BAX INHIBITING PEPTIDE V5 (BIP-V5)

Product Name: BAX INHIBITING PEPTIDE V5 (BIP-V5)
CAS No.: 579492-81-2
Chemical Name: BAX INHIBITING PEPTIDE V5 (BIP-V5)
Synonyms: Val-Pro-Met-Leu-Lys;VAL-PRO-MET-LEU-LYS;BIP-V5;Bax inhibitor peptide V5 TFA;BAX INHIBITOR PEPTIDE V5, >99%;Bax inhibitor peptide V5 (BIP-V5);BAX INHIBITING PEPTIDE V5 (BIP-V5);L-Lysine, L-valyl-L-prolyl-L-methionyl-L-leucyl-;VAL-PRO-MET-LEU-LYS;BIP-V5;BAX INHIBITING PEPTIDE V5;BAX Inhibiting Peptide V5 >=97% (HPLC), lyophilized powder;Bax inhibitor peptide V5，Val-Pro-Met-Leu-Lys， BIP-V5，BAX Inhibiting Peptide V5
CBNumber: CB8503178
Molecular Formula: C27H50N6O6S
Formula Weight: 586.79
MOL File: 579492-81-2.mol

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BAX INHIBITING PEPTIDE V5 (BIP-V5) Property

Boiling point:: 907.2±65.0 °C(Predicted)
Density: 1.185±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: ≥29.35 mg/mL in DMSO; insoluble in EtOH; ≥91.4 mg/mL in H2O
form: lyophilized powder
pka: 3.31±0.10(Predicted)
color: White to off-white

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: B1436
Product name: BAX Inhibiting Peptide V5
Purity: ≥97% (HPLC), lyophilized powder
Packaging: 5mg
Price: $188
Updated: 2024/03/01

Cayman Chemical

Product number: 30243
Product name: Bax Inhibitor Peptide V5
Packaging: 1mg
Price: $36
Updated: 2024/03/01

Cayman Chemical

Product number: 30243
Product name: Bax Inhibitor Peptide V5
Packaging: 10mg
Price: $308
Updated: 2024/03/01

Cayman Chemical

Product number: 30243
Product name: Bax Inhibitor Peptide V5
Packaging: 5mg
Price: $163
Updated: 2024/03/01

TRC

Product number: B129293
Product name: BaxInhibitorPeptideV5
Packaging: 10mg
Price: $495
Updated: 2021/12/16

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BAX INHIBITING PEPTIDE V5 (BIP-V5) Chemical Properties,Usage,Production

Description

Bax inhibitor peptide V5 is an inhibitor of Bax. It decreases levels of the pro-apoptotic proteins Bax, Bad, and NF-ĸB p65 and increases levels of the anti-apoptotic proteins X-linked inhibitor of apoptosis (XIAP) and Bcl-2 in isolated mouse pancreatic islets when used at a concentration of 100 μM. It inhibits apoptosis induced by etoposide in Hep3B human hepatoma cells when used at a concentration of 200 μM. Bax inhibitor peptide V5 (5 mg/ml, i.c.v.) decreases infarct volume and reduces ipsilateral paw preference in the cylinder rearing test, indicating an improvement in sensorimotor function, in a neonatal mouse model of hypoxic-ischemia brain injury induced by carotid artery ligation. Bax inhibitor peptide V5, when used at a concentration of 100 μM in syngeneic pancreatic islet cells prior to transplantation, inhibits increases in blood glucose levels in an intraperitoneal glucose tolerance test and increases survival in a mouse model of diabetes induced by streptozotocin (STZ; ).

Biochem/physiol Actions

BAX Inhibiting Peptide V5 protects Bax against conformational changes and it also prevents mitochondrial translocation. In vitro analysis prove that peptide V5 prevents apoptosis, mediated by a number of agents including staurosporine, ultraviolet and anti-cancer drug.

References

[1]. sawada m, hayes p, matsuyama s. cytoprotective membrane-permeable peptides designed from the bax-binding domain of ku70. nat cell biol, 2003, 5(4): 352-357.
[2]. rivas-carrillo jd, soto-gutierrez a, navarro-alvarez n, et al. cell-permeable pentapeptide v5 inhibits apoptosis and enhances insulin secretion, allowing experimental single-donor islet transplantation in mice. diabetes, 2007, 56(5): 1259-1267.

BAX INHIBITING PEPTIDE V5 (BIP-V5) Preparation Products And Raw materials

Raw materials

Preparation Products

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BAX INHIBITING PEPTIDE V5 (BIP-V5) Suppliers

China 52 Switzerland 1 United Kingdom 1 United States 12 Global 66

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View Lastest Price from BAX INHIBITING PEPTIDE V5 (BIP-V5) manufacturers

Career Henan Chemical Co

Product: BAX INHIBITING PEPTIDE V5 (BIP-V5) 579492-81-2
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2020-02-18

579492-81-2, BAX INHIBITING PEPTIDE V5 (BIP-V5)Related Search:

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579492-81-2

C27H50N6O6S