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Valeronitrile

Product Name
Valeronitrile
CAS No.
110-59-8
Chemical Name
Valeronitrile
Synonyms
NITRILE C5;zhnegwujin;1-Cyanbutan;Butylcyanid;CH3(CH2)3CN;PENTANITRILE;Valeronitril;BUTYL CYANIDE;VALERONITRILE;1-Cyanobutane
CBNumber
CB2250133
Molecular Formula
C5H9N
Formula Weight
83.13
MOL File
110-59-8.mol
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Valeronitrile Property

Melting point:
−96 °C(lit.)
Boiling point:
139-141 °C(lit.)
Density 
0.795 g/mL at 25 °C(lit.)
vapor pressure 
7.0 hPa (20 °C)
refractive index 
n20/D 1.397(lit.)
Flash point:
105 °F
storage temp. 
Store below +30°C.
solubility 
10.0g/l
form 
Liquid
color 
Clear colorless
Water Solubility 
0.1-0.5 g/100 mL at 22.5 ºC
Merck 
14,9905
BRN 
1736706
Stability:
Stable. Incompatible with strong acids, strong bases, strong oxidizing agents, strong reducing agents. Flammable.
InChIKey
RFFFKMOABOFIDF-UHFFFAOYSA-N
CAS DataBase Reference
110-59-8(CAS DataBase Reference)
NIST Chemistry Reference
Pentanenitrile(110-59-8)
EPA Substance Registry System
Valeronitrile (110-59-8)
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Safety

Hazard Codes 
T
Risk Statements 
10-25-2017/10/25
Safety Statements 
36/37/39-45-16
RIDADR 
UN 1992 3/PG 3
WGK Germany 
3
RTECS 
YV8195000
Autoignition Temperature
520 °C
TSCA 
Yes
HazardClass 
3
PackingGroup 
III
HS Code 
29269095
HS Code 
29332100
Toxicity
LD50 orally in male mice: 2.297 mmol/kg (Tanii)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H226Flammable liquid and vapour

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P370+P378In case of fire: Use … for extinction.

P405Store locked up.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
155098
Product name
Valeronitrile
Purity
99.5%
Packaging
100g
Price
$66.1
Updated
2021/12/16
Sigma-Aldrich
Product number
8.08514
Product name
Pentanonitrile for synthesis. CAS 110-59-8, EC Number 203-781-8, chemical formula CH (CH ) CN., for synthesis
Packaging
8085140100
Price
$74.7
Updated
2021/12/16
Sigma-Aldrich
Product number
8.08514
Product name
Pentanonitrile
Purity
for synthesis
Packaging
100 mL
Price
$77.3
Updated
2021/12/16
TCI Chemical
Product number
V0008
Product name
Valeronitrile
Purity
>98.0%(GC)
Packaging
25mL
Price
$23
Updated
2021/12/16
TCI Chemical
Product number
V0008
Product name
Valeronitrile
Purity
>98.0%(GC)
Packaging
500mL
Price
$177
Updated
2021/12/16
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Valeronitrile Chemical Properties,Usage,Production

Chemical Properties

Clear liquid

Uses

Valeronitrile is used as building block in organic synthesis. Product Data Sheet

Uses

Solvent.

Uses

Valeronitrile is used in the preparation of valeric acid. It is also used to enhance the nitrilase activity in many strains.

Production Methods

Valeronitrile can be synthesized by dehydration of valeronamide. The nitrile is also found in nature and is a constituent of coal gasification and oil shale processing waste water, sewage wastewater and tobacco smoke.

General Description

Clear colorless to yellow liquid.

Air & Water Reactions

Slightly soluble in water.

Reactivity Profile

Nitriles, such as Valeronitrile, may polymerize in the presence of metals and some metal compounds. They are incompatible with acids; mixing nitriles with strong oxidizing acids can lead to extremely violent reactions. Nitriles are generally incompatible with other oxidizing agents such as peroxides and epoxides. The combination of bases and nitriles can produce hydrogen cyanide. Nitriles are hydrolyzed in both aqueous acid and base to give carboxylic acids (or salts of carboxylic acids). These reactions generate heat. Peroxides convert nitriles to amides. Nitriles can react vigorously with reducing agents. Acetonitrile and propionitrile are soluble in water, but nitriles higher than propionitrile have low aqueous solubility. They are also insoluble in aqueous acids. Valeronitrile is incompatible with strong acids, strong bases, strong oxidizing agents and strong reducing agents. .

Health Hazard

Valeronitrile is an irritant and may be harmful by inhalation, ingestion or skin absorption .

Fire Hazard

Valeronitrile is combustible.

Industrial uses

Valeronitrile is used as an industrial solvent and as a chemical intermediate.

Metabolism

As with other aliphatic nitriles, valeronitrile is metabolized in vivo resulting in the liberation of cyanide ion which is responsible for much of the observed toxicity of this compound . Biotransformation of valeronitrile presumably proceeds in a manner similar to that of other aliphatic nitriles with an initial cytochrome P-450 catalyzed oxidation of the nitrile to the cyanohydrin followed by release of the cyanide group from the activated molecule. Cyanide formation was significantly reduced when valeronitrile was incubated with mouse hepatic microsomes in the presence of SKF-525A or carbon monoxide or when microsomes from mice pretreated with chloroform were used . Ethanol pretreatment of mice markedly increases the in vivo and in vitro microsomal oxidation of valeronitrile presumably as a result of increased levels of an ethanol inducible cytochrome P-450 . As with other nitriles, the cyanide released upon biotransformation of valeronitrile is readily converted to thiocyanate in vivo and the latter ion was the major urinary excretion product observed with valero-nitrile in rats . From 18 to 31% of a daily 175 mg/kg dose of valeronitrile was eliminated in the urine as thiocyanate during a 24 h period. In another study , 43.2 and 27.5%, respectively, of an oral or i.p. dose of 0.75 mmol/kg valeronitrile was excreted as thiocyanate in the urine of male Sprague-Dawley rats over a 24 h period.

Purification Methods

Wash the nitrile with half its volume of conc HCl (twice), then with saturated aqueous NaHCO3, dry it with MgSO4 and fractionally distil it from P2O5. [Beilstein 2 H 301, 2 I 131, 2 II 267, 2 III 675, 2 IV 875.]

Valeronitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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Valeronitrile Suppliers

Wuhan Greatwall chemical Co,.LTD
Tel
400-027-6116
Fax
QQ: 2680733325
Email
sales@chemgreatwall.com
Country
China
ProdList
1563
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55
Nanjing Lanbai Chemical Co., Ltd.
Tel
025-85499326;025-85499316
Fax
025-8549-9357
Email
1911566570@qq.com;1911566570@qq.com
Country
China
ProdList
140
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57
Shanghai Billion Chemical Chemical Co. Ltd.
Tel
021-58771921-
Fax
QQ: 3440059551
Email
info@chemofchina.com;
Country
China
ProdList
2999
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
21-61259100-
Fax
86-21-61259102
Email
sh@meryer.com
Country
China
ProdList
40264
Advantage
62
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15877
Advantage
69
Alfa Aesar
Tel
400-610-6006; 021-67582000
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30159
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386 / 800-988-0390
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24555
Advantage
81
Beijing dtftchem Technology Co., Ltd.
Tel
13651141086; 86(10)60275028、60275820
Fax
86 (10) 60270825
Email
dtftchem@sina.com
Country
China
ProdList
3392
Advantage
62
Energy Chemical
Tel
021-58432009-
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
43430
Advantage
61
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View Lastest Price from Valeronitrile manufacturers

Shanxi Naipu Import and Export Co.,Ltd
Product
Valeronitrile 110-59-8
Price
US $120.00/KG
Min. Order
1KG
Purity
99
Supply Ability
5tons
Release date
2021-03-16
Career Henan Chemical Co
Product
Valeronitrile 110-59-8
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000KGS
Release date
2020-01-02

110-59-8, ValeronitrileRelated Search:


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