ChemicalBook > CAS DataBase List > N-(DIPHENYLMETHYLENE)GLYCINE METHYL ESTER

N-(DIPHENYLMETHYLENE)GLYCINE METHYL ESTER

Product Name
N-(DIPHENYLMETHYLENE)GLYCINE METHYL ESTER
CAS No.
81167-39-7
Chemical Name
N-(DIPHENYLMETHYLENE)GLYCINE METHYL ESTER
Synonyms
DPM-Gly-OMe;LIXC-011 Cell;Methyl 3-aza-4,4-diphenylbut-3-enoat;Methyl N-(diphenylmethylene)glycinate;Methyl 3-aza-4,4-diphenylbut-3-enoate;Benzophenoneimine glycine Methyl Ester;methyl 2-(benzhydrylideneamino)acetate;methyl2-(diphenylmethyleneamino)acetate;Diphenylmethylene-Glycine Methyl ester;N-(DIPHENYLMETHYLENE)GLYCINE METHYL ESTER
CBNumber
CB8506715
Molecular Formula
C16H15NO2
Formula Weight
253.3
MOL File
81167-39-7.mol
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N-(DIPHENYLMETHYLENE)GLYCINE METHYL ESTER Property

Melting point:
42-44?C
Boiling point:
342.8±34.0 °C(Predicted)
Density 
1.05±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,2-8°C
pka
2.22±0.50(Predicted)
form 
Solid
color 
White to pale yellow
InChI
InChI=1S/C16H15NO2/c1-19-15(18)12-17-16(13-8-4-2-5-9-13)14-10-6-3-7-11-14/h2-11H,12H2,1H3
InChIKey
PQTOLHHWLUCKSB-UHFFFAOYSA-N
SMILES
C(OC)(=O)C/N=C(/C1=CC=CC=C1)\C1=CC=CC=C1
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Safety

HS Code 
2925199590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
D3141
Product name
Methyl 2-[(Diphenylmethylene)amino]acetate
Packaging
25G
Price
$87
Updated
2025/07/31
TRC
Product number
D491805
Product name
N-(Diphenylmethylene)glycineMethylEster
Packaging
1g
Price
$85
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD22505
Product name
N-(Diphenylmethylene)glycine methyl ester
Packaging
25g
Price
$100
Updated
2021/12/16
AK Scientific
Product number
J90705
Product name
MethylN-(diphenylmethylene)glycinate
Packaging
5g
Price
$15
Updated
2021/12/16
Matrix Scientific
Product number
075588
Product name
Methyl N-(diphenylmethylene)glycinate
Purity
95+%
Packaging
25g
Price
$38
Updated
2021/12/16
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N-(DIPHENYLMETHYLENE)GLYCINE METHYL ESTER Chemical Properties,Usage,Production

Chemical Properties

Off-White to Pale Yellow Solid

Uses

N-(Diphenylmethylene)glycine Methyl Ester (cas# 81167-39-7) is a compound useful in organic synthesis.

Synthesis Reference(s)

Tetrahedron Letters, 23, p. 2863, 1982 DOI: 10.1016/S0040-4039(00)88434-8

Synthesis

1013-88-3

5680-79-5

81167-39-7

Benzophenone imine (25.00 g, 137 mmol) was added in a single addition to a stirring solution of glycine methyl ester hydrochloride (17.49 g, 139 mmol) in anhydrous dichloromethane (150 mL) under nitrogen atmosphere and at room temperature. The reaction mixture was stirred continuously for 24 h, during which ammonium chloride precipitation was observed to be generated. Upon completion of the reaction, water (20 mL) was added for layering. The organic layer was washed sequentially with saturated sodium carbonate solution (2 x 20 mL) and brine (20 mL). The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated using a rotary evaporator to give about 35 g of a thick light brown slurry (99% purity) in near 100% yield. The product did not require further purification and could be used directly in the subsequent reaction.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 15, p. 1975 - 1979
[2] Patent: WO2004/5293, 2004, A2. Location in patent: Page 69-70
[3] Patent: WO2006/23630, 2006, A2. Location in patent: Page/Page column 39-40; 65
[4] Chemistry - A European Journal, 2012, vol. 18, # 12, p. 3773 - 3779
[5] Organic Process Research and Development, 2018, vol. 22, # 10, p. 1458 - 1460

N-(DIPHENYLMETHYLENE)GLYCINE METHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from N-(DIPHENYLMETHYLENE)GLYCINE METHYL ESTER manufacturers

Career Henan Chemical Co
Product
N-(DIPHENYLMETHYLENE)GLYCINE METHYL ESTER 81167-39-7
Price
US $100.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
Customized
Release date
2018-07-26

81167-39-7, N-(DIPHENYLMETHYLENE)GLYCINE METHYL ESTERRelated Search:

Furosemide 2-(7-Methoxynaphthalen-1-yl)acetic acid 2-bromo-3,5-dichlorobenzenamine 1,3-Dimethoxy-2-propanol Dimethyl acetylsuccinate Ethyl N-(diphenylmethylene)glycinate ETHYL LOFLAZEPATE N-(Diphenylmethylene)glycerine tert-butyl ester N-(DIPHENYLMETHYLENE)-GLYCINE, PHENYLMETHYL ESTER N-(DIPHENYLMETHYLENE)GLYCINE METHYL ESTER N-DIPHENYLMETHYLENE-O-(2,3,6,2',3',4',6'-HEPTA-O-ACETYL-BETA-D-LACTOSYL)-L-SERINE, BENZYL ESTER (R)-METHYL 2-(DIPHENYLMETHYLENEAMINO)-3-HYDROXYPROPANOATE (S)-METHYL 2-(DIPHENYLMETHYLENEAMINO)-3-HYDROXYPROPANOATE BENZYL N-(DIPHENYLMETHYLENE)-L-SERINATE BP-(2R, 2S)-GLY(2-OAC)-OME Ethyl AURORA KA-6709 AURORA KA-6708

  • Methyl 2-[(diphenylmethylidene)amino]acetate
  • Glycine, N-(diphenylmethylene)-, methyl ester
  • methyl 2-(benzhydrylideneamino)acetate
  • DPM-Gly-OMe
  • (N,N-diphenylmethylgene)glycine methyl ester
  • (Benzhydrylideneamino)acetic Acid Methyl Ester
  • Benzophenoneimine glycine Methyl Ester
  • Methyl 3-aza-4,4-diphenylbut-3-enoat
  • Methyl 3-aza-4,4-diphenylbut-3-enoate
  • Methyl N-(diphenylmethylene)glycinate
  • Diphenylmethylene-Glycine Methyl ester
  • N-(DIPHENYLMETHYLENE)GLYCINE METHYL ESTER
  • methyl2-(diphenylmethyleneamino)acetate
  • DPM-Gly-OMe DiphenylMethylene-Glycine Methyl ester
  • N-(DIPHENYLMETHYLENE)GLYCINE METHYL ESTER USP/EP/BP
  • LIXC-011 Cell
  • 81167-39-7
  • Amino Acids 13C, 2H, 15N
  • Amino Acids & Derivatives