ChemicalBook > CAS DataBase List > OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS)

OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS)

Product Name
OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS)
CAS No.
88546-55-8
Chemical Name
OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS)
Synonyms
OMEPRAZOLE SULPHONE;OMeprazole Related CoMpound A;5-Methoxy-2-(((4-Methoxy-3,5-diMethylpyridin-2-yl)Methyl)sulfonyl)-1H-benzo[d]iMidazole;H168/66;Amlodipine Impurity F;Esomeprazole USP RC A;EsoMeprazol iMpurity D;OMeprazole EP IMpurity D;EsoMeprazole iMpurity D;(OMEPRAZOLE SULFONE) (AS)
CBNumber
CB8505783
Molecular Formula
C17H19N3O4S
Formula Weight
361.42
MOL File
88546-55-8.mol
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OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS) Property

Melting point:
80-82°C
Boiling point:
599.3±60.0 °C(Predicted)
Density 
1.331±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,2-8°C
solubility 
≥40.6 mg/mL in DMSO,≥19.9 mg/mL in EtOH,insoluble in H2O
pka
7.97±0.10(Predicted)
BRN 
8347309
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
2
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
94319
Product name
Omeprazole sulfone
Purity
analytical standard
Packaging
5mg
Price
$408
Updated
2024/03/01
Sigma-Aldrich
Product number
1478516
Product name
Omeprazole Related Compound A
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
15mg
Price
$1380
Updated
2024/03/01
Cayman Chemical
Product number
18882
Product name
Omeprazole sulfone
Purity
≥98%
Packaging
5mg
Price
$86
Updated
2024/03/01
Cayman Chemical
Product number
18882
Product name
Omeprazole sulfone
Purity
≥98%
Packaging
10mg
Price
$161
Updated
2024/03/01
Sigma-Aldrich
Product number
PHR1648
Product name
Omeprazole Sulfone
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
30mg
Price
$711
Updated
2024/03/01
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OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS) Chemical Properties,Usage,Production

Description

Omeprazole sulfone is the major metabolite of the gastric proton pump inhibitor, omeprazole . It is produced by cytochrome P450 (CYP)3A4 sulfoxidation of esomeprazole and is found in plasma. Omeprazole sulfone has been shown to act as a reversible direct-acting and metabolism-dependent inhibitor of CYP2C19 in pooled human liver microsomes (IC50 = 18 μM).

Chemical Properties

Light Yellow Solid

Uses

A metabolite of Omeprazole.

Definition

ChEBI: Omeprazole sulfone is a sulfoxide and a member of benzimidazoles.

in vitro

omeprazole sulfone has been shown to act as a reversible direct-acting and metabolism-dependent inhibitor of cyp2c19 in pooled human liver microsomes with an ic50 of 18 μm [1].

in vivo

three hours after intake of 20 mg omeprazole only, the geometric mean plasma concentration of omeprazole sulfone were 106 nmol/l in 22 samples from subjects known to be extensive cyp2c19 metabolizers (em) and 672 nmol/l in the five subjects known to be poor cyp2c19 metabolizers (pm). the mean log10(omeprazole/omeprazole sulfone) ratio was 0.18 [4].

References

[1] nebert d w, russell d w. clinical importance of the cytochromes p450[j]. the lancet, 2002, 360(9340): 1155-1162.
[2] bel a, andersson t b, antonsson m, et al. stereoselective metabolism of omeprazole by human cytochrome p450 enzymes[j]. drug metabolism and disposition, 2000, 28(8): 966-972.
[3] nebert d w, russell d w. clinical importance of the cytochromes p450[j]. the lancet, 2002, 360(9340): 1155-1162.
[4] bttiger y. use of omeprazole sulfone in a single plasma sample as a probe for cyp3a4[j]. european journal of clinical pharmacology, 2006, 62(8): 621-625.

OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS) Preparation Products And Raw materials

Raw materials

Preparation Products

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OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS) Suppliers

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View Lastest Price from OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS) manufacturers

ShenZhen H&D Pharmaceutical Technology Co., LTD
Product
Omeprazole Impurity D 88546-55-8
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
0.98
Supply Ability
10g
Release date
2024-05-17
Career Henan Chemical Co
Product
OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS) 88546-55-8
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1000KG
Release date
2018-08-08

88546-55-8, OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS)Related Search:

5-METHOXY-2-[(3,5-DIMETHYL-2-PYRIDINYL)-METHYLSULFINYL]-BENZIMIDAZOLE 8-Methoxy-1,3-dimethyl-12-thioxo-pyrido[123,4]imidazo[1,2-a]benzimidazol-2- (12H)-one 5-METHOXY-2-[((4-METHOXY-3,5-DIMETHYL-1-OXIDO-2-PYRIDINYL)METHYL)SULFINYL]-BENZIMIDAZOLE 4-Hydroxy Omeprazole Sulfide 2-[[(3,5-DiMethyl-2-pyridinyl)Methyl]thio]-6-Methoxy-1H-benziMidazole Ufiprazole (S)-4-Desmethoxy-4-chloro Omeprazole Omeprazole Ondansetron EP Impurity H ammonium 1-(5-methoxy-1H-benzo[d]imidazol-2-yl)-3,5-dimethyl-4-oxo-1,4-dihydropyridine-2-carboxylate 4-Hydroxy Omeprazole omeprazole acid 2-[(5-CARBOXY-4-METHOXY-3-METHYLPYRID-2-YL)-METHYLSULFO]-5-METHOXYBENZIMIDAZOLE 2-MERCAPTO-5-METHOXYBENZIMIDAZOLE Omeprazole EP Impurity G Omeprazole Sulfone N-Oxide OMEPRAZOLE IMP. C (EP): 5-METHOXY-2-[[(4-METHOXY-3,5-DIMETHYLPYRIDIN-2-YL)METHYL]SULPHANYL]-1H-BENZIMIDAZOLE (UFIPRAZOLE) MM STANDARD Omeprazole Impurity (2-[[(5-hydroxy-1H-benzimidazol-2-yl)sulfinyl]methyl]-3,5-dimethy-l-4(1H)-pyridone) Omeprazole Related Compound A

  • Esomeprazole sodium D(H168/66)
  • Esomeprazole Sodium?CP Impurity Ⅰ
  • 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]sulfonyl]benzimidazole
  • EsoMeprazol iMpurity D
  • OMeprazole IMpurity-D(EP) (USP R C A)
  • 6-Methoxy-2-((4-Methoxy-3,5-diMethylpyridin-2-yl)Methylsulfonyl)-1H-benzo[d]iMidazole
  • OMeprazole EP IMpurity D
  • 5-Methoxy-2-[[(4-Methxoy-3,5-diMethylpyridin-2-yl)Methyl]sulfonyl]-1H-benziMidazole
  • 5-Methoxy-2-((4-Methoxy-3,5-diMethylpyridin-2-yl)Methylsulfonyl)-1H-benzo[d]iMidazole (RelCpd D)
  • 1H-BenziMidazole, 6-Methoxy -2-[[(4-Methoxy-3,5-diMethyl-2-pyridinyl)Methyl]sulfonyl]-
  • OMeprazole Related CoMpound A
  • EsoMeprazole iMpurity D
  • 5-Methoxy-2-(((4-Methoxy-3,5-diMethylpyridin-2-yl)Methyl)sulfonyl)-1H-benzo[d]iMidazole
  • Esomeprazole Magnesium Trihydrate Imp. D (EP): 5-Methoxy-2-[[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulphonyl]-1H-benzimidazole (Omeprazole Sulphone)
  • Amlodipine Impurity F
  • Omeprazole metabolite Omeprazole sulfone
  • Omeprazole Related Compound A (15 mg) (5-methoxy-2-[[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfonyl]-1H-benzimidazole)
  • Esomeprazole EP Impurity D
  • Esomeprazole Impurity D H168/66
  • Esomeprazole Magnesium Trihydrate EP D
  • USP Omeprazole Related Compound A
  • Omeprazole Sulfone USP Omeprazole Related Compound A
  • Omeprazole EP Impurity D (Omeprazole Sulfone)
  • Esomeprazole EP Impurity D(Omeprazole EP Impurity D)
  • Esomeprazole impurity 1/Esomeprazole EP Impurity D/Omeprazole EP Impurity D/Omeprazole Sulfone/5-Methoxy-2-[[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulphonyl]-1H-benzimidazole
  • Omeprazole impurity 4/Omeprazole EP Impurity D/Omeprazole Sulfone/5-Methoxy-2-[[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulphonyl]-1H-benzimidazole
  • OMEPRAZOLE RELATED COMPOUND A (15 MG) (OMEPRAZOLE SULFONE) (AS)
  • OMEPRAZOLE IMP. A (EP):5-METHOXY-1H-BENZIMIDAZOLE-2-THIOL MM STANDARD
  • 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfonyl]-1H-benzimidazole
  • 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfonyl]- 1H-benzimidazol
  • OMEPRAZOLE SULPHONE
  • 6-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfonyl]-1H-benzimidazole
  • OMeprazole Related CoMpound A (AS)
  • 6-Methoxy-2-{[(4-Methoxy-3,5-diMethylpyridin-2-yl)Methyl]sulfonyl}-1H-benziMidazole
  • Omeprazole Related Compound A (15 mg) (Omeprazole Sulfone or 5-methoxy-2-[[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulphonyl]-1H-benzimidazole)
  • (OMEPRAZOLE SULFONE) (AS)
  • EsoMeprazole related substance D
  • H168/66
  • 5-Methoxy-2-[[(4-Methxoy-3,5-diMethylpyridin-2-yl)Methyl]sulfonyl]-1H-benziMidazole(oMeprazole-sulfone)
  • -Methoxy-2-[[(4-Methxoy-3,5-diMethylpyridin-2-yl)Methyl]sulfonyl]-1H-benziMidazole(oMeprazole-sulfone)
  • IMp. D (EP): 5-Methoxy-2-[[(4-Methoxy-3,5-diMethylpyridin-2-yl)Methyl]sulphonyl]-1H- benziMidazole (OMeprazole Sulphone)
  • Omeprazole EP Impurity D：Omeprazole Impurity D
  • Omeprazole impurity D CRS
  • Omeprazole EP Impurity D (Esomeprazole Impurity D)
  • Omeprazole Related Compound A (15 mg)
  • Omeprazole EP Impurity D (Omeprazole Sulfone/ Esomeprazole EP Impurity D/ Esomeprazole Related Compound A)
  • Esomeprazole EP Impurity D/ Esomeprazole Related Compound A (Omeprazole EP Impurity D/ Omeprazole Sulfone)
  • Omeprazole Impurity D(Sulfoxide)
  • omeprazole Imp-D (sulfoxide)
  • Esomeprazole EP Impurity D/Esomeprazole RC A/Omeprazole EP Impurity D /Omeprazole Sulfone
  • 6-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sul...
  • Esomeprazole Impurities544
  • Esomeprazole EP Impuritie D
  • Omeprazole impurity DQ: What is Omeprazole impurity D Q: What is the CAS Number of Omeprazole impurity D Q: What is the storage condition of Omeprazole impurity D Q: What are the applications of Omeprazole impurity D
  • Omeprazole Related Compound A (5-methoxy-2-[[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfonyl]-1 (1478516)
  • Omeprazole Impurity D（EP)
  • Esomeprazole Magnesium Trihydrate Impurity D
  • Esomeprazole Sodium EP Impurity D