AMINOPENTAMIDE SULFATE (200 MG)

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AMINOPENTAMIDE SULFATE (200 MG)

Product Name: AMINOPENTAMIDE SULFATE (200 MG)
CAS No.: 60-46-8
Chemical Name: AMINOPENTAMIDE SULFATE (200 MG)
Synonyms: BL-139;Centrine;dimevamide;Valeramide-OM;Aminopentamide;RSYYDimevamide;Aminopentamid Sulfate;Methadone Impurity 28;AMINOPENTAMIDE SULFATE;AMINOPENTAMIDE SULFATE (200 MG)
CBNumber: CB8501624
Molecular Formula: C19H24N2O
Formula Weight: 296.41
MOL File: 60-46-8.mol

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AMINOPENTAMIDE SULFATE (200 MG) Property

Melting point:: 178-179℃
Boiling point:: 438°C (rough estimate)
Density: 1.069±0.06 g/cm3 (20 ºC 760 Torr)
refractive index: 1.5600 (estimate)
storage temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility: Methanol (Slightly), Water (Slightly)
pka: 15.73±0.50(Predicted)
form: Solid
color: White to Off-White
Stability:: Hygroscopic

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: CHM0311687
Product name: 4-(DIMETHYLAMINO)-2,2-DIPHENYLPENTANAMIDE
Purity: 95.00%
Packaging: 5MG
Price: $498.09
Updated: 2021/12/16

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AMINOPENTAMIDE SULFATE (200 MG) Chemical Properties,Usage,Production

Originator

Centrine,Bristol,US,1953

Uses

Aminopentamide Sulfate affects gastric function and gastroduodenal ulcus. Used in the treatment of vomiting, diarrhea and other side effects in dogs/cats.

Definition

ChEBI: 4-(dimethylamino)-2,2-diphenylpentanamide is a diarylmethane.

Manufacturing Process

A mixture of 14 g (0.05 mol) of α,α-diphenyl-γ-dimethylaminovaleronitrile, 16 g (0.2 mol) of sodium acetate, 14 g (0.2 mol) of hydroxylamine hydrochloride and 75 ml of ethyl alcohol was refluxed 18 hours. The mixture was cooled, poured into water and neutralized with ammonium hydroxide. The heavy white precipitate solidified on standing. The material was filtered and recrystallized from isopropanol. After three recrystallizations the aminopentamide product melted at 177° to 179°C.
The product is often used as the acid sulfate which is produced as follows: 252.0 g (0.85 mol) of α,α-diphenyl-γ-dimethylaminovaleronitrile was dissolved in one liter of isopropanol, and 70 ml of concentrated sulfuric acid was added as rapidly as possible. The mixture was heated until clear, then filtered and diluted with 1,500 ml of anhydrous ethyl acetate. The solution was cooled and filtered, and the white crystalline product was dried in vacuum over P2O5.

Therapeutic Function

Anticholinergic

Purification Methods

Crystallise dimevamide from aqueous EtOH. The hydrochloride forms leaflets from EtOH/Et2O with m 190-191o and is deliquescent. The picrate has m 210-211o. It is an antispasmotic. [Moffett et al. J Am Chem Soc 79 4451, 4457 1957, Beckett J Pharm Pharmacol 8 848 1956, Beilstein 14 III 1363, 14 IV 1865.]

AMINOPENTAMIDE SULFATE (200 MG) Preparation Products And Raw materials

Raw materials

Valeronitrile Diphenylacetonitrile

Preparation Products

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