024/03/01

Cayman Chemical

Product number: 10008517
Product name: Tienilic Acid
Purity: ≥99%
Packaging: 25mg
Price: $319
Updated: 2024/03/01

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TICRYNAFEN Chemical Properties,Usage,Production

Description

Cytochrome P450 enzymes function to metabolize both endogenous and exogenous compounds. Both the 3A and 2C isoforms are present in human liver of which CYP2C9 seems most highly expressed. Tienilic acid is a specific suicide substrate for CYP2C9 and CYP2C10 whereby its oxidation inactivates the enzyme. The time required to inactivate one half of the CYP2C10 enzyme at the maximal rate (t_½max) is 3.4 minutes, with a dissociation constant (KI) value of 4.3 μM.

Chemical Properties

Pale Beige Solid

Uses

A heterocycloc derivative of phenoxyacetic Acid. Uses as a diuretic, uricosuric, anhtihypertensive

Uses

Tienilic Acid is a heterocyclic derivative of phenoxyacetic acid. Tienilic acid is used as diuretic, uricosuric, antihypertensive.

Definition

ChEBI: An aromatic ketone that is 2,3-dichlorophenoxyacetic acid in which the hydrogen at position 4 on the benzene ring is replaced by a thiophenecarbonyl group. A loop diuretic used to treat hypertension, it was withdrawn from the market in 1982 due to links wi h hepatitis.

brand name

Tienilic Acid is INN and BAN;Anp 3624;Diflarex;Fr 3068;Selcryn;Skf-62698;Ticrynafen;Ticrynapen.

World Health Organization (WHO)

Tienilic acid, a diuretic agent with uricosuric and antihypertensive activity, was introduced in 1976. By 1979 its use had been associated with cases of hepatic toxicity, some of which were fatal, which led to the withdrawal of the drug in most countries in which it was marketed. In France, however, precautions regarding the use of tienilic acid were issued by the Pharmacovigilance Commission and the drug remained available for another decade. In 1991, it was eventually also withdrawn there since cases of hepatitis, some of which were fulminant, had continued to occur.

Biochem/physiol Actions

Tienilic Acid (Ticrynafen) is a P450 inhibitor, a specific suicide substrate for CYP2C9 and CYP2C10. It was once used as a loop diuretic drug with uric acid-lowering (uricosuric) actvity, but was removed from market because of hepatotoxicity.

TICRYNAFEN Preparation Products And Raw materials

Raw materials

Preparation Products

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TICRYNAFEN Suppliers

Canada 1 China 87 Germany 1 India 3 United Kingdom 1 United States 13 Global 106

Henan Kehong Biological Technology Co. LTD

Tel: 17722895060 19139748274
Fax: QQ：3311217266
Email: info@kehobio.com
Country: China
ProdList: 2415
Advantage: 58

Shanghai Boyle Chemical Co., Ltd.

Tel: 021-50182298 021-50180596
Fax: +86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2208
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J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Syntechem Co.,Ltd

Tel
Fax: E-Mail Inquiry
Email: info@syntechem.com
Country: China
ProdList: 12984
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Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4727
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Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 41462
Advantage: 60

Chengdu Firster Pharmaceutical Co., Ltd.

Tel: 028-87078428 028-87074958
Fax: 8772-8116
Email: chengzhenyong@cdfirster.com
Country: China
ProdList: 2677
Advantage: 60

Finetech Industry Limited

Tel: 027-87465837 19945049750
Fax: 027-8777-2287
Email: sales@finetechnology-ind.com
Country: China
ProdList: 9648
Advantage: 58

Shanghai Kewel Chemical Co., Ltd.

Tel: 021-64609169 18901607656
Fax: 021-64609160
Email: greensnown@163.com
Country: China
ProdList: 9906
Advantage: 50

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View Lastest Price from TICRYNAFEN manufacturers

Dideu Industries Group Limited

Product: TICRYNAFEN 40180-04-9
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-07-06

40180-04-9, TICRYNAFENRelated Search:

Pentasodium DTPA Fusidine 2-[2,3-dichloro-4-(5-hydroxythiophene-2-carbonyl)phenoxy]acetic acid [2,3-Dichloro-4-[(2-thienyl)hydroxymethyl]phenoxy]acetic acid Ethacrynic acid 2,3-Dichloro-4-hydroxybenzaldehyde 2,3-DICHLOROPHENOXYACETIC ACID 3-CHLORO-4-METHOXYACETOPHENONE 2-(4-METHOXYBENZOYL)THIOPHENE 2,3-Dichloroacetophenone 2'-CHLORO-4'-HYDROXYACETOPHENONE TICRYNAFEN CHEMBRDG-BB 4015100 1-(3-chloro-4-ethoxyphenyl)ethanone CHEMBRDG-BB 4008742 1-(3-CHLORO-4-HYDROXYPHENYL)-1-ETHANONE AKOS 91369 2-Methoxyethyl (2,3-dichloro-4-(2-thienylcarbonyl)phenoxy)acetate

Tienilic Acid - Ticrynafan

ANP 362

ce3624

diflurex

fr3068

selacryn

skf62698

thienylicacid

ticrex

(2,3-dichloro-4-(2-thenoyl)phenoxy)aceticacid

(2,3-dichloro-4-(2-thienylcarbonyl)phenoxy)-aceticaci

(2,3-dichloro-4-(2-thienylcarbonyl)phenoxy)aceticacid

(2,3-dichloro-4-(2-thiophenecarbonyl)phenoxy)aceticacid

4-(2-theonyl)-2,3-dichlorphenoxyessigsaeure

4-(2-thienylketo)-2,3-dichlorophenoxyaceticacid

anp3624

tienilicacid

[2,3-Dichloro-4-(2-thienylcarbonyl)phenoxy]aceticAcid,TienilicAcid,ThienylicAcid,ANP-3624,CE-3624,SKF-62698,Dif

[2,3-Dichloro-4-(2-thienylcarbonyl)phenoxy]acetic Acid, Tienilic Acid, Thienylic Acid, ANP-3624, CE-3624, SKF-62698, Diflurex, Selacryn

Tienilic

TIENILIC ACID(TICRYNAFEN)

4-(2-Thienylcarbonyl)-2,3-dichlorophenoxyacetic acid

Difluorex

Tienylic acid

2-[2,3-Dichloro-4-(2-thienylcarbonyl)phenoxy]acetic Acid

4-(2-Thenoyl)-2,3-dichlorophenoxyacetic Acid

2-{2,3-dichloro-4-[(thiophen-2-yl)carbonyl]phenoxy}acetic acid

2-(2,3-dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid

Acetic acid, 2-[2,3-dichloro-4-(2-thienylcarbonyl)phenoxy]-

Tienilic Acid Solution, 100ppm

TICRYNAFEN USP/EP/BP

TICRYNAFEN ISO 9001：2015 REACH

Ticrynafen, Tienilic acid

ANP 3624,Tienilic Acid,Inhibitor,Uricosuric,Diuretic,inhibit,Hepatotoxicity,ANP3624,Ticrynafen,ANP-3624

ienilicaci

Tinic acid（Axitinib Impurity 18）

2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid（Tienilic Acid）

40180-04-9

Aromatics

Sulfur & Selenium Compounds

Heterocyclic Compounds

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals