N-(DIPHENYLMETHYLENE)GLYCINE METHYL ESTER

Product Name: N-(DIPHENYLMETHYLENE)GLYCINE METHYL ESTER
CAS No.: 81167-39-7
Chemical Name: N-(DIPHENYLMETHYLENE)GLYCINE METHYL ESTER
Synonyms: DPM-Gly-OMe;LIXC-011 Cell;Methyl 3-aza-4,4-diphenylbut-3-enoat;Methyl N-(diphenylmethylene)glycinate;Methyl 3-aza-4,4-diphenylbut-3-enoate;Benzophenoneimine glycine Methyl Ester;methyl 2-(benzhydrylideneamino)acetate;methyl2-(diphenylmethyleneamino)acetate;Diphenylmethylene-Glycine Methyl ester;N-(DIPHENYLMETHYLENE)GLYCINE METHYL ESTER
CBNumber: CB8506715
Molecular Formula: C16H15NO2
Formula Weight: 253.3
MOL File: 81167-39-7.mol

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N-(DIPHENYLMETHYLENE)GLYCINE METHYL ESTER Property

Melting point:: 42-44?C
Boiling point:: 342.8±34.0 °C(Predicted)
Density: 1.05±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
pka: 2.22±0.50(Predicted)
form: Solid
color: White to pale yellow
InChI: InChI=1S/C16H15NO2/c1-19-15(18)12-17-16(13-8-4-2-5-9-13)14-10-6-3-7-11-14/h2-11H,12H2,1H3
InChIKey: PQTOLHHWLUCKSB-UHFFFAOYSA-N
SMILES: C(OC)(=O)C/N=C(/C1=CC=CC=C1)\C1=CC=CC=C1

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Safety

HS Code: 2925199590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: D3141
Product name: Methyl 2-[(Diphenylmethylene)amino]acetate
Packaging: 25G
Price: $87
Updated: 2025/07/31

TRC

Product number: D491805
Product name: N-(Diphenylmethylene)glycineMethylEster
Packaging: 1g
Price: $85
Updated: 2021/12/16

AK Scientific

Product number: J90705
Product name: MethylN-(diphenylmethylene)glycinate
Packaging: 5g
Price: $15
Updated: 2021/12/16

Matrix Scientific

Product number: 075588
Product name: Methyl N-(diphenylmethylene)glycinate
Purity: 95+%
Packaging: 25g
Price: $38
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD22505
Product name: N-(Diphenylmethylene)glycine methyl ester
Packaging: 25g
Price: $100
Updated: 2021/12/16

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N-(DIPHENYLMETHYLENE)GLYCINE METHYL ESTER Chemical Properties,Usage,Production

Chemical Properties

Off-White to Pale Yellow Solid

Uses

N-(Diphenylmethylene)glycine Methyl Ester (cas# 81167-39-7) is a compound useful in organic synthesis.

Synthesis Reference(s)

Tetrahedron Letters, 23, p. 2863, 1982 DOI: 10.1016/S0040-4039(00)88434-8

Synthesis

1013-88-3

5680-79-5

81167-39-7

Benzophenone imine (25.00 g, 137 mmol) was added in a single addition to a stirring solution of glycine methyl ester hydrochloride (17.49 g, 139 mmol) in anhydrous dichloromethane (150 mL) under nitrogen atmosphere and at room temperature. The reaction mixture was stirred continuously for 24 h, during which ammonium chloride precipitation was observed to be generated. Upon completion of the reaction, water (20 mL) was added for layering. The organic layer was washed sequentially with saturated sodium carbonate solution (2 x 20 mL) and brine (20 mL). The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated using a rotary evaporator to give about 35 g of a thick light brown slurry (99% purity) in near 100% yield. The product did not require further purification and could be used directly in the subsequent reaction.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 15, p. 1975 - 1979
[2] Patent: WO2004/5293, 2004, A2. Location in patent: Page 69-70
[3] Patent: WO2006/23630, 2006, A2. Location in patent: Page/Page column 39-40; 65
[4] Chemistry - A European Journal, 2012, vol. 18, # 12, p. 3773 - 3779
[5] Organic Process Research and Development, 2018, vol. 22, # 10, p. 1458 - 1460

N-(DIPHENYLMETHYLENE)GLYCINE METHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(DIPHENYLMETHYLENE)GLYCINE METHYL ESTER Suppliers

Canada 1 China 129 India 4 United Kingdom 2 United States 12 Global 148

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View Lastest Price from N-(DIPHENYLMETHYLENE)GLYCINE METHYL ESTER manufacturers

Career Henan Chemical Co

Product: N-(DIPHENYLMETHYLENE)GLYCINE METHYL ESTER 81167-39-7
Price: US $100.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Customized
Release date: 2018-07-26

81167-39-7, N-(DIPHENYLMETHYLENE)GLYCINE METHYL ESTERRelated Search:

Furosemide 2-(7-Methoxynaphthalen-1-yl)acetic acid 2-bromo-3,5-dichlorobenzenamine 1,3-Dimethoxy-2-propanol Dimethyl acetylsuccinate Ethyl N-(diphenylmethylene)glycinate ETHYL LOFLAZEPATE N-(Diphenylmethylene)glycerine tert-butyl ester N-(DIPHENYLMETHYLENE)-GLYCINE, PHENYLMETHYL ESTER N-(DIPHENYLMETHYLENE)GLYCINE METHYL ESTER N-DIPHENYLMETHYLENE-O-(2,3,6,2',3',4',6'-HEPTA-O-ACETYL-BETA-D-LACTOSYL)-L-SERINE, BENZYL ESTER (R)-METHYL 2-(DIPHENYLMETHYLENEAMINO)-3-HYDROXYPROPANOATE (S)-METHYL 2-(DIPHENYLMETHYLENEAMINO)-3-HYDROXYPROPANOATE BENZYL N-(DIPHENYLMETHYLENE)-L-SERINATE BP-(2R, 2S)-GLY(2-OAC)-OME Ethyl AURORA KA-6709 AURORA KA-6708

Methyl 2-[(diphenylmethylidene)amino]acetate

Glycine, N-(diphenylmethylene)-, methyl ester

methyl 2-(benzhydrylideneamino)acetate

DPM-Gly-OMe

(N,N-diphenylmethylgene)glycine methyl ester

(Benzhydrylideneamino)acetic Acid Methyl Ester

Benzophenoneimine glycine Methyl Ester

Methyl 3-aza-4,4-diphenylbut-3-enoat

Methyl 3-aza-4,4-diphenylbut-3-enoate

Methyl N-(diphenylmethylene)glycinate

Diphenylmethylene-Glycine Methyl ester

N-(DIPHENYLMETHYLENE)GLYCINE METHYL ESTER

methyl2-(diphenylmethyleneamino)acetate

DPM-Gly-OMe DiphenylMethylene-Glycine Methyl ester

N-(DIPHENYLMETHYLENE)GLYCINE METHYL ESTER USP/EP/BP

LIXC-011 Cell

81167-39-7

Amino Acids 13C, 2H, 15N

Amino Acids & Derivatives