OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS)
- Product Name
- OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS)
- CAS No.
- 88546-55-8
- Chemical Name
- OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS)
- Synonyms
- OMEPRAZOLE SULPHONE;OMeprazole Related CoMpound A;5-Methoxy-2-(((4-Methoxy-3,5-diMethylpyridin-2-yl)Methyl)sulfonyl)-1H-benzo[d]iMidazole;H168/66;Amlodipine Impurity F;Esomeprazole USP RC A;EsoMeprazol iMpurity D;OMeprazole EP IMpurity D;EsoMeprazole iMpurity D;(OMEPRAZOLE SULFONE) (AS)
- CBNumber
- CB8505783
- Molecular Formula
- C17H19N3O4S
- Formula Weight
- 361.42
- MOL File
- 88546-55-8.mol
OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS) Property
- Melting point:
- 80-82°C
- Boiling point:
- 599.3±60.0 °C(Predicted)
- Density
- 1.331±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- ≥40.6 mg/mL in DMSO,≥19.9 mg/mL in EtOH,insoluble in H2O
- form
- Solid
- pka
- 7.97±0.10(Predicted)
- color
- White to off-white
- BRN
- 8347309
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 94319
- Product name
- Omeprazole sulfone
- Purity
- analytical standard
- Packaging
- 5mg
- Price
- $408
- Updated
- 2024/03/01
- Product number
- 1478516
- Product name
- Omeprazole Related Compound A
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 15mg
- Price
- $1380
- Updated
- 2024/03/01
- Product number
- 18882
- Product name
- Omeprazole sulfone
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $86
- Updated
- 2024/03/01
- Product number
- 18882
- Product name
- Omeprazole sulfone
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $161
- Updated
- 2024/03/01
- Product number
- PHR1648
- Product name
- Omeprazole Sulfone
- Purity
- Pharmaceutical Secondary Standard; Certified Reference Material
- Packaging
- 30mg
- Price
- $711
- Updated
- 2024/03/01
OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS) Chemical Properties,Usage,Production
Description
Omeprazole sulfone is the major metabolite of the gastric proton pump inhibitor, omeprazole . It is produced by cytochrome P450 (CYP)3A4 sulfoxidation of esomeprazole and is found in plasma. Omeprazole sulfone has been shown to act as a reversible direct-acting and metabolism-dependent inhibitor of CYP2C19 in pooled human liver microsomes (IC50 = 18 μM).
Chemical Properties
Light Yellow Solid
Uses
A metabolite of Omeprazole.
Definition
ChEBI: Omeprazole sulfone is a sulfoxide and a member of benzimidazoles.
in vitro
omeprazole sulfone has been shown to act as a reversible direct-acting and metabolism-dependent inhibitor of cyp2c19 in pooled human liver microsomes with an ic50 of 18 μm [1].
in vivo
three hours after intake of 20 mg omeprazole only, the geometric mean plasma concentration of omeprazole sulfone were 106 nmol/l in 22 samples from subjects known to be extensive cyp2c19 metabolizers (em) and 672 nmol/l in the five subjects known to be poor cyp2c19 metabolizers (pm). the mean log10(omeprazole/omeprazole sulfone) ratio was 0.18 [4].
References
[1] nebert d w, russell d w. clinical importance of the cytochromes p450[j]. the lancet, 2002, 360(9340): 1155-1162.
[2] bel a, andersson t b, antonsson m, et al. stereoselective metabolism of omeprazole by human cytochrome p450 enzymes[j]. drug metabolism and disposition, 2000, 28(8): 966-972.
[3] nebert d w, russell d w. clinical importance of the cytochromes p450[j]. the lancet, 2002, 360(9340): 1155-1162.
[4] bttiger y. use of omeprazole sulfone in a single plasma sample as a probe for cyp3a4[j]. european journal of clinical pharmacology, 2006, 62(8): 621-625.
OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS) Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS) manufacturers
- Product
- Omeprazole Impurity D 88546-55-8
- Price
- US $0.00-0.00/mg
- Min. Order
- 10mg
- Purity
- 0.98
- Supply Ability
- 10g
- Release date
- 2024-05-17
- Product
- OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS) 88546-55-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1000KG
- Release date
- 2018-08-08